ID   TP8L2_OTOGA             Reviewed;         184 AA.
AC   B4UT01;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Tumor necrosis factor alpha-induced protein 8-like protein 2;
DE            Short=TIPE2;
DE            Short=TNF alpha-induced protein 8-like protein 2;
DE            Short=TNFAIP8-like protein 2;
GN   Name=TNFAIP8L2;
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii(Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a negative regulator of innate and adaptive immunity
CC       by maintaining immune homeostasis. Negative regulator of Toll-like
CC       receptor and T-cell receptor function. Prevents hyperresponsiveness of
CC       the immune system and maintains immune homeostasis. Inhibits JUN/AP1
CC       and NF-kappa-B activation. Promotes Fas-induced apoptosis (By
CC       similarity). {ECO:0000250}.
CC   -!- DOMAIN: The central region was initially thought to constitute a DED
CC       (death effector) domain. However, 3D-structure data reveal a previously
CC       uncharacterized fold that is different from the predicted fold of a DED
CC       (death effector) domain. It consists of a large, hydrophobic central
CC       cavity that is poised for cofactor binding (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DP000887; ACG76399.1; -; Genomic_DNA.
DR   RefSeq; XP_003800431.1; XM_003800383.1.
DR   AlphaFoldDB; B4UT01; -.
DR   SMR; B4UT01; -.
DR   STRING; 30611.ENSOGAP00000002544; -.
DR   Ensembl; ENSOGAT00000002843; ENSOGAP00000002544; ENSOGAG00000002842.
DR   eggNOG; ENOG502QST4; Eukaryota.
DR   GeneTree; ENSGT00390000003488; -.
DR   HOGENOM; CLU_085918_1_0_1; -.
DR   InParanoid; B4UT01; -.
DR   OMA; IRRVFDH; -.
DR   OrthoDB; 1284744at2759; -.
DR   TreeFam; TF323415; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:0050868; P:negative regulation of T cell activation; IEA:Ensembl.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   GO; GO:0042110; P:T cell activation; IEA:Ensembl.
DR   Gene3D; 1.20.1440.160; -; 1.
DR   InterPro; IPR008477; TNFAIP8-like.
DR   InterPro; IPR038355; TNFAIP8_sf.
DR   PANTHER; PTHR12757; PTHR12757; 1.
DR   Pfam; PF05527; DUF758; 1.
PE   3: Inferred from homology;
KW   Immunity; Innate immunity; Reference proteome.
FT   CHAIN           1..184
FT                   /note="Tumor necrosis factor alpha-induced protein 8-like
FT                   protein 2"
FT                   /id="PRO_0000369393"
SQ   SEQUENCE   184 AA;  20643 MW;  5C24F661FAEDF602 CRC64;
     MESFSSKSLA LQAEKKLLSK MAGRSVAHLF IDETSSEVLD ELYRVSKEYT HSRPQAQRVI
     KDLIKVAVKV AVLHRSGCFG SSELALATRF REKLRQGAMT ALSFGEVDFT FEAAVLADLL
     TECRDVLLEL VERHLTPKSH SRIRHVFDHF SDPGLLTALY GPEFTQHLGK ICDGLRKLLD
     EGKL