TP8L1_MOUSE
ID TP8L1_MOUSE Reviewed; 186 AA.
AC Q8K288; Q3U6E5; Q9D0N6; Q9DBH7;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Tumor necrosis factor alpha-induced protein 8-like protein 1;
DE Short=TIPE1 {ECO:0000303|PubMed:21600655};
DE Short=TNF alpha-induced protein 8-like protein 1;
DE Short=TNFAIP8-like protein 1;
DE AltName: Full=Oxidative stress regulated gene-beta {ECO:0000303|PubMed:19878437};
DE Short=Oxy-beta {ECO:0000303|PubMed:19878437};
GN Name=Tnfaip8l1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, Liver, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP INDUCTION.
RX PubMed=19878437; DOI=10.1111/j.1471-4159.2009.06463.x;
RA Choi K.C., Kim S.H., Ha J.Y., Kim S.T., Son J.H.;
RT "A novel mTOR activating protein protects dopamine neurons against
RT oxidative stress by repressing autophagy related cell death.";
RL J. Neurochem. 112:366-376(2010).
RN [5]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=21600655; DOI=10.1016/j.molimm.2011.04.023;
RA Cui J., Zhang G., Hao C., Wang Y., Lou Y., Zhang W., Wang J., Liu S.;
RT "The expression of TIPE1 in murine tissues and human cell lines.";
RL Mol. Immunol. 48:1548-1555(2011).
RN [6]
RP FUNCTION, INTERACTION WITH FBXW5, AND INDUCTION.
RX PubMed=24444419; DOI=10.1111/jnc.12643;
RA Ha J.Y., Kim J.S., Kang Y.H., Bok E., Kim Y.S., Son J.H.;
RT "Tnfaip8 l1/Oxi-beta binds to FBXW5, increasing autophagy through
RT activation of TSC2 in a Parkinson's disease model.";
RL J. Neurochem. 129:527-538(2014).
CC -!- FUNCTION: Acts as a negative regulator of mTOR activity.
CC {ECO:0000269|PubMed:24444419}.
CC -!- SUBUNIT: Interacts with FBXW5; TNFAIP8L1 competes with TSC2 to bind
CC FBXW5 increasing TSC2 stability by preventing its ubiquitination.
CC {ECO:0000269|PubMed:24444419}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21600655}.
CC -!- TISSUE SPECIFICITY: Detected in wide variety tissues, such as neurons
CC in brain, hepatocytes, germ cells of female and male reproductive
CC organs, muscular tissues and variety types of cells of the epithelial
CC origin (at protein level). {ECO:0000269|PubMed:21600655}.
CC -!- INDUCTION: Up-regulated by oxidative stress and by 6-hydroxydopamine
CC (6-OHDA) in dopaminergic neurons. {ECO:0000269|PubMed:19878437,
CC ECO:0000269|PubMed:24444419}.
CC -!- SIMILARITY: Belongs to the TNFAIP8 family. {ECO:0000305}.
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DR EMBL; AK004949; BAB23693.1; -; mRNA.
DR EMBL; AK011245; BAB27492.1; -; mRNA.
DR EMBL; AK090348; BAC41180.1; -; mRNA.
DR EMBL; AK136962; BAE23189.1; -; mRNA.
DR EMBL; AK150678; BAE29758.1; -; mRNA.
DR EMBL; AK153177; BAE31780.1; -; mRNA.
DR EMBL; BC032199; AAH32199.1; -; mRNA.
DR CCDS; CCDS28897.1; -.
DR RefSeq; NP_079842.2; NM_025566.3.
DR AlphaFoldDB; Q8K288; -.
DR SMR; Q8K288; -.
DR STRING; 10090.ENSMUSP00000076961; -.
DR PhosphoSitePlus; Q8K288; -.
DR EPD; Q8K288; -.
DR MaxQB; Q8K288; -.
DR PaxDb; Q8K288; -.
DR PeptideAtlas; Q8K288; -.
DR PRIDE; Q8K288; -.
DR ProteomicsDB; 258818; -.
DR Antibodypedia; 23694; 53 antibodies from 21 providers.
DR DNASU; 66443; -.
DR Ensembl; ENSMUST00000077788; ENSMUSP00000076961; ENSMUSG00000044469.
DR GeneID; 66443; -.
DR KEGG; mmu:66443; -.
DR UCSC; uc008dbf.2; mouse.
DR CTD; 126282; -.
DR MGI; MGI:1913693; Tnfaip8l1.
DR VEuPathDB; HostDB:ENSMUSG00000044469; -.
DR eggNOG; ENOG502S00N; Eukaryota.
DR GeneTree; ENSGT00390000003488; -.
DR HOGENOM; CLU_085918_1_0_1; -.
DR InParanoid; Q8K288; -.
DR OMA; HQAVNTH; -.
DR OrthoDB; 1284744at2759; -.
DR PhylomeDB; Q8K288; -.
DR TreeFam; TF323415; -.
DR Reactome; R-MMU-1483255; PI Metabolism.
DR BioGRID-ORCS; 66443; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Tnfaip8l1; mouse.
DR PRO; PR:Q8K288; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8K288; protein.
DR Bgee; ENSMUSG00000044469; Expressed in left lobe of liver and 175 other tissues.
DR Genevisible; Q8K288; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IDA:UniProtKB.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR Gene3D; 1.20.1440.160; -; 1.
DR InterPro; IPR008477; TNFAIP8-like.
DR InterPro; IPR038355; TNFAIP8_sf.
DR PANTHER; PTHR12757; PTHR12757; 1.
DR Pfam; PF05527; DUF758; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..186
FT /note="Tumor necrosis factor alpha-induced protein 8-like
FT protein 1"
FT /id="PRO_0000285725"
FT CONFLICT 52
FT /note="S -> T (in Ref. 1; BAB27492/BAB23693)"
FT /evidence="ECO:0000305"
FT CONFLICT 96
FT /note="S -> N (in Ref. 1; BAB27492)"
FT /evidence="ECO:0000305"
FT CONFLICT 149
FT /note="H -> N (in Ref. 1; BAE31780)"
FT /evidence="ECO:0000305"
FT CONFLICT 156
FT /note="L -> M (in Ref. 1; BAE31780)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 186 AA; 20818 MW; 25561E78CAC0AB63 CRC64;
MDTFSTKSLA LQAQKKVLSK MASKAMVAVF VDNTSSEVLD ELYQATKEFT RSRKEAQRVV
KNLVKVAVKL AVLLRADQLD SNELAQLQRF RGRVRSLAMT ALSFHQVDFT FDRRVLATGL
LECRDLLHQA IGPHLTAKSH GRINHIFSHF ANGDFLAALY SPAEPYRSHL CRICDGLGRM
LDEGGI
