TP8L2_MOUSE
ID TP8L2_MOUSE Reviewed; 184 AA.
AC Q9D8Y7;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Tumor necrosis factor alpha-induced protein 8-like protein 2;
DE Short=TIPE2;
DE Short=TNF alpha-induced protein 8-like protein 2;
DE Short=TNFAIP8-like protein 2;
GN Name=Tnfaip8l2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CASP8, INDUCTION,
RP TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RC STRAIN=C57BL/6J; TISSUE=Spinal cord;
RX PubMed=18455983; DOI=10.1016/j.cell.2008.03.026;
RA Sun H., Gong S., Carmody R.J., Hilliard A., Li L., Sun J., Kong L., Xu L.,
RA Hilliard B., Hu S., Shen H., Yang X., Chen Y.H.;
RT "TIPE2, a negative regulator of innate and adaptive immunity that maintains
RT immune homeostasis.";
RL Cell 133:415-426(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary tumor, and Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Acts as a negative regulator of innate and adaptive immunity
CC by maintaining immune homeostasis. Negative regulator of Toll-like
CC receptor and T-cell receptor function. Prevents hyperresponsiveness of
CC the immune system and maintains immune homeostasis. Inhibits JUN/AP1
CC and NF-kappa-B activation. Promotes Fas-induced apoptosis.
CC {ECO:0000269|PubMed:18455983}.
CC -!- SUBUNIT: May interact with CASP8; however, such result is unclear.
CC -!- INTERACTION:
CC Q9D8Y7; O89110: Casp8; NbExp=2; IntAct=EBI-1781612, EBI-851690;
CC -!- TISSUE SPECIFICITY: Expressed in thymus, spleen, lymph node and small
CC intestine, but not in liver, heart, muscle, testis, spinal cord or
CC brain. Up-regulated in the spinal cord of mice with experimental
CC autoimmune encephalomyelitis. Constitutively expressed by macrophages,
CC B and T-lymphocytes at various developmental stages.
CC {ECO:0000269|PubMed:18455983}.
CC -!- INDUCTION: By TNF in fibroblasts. {ECO:0000269|PubMed:18455983}.
CC -!- DOMAIN: The central region was initially thought to constitute a DED
CC (death effector) domain. However, 3D-structure data reveal a previously
CC uncharacterized fold that is different from the predicted fold of a DED
CC (death effector) domain. It consists of a large, hydrophobic central
CC cavity that is poised for cofactor binding (By similarity).
CC {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: Multiorgan inflammation, splenomegaly and
CC premature death. Mice are hypersensitive to septic shock.
CC {ECO:0000269|PubMed:18455983}.
CC -!- SIMILARITY: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
CC {ECO:0000305}.
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DR EMBL; AF548004; AAQ12263.1; -; mRNA.
DR EMBL; AK007540; BAB25098.1; -; mRNA.
DR EMBL; BC055879; AAH55879.1; -; mRNA.
DR EMBL; BC094616; AAH94616.1; -; mRNA.
DR CCDS; CCDS17603.1; -.
DR RefSeq; NP_081482.1; NM_027206.2.
DR RefSeq; XP_006502103.1; XM_006502040.3.
DR AlphaFoldDB; Q9D8Y7; -.
DR SMR; Q9D8Y7; -.
DR BioGRID; 213666; 1.
DR IntAct; Q9D8Y7; 2.
DR STRING; 10090.ENSMUSP00000013851; -.
DR PhosphoSitePlus; Q9D8Y7; -.
DR EPD; Q9D8Y7; -.
DR MaxQB; Q9D8Y7; -.
DR PaxDb; Q9D8Y7; -.
DR PeptideAtlas; Q9D8Y7; -.
DR PRIDE; Q9D8Y7; -.
DR ProteomicsDB; 258960; -.
DR Antibodypedia; 34053; 160 antibodies from 26 providers.
DR DNASU; 69769; -.
DR Ensembl; ENSMUST00000013851; ENSMUSP00000013851; ENSMUSG00000013707.
DR GeneID; 69769; -.
DR KEGG; mmu:69769; -.
DR UCSC; uc008qif.1; mouse.
DR CTD; 79626; -.
DR MGI; MGI:1917019; Tnfaip8l2.
DR VEuPathDB; HostDB:ENSMUSG00000013707; -.
DR eggNOG; ENOG502QST4; Eukaryota.
DR GeneTree; ENSGT00390000003488; -.
DR HOGENOM; CLU_085918_1_0_1; -.
DR InParanoid; Q9D8Y7; -.
DR OMA; IRRVFDH; -.
DR OrthoDB; 1284744at2759; -.
DR PhylomeDB; Q9D8Y7; -.
DR TreeFam; TF323415; -.
DR Reactome; R-MMU-1483255; PI Metabolism.
DR BioGRID-ORCS; 69769; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q9D8Y7; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9D8Y7; protein.
DR Bgee; ENSMUSG00000013707; Expressed in granulocyte and 110 other tissues.
DR Genevisible; Q9D8Y7; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IMP:MGI.
DR GO; GO:0050868; P:negative regulation of T cell activation; IMP:MGI.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0042110; P:T cell activation; IMP:MGI.
DR Gene3D; 1.20.1440.160; -; 1.
DR InterPro; IPR008477; TNFAIP8-like.
DR InterPro; IPR038355; TNFAIP8_sf.
DR PANTHER; PTHR12757; PTHR12757; 1.
DR Pfam; PF05527; DUF758; 1.
PE 1: Evidence at protein level;
KW Immunity; Innate immunity; Reference proteome.
FT CHAIN 1..184
FT /note="Tumor necrosis factor alpha-induced protein 8-like
FT protein 2"
FT /id="PRO_0000285772"
SQ SEQUENCE 184 AA; 20615 MW; B72C5E6FDCD592A7 CRC64;
MESFSSKSLA LQAEKKLLSK MAGRSVAHLF IDETSSEVLD ELYRVSKEYT HSRPKAQRVI
KDLIKVAVKV AVLHRSGCFG PGELALATRF RQKLRQGAMT ALSFGEVDFT FEAAVLAGLL
VECRDILLEL VEHHLTPKSH DRIRHVFDHY SDPDLLAALY GPDFTQHLGK ICDGLRKLLD
EGKL
