ID   TP8L2_BOVIN             Reviewed;         184 AA.
AC   Q3ZBK5;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Tumor necrosis factor alpha-induced protein 8-like protein 2;
DE            Short=TIPE2;
DE            Short=TNF alpha-induced protein 8-like protein 2;
DE            Short=TNFAIP8-like protein 2;
GN   Name=TNFAIP8L2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a negative regulator of innate and adaptive immunity
CC       by maintaining immune homeostasis. Negative regulator of Toll-like
CC       receptor and T-cell receptor function. Prevents hyperresponsiveness of
CC       the immune system and maintains immune homeostasis. Inhibits JUN/AP1
CC       and NF-kappa-B activation. Promotes Fas-induced apoptosis (By
CC       similarity). {ECO:0000250}.
CC   -!- DOMAIN: The central region was initially thought to constitute a DED
CC       (death effector) domain. However, 3D-structure data reveal a previously
CC       uncharacterized fold that is different from the predicted fold of a DED
CC       (death effector) domain. It consists of a large, hydrophobic central
CC       cavity that is poised for cofactor binding (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC103244; AAI03245.1; -; mRNA.
DR   RefSeq; NP_001029561.1; NM_001034389.1.
DR   AlphaFoldDB; Q3ZBK5; -.
DR   SMR; Q3ZBK5; -.
DR   STRING; 9913.ENSBTAP00000027182; -.
DR   PaxDb; Q3ZBK5; -.
DR   PRIDE; Q3ZBK5; -.
DR   Ensembl; ENSBTAT00000027182; ENSBTAP00000027182; ENSBTAG00000020394.
DR   GeneID; 510652; -.
DR   KEGG; bta:510652; -.
DR   CTD; 79626; -.
DR   VEuPathDB; HostDB:ENSBTAG00000020394; -.
DR   VGNC; VGNC:36159; TNFAIP8L2.
DR   eggNOG; ENOG502QST4; Eukaryota.
DR   GeneTree; ENSGT00390000003488; -.
DR   HOGENOM; CLU_085918_1_0_1; -.
DR   InParanoid; Q3ZBK5; -.
DR   OMA; IRRVFDH; -.
DR   OrthoDB; 1284744at2759; -.
DR   TreeFam; TF323415; -.
DR   Reactome; R-BTA-1483255; PI Metabolism.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000020394; Expressed in blood and 94 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; IBA:GO_Central.
DR   GO; GO:0050868; P:negative regulation of T cell activation; IBA:GO_Central.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   GO; GO:0042110; P:T cell activation; IEA:Ensembl.
DR   Gene3D; 1.20.1440.160; -; 1.
DR   InterPro; IPR008477; TNFAIP8-like.
DR   InterPro; IPR038355; TNFAIP8_sf.
DR   PANTHER; PTHR12757; PTHR12757; 1.
DR   Pfam; PF05527; DUF758; 1.
PE   2: Evidence at transcript level;
KW   Immunity; Innate immunity; Reference proteome.
FT   CHAIN           1..184
FT                   /note="Tumor necrosis factor alpha-induced protein 8-like
FT                   protein 2"
FT                   /id="PRO_0000285770"
SQ   SEQUENCE   184 AA;  20574 MW;  BE9DB4229D74A2CC CRC64;
     MESFSSKSLV LQAEKKLLSK MAGRSVAHLF ADETSSEVLD ELYRVSKEYT RSRPQAQRVI
     KDLIKVAVKV AVLHRSGCFN PSELALATRF RQKLRQGAMT ALSFGEVDFT FEAAVLASLL
     TECRDVLLEL VERHLTPKSH GRIRHVFDHF SDAGLLTALY GPDYTQHLGK ICGGLRKLLD
     EGKL