TP8L1_HUMAN
ID TP8L1_HUMAN Reviewed; 186 AA.
AC Q8WVP5; D6W627;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Tumor necrosis factor alpha-induced protein 8-like protein 1;
DE Short=TIPE1 {ECO:0000250|UniProtKB:Q8K288};
DE Short=TNF alpha-induced protein 8-like protein 1;
DE Short=TNFAIP8-like protein 1;
DE AltName: Full=Oxidative stress-regulated gene-beta {ECO:0000303|PubMed:24444419};
DE Short=Oxy-beta {ECO:0000303|PubMed:24444419};
GN Name=TNFAIP8L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-118.
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=21600655; DOI=10.1016/j.molimm.2011.04.023;
RA Cui J., Zhang G., Hao C., Wang Y., Lou Y., Zhang W., Wang J., Liu S.;
RT "The expression of TIPE1 in murine tissues and human cell lines.";
RL Mol. Immunol. 48:1548-1555(2011).
RN [5]
RP INDUCTION.
RX PubMed=24444419; DOI=10.1111/jnc.12643;
RA Ha J.Y., Kim J.S., Kang Y.H., Bok E., Kim Y.S., Son J.H.;
RT "Tnfaip8 l1/Oxi-beta binds to FBXW5, increasing autophagy through
RT activation of TSC2 in a Parkinson's disease model.";
RL J. Neurochem. 129:527-538(2014).
CC -!- FUNCTION: Acts as a negative regulator of mTOR activity.
CC {ECO:0000250|UniProtKB:Q8K288}.
CC -!- SUBUNIT: Interacts with FBXW5; TNFAIP8L1 competes with TSC2 to bind
CC FBXW5 increasing TSC2 stability by preventing its ubiquitination.
CC {ECO:0000250|UniProtKB:Q8K288}.
CC -!- INTERACTION:
CC Q8WVP5; Q8N2N9-4: ANKRD36B; NbExp=5; IntAct=EBI-752102, EBI-12170453;
CC Q8WVP5; Q6NZI2: CAVIN1; NbExp=3; IntAct=EBI-752102, EBI-2559016;
CC Q8WVP5; Q92997: DVL3; NbExp=6; IntAct=EBI-752102, EBI-739789;
CC Q8WVP5; O60447: EVI5; NbExp=3; IntAct=EBI-752102, EBI-852291;
CC Q8WVP5; Q92876: KLK6; NbExp=3; IntAct=EBI-752102, EBI-2432309;
CC Q8WVP5; Q9NPJ6: MED4; NbExp=3; IntAct=EBI-752102, EBI-394607;
CC Q8WVP5; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-752102, EBI-742388;
CC Q8WVP5; P61289: PSME3; NbExp=6; IntAct=EBI-752102, EBI-355546;
CC Q8WVP5; P32969: RPL9P9; NbExp=3; IntAct=EBI-752102, EBI-358122;
CC Q8WVP5; P09012: SNRPA; NbExp=3; IntAct=EBI-752102, EBI-607085;
CC Q8WVP5; Q96MF2: STAC3; NbExp=3; IntAct=EBI-752102, EBI-745680;
CC Q8WVP5; Q8WVP5: TNFAIP8L1; NbExp=3; IntAct=EBI-752102, EBI-752102;
CC Q8WVP5; Q15696: ZRSR2; NbExp=3; IntAct=EBI-752102, EBI-6657923;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8K288}.
CC -!- TISSUE SPECIFICITY: High expression detected in most carcinoma cell
CC lines, especially in cells transformed with virus genomes.
CC {ECO:0000269|PubMed:21600655}.
CC -!- INDUCTION: Up-regulated by oxidative stress (OS) at both
CC transcriptional and translational levels.
CC {ECO:0000269|PubMed:24444419}.
CC -!- SIMILARITY: Belongs to the TNFAIP8 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC005339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471139; EAW69204.1; -; Genomic_DNA.
DR EMBL; CH471139; EAW69205.1; -; Genomic_DNA.
DR EMBL; BC017672; AAH17672.1; -; mRNA.
DR CCDS; CCDS12132.1; -.
DR RefSeq; NP_001161414.1; NM_001167942.1.
DR RefSeq; NP_689575.2; NM_152362.2.
DR RefSeq; XP_005259544.1; XM_005259487.3.
DR RefSeq; XP_011525982.1; XM_011527680.2.
DR AlphaFoldDB; Q8WVP5; -.
DR SMR; Q8WVP5; -.
DR BioGRID; 125973; 18.
DR IntAct; Q8WVP5; 12.
DR STRING; 9606.ENSP00000444215; -.
DR iPTMnet; Q8WVP5; -.
DR PhosphoSitePlus; Q8WVP5; -.
DR BioMuta; TNFAIP8L1; -.
DR DMDM; 146325794; -.
DR EPD; Q8WVP5; -.
DR MassIVE; Q8WVP5; -.
DR PaxDb; Q8WVP5; -.
DR PeptideAtlas; Q8WVP5; -.
DR PRIDE; Q8WVP5; -.
DR ProteomicsDB; 74809; -.
DR Antibodypedia; 23694; 53 antibodies from 21 providers.
DR DNASU; 126282; -.
DR Ensembl; ENST00000327473.9; ENSP00000331827.3; ENSG00000185361.9.
DR Ensembl; ENST00000536716.1; ENSP00000444215.1; ENSG00000185361.9.
DR GeneID; 126282; -.
DR KEGG; hsa:126282; -.
DR MANE-Select; ENST00000327473.9; ENSP00000331827.3; NM_152362.3; NP_689575.2.
DR UCSC; uc002max.4; human.
DR CTD; 126282; -.
DR DisGeNET; 126282; -.
DR GeneCards; TNFAIP8L1; -.
DR HGNC; HGNC:28279; TNFAIP8L1.
DR HPA; ENSG00000185361; Tissue enhanced (liver).
DR MIM; 615869; gene.
DR neXtProt; NX_Q8WVP5; -.
DR OpenTargets; ENSG00000185361; -.
DR PharmGKB; PA142670722; -.
DR VEuPathDB; HostDB:ENSG00000185361; -.
DR eggNOG; ENOG502S00N; Eukaryota.
DR GeneTree; ENSGT00390000003488; -.
DR HOGENOM; CLU_085918_1_0_1; -.
DR InParanoid; Q8WVP5; -.
DR OMA; HQAVNTH; -.
DR OrthoDB; 1284744at2759; -.
DR PhylomeDB; Q8WVP5; -.
DR TreeFam; TF323415; -.
DR PathwayCommons; Q8WVP5; -.
DR Reactome; R-HSA-1483255; PI Metabolism.
DR SignaLink; Q8WVP5; -.
DR BioGRID-ORCS; 126282; 16 hits in 1076 CRISPR screens.
DR ChiTaRS; TNFAIP8L1; human.
DR GenomeRNAi; 126282; -.
DR Pharos; Q8WVP5; Tdark.
DR PRO; PR:Q8WVP5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8WVP5; protein.
DR Bgee; ENSG00000185361; Expressed in bronchial epithelial cell and 147 other tissues.
DR Genevisible; Q8WVP5; HS.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0032007; P:negative regulation of TOR signaling; ISS:UniProtKB.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR Gene3D; 1.20.1440.160; -; 1.
DR InterPro; IPR008477; TNFAIP8-like.
DR InterPro; IPR038355; TNFAIP8_sf.
DR PANTHER; PTHR12757; PTHR12757; 1.
DR Pfam; PF05527; DUF758; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..186
FT /note="Tumor necrosis factor alpha-induced protein 8-like
FT protein 1"
FT /id="PRO_0000285724"
FT VARIANT 118
FT /note="A -> V (in dbSNP:rs17851549)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_032048"
SQ SEQUENCE 186 AA; 20827 MW; 352B0E7A2FB6D216 CRC64;
MDTFSTKSLA LQAQKKLLSK MASKAVVAVL VDDTSSEVLD ELYRATREFT RSRKEAQKML
KNLVKVALKL GLLLRGDQLG GEELALLRRF RHRARCLAMT AVSFHQVDFT FDRRVLAAGL
LECRDLLHQA VGPHLTAKSH GRINHVFGHL ADCDFLAALY GPAEPYRSHL RRICEGLGRM
LDEGSL
