ID   TP8L2_RABIT             Reviewed;         184 AA.
AC   B7NZC7;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Tumor necrosis factor alpha-induced protein 8-like protein 2;
DE            Short=TIPE2;
DE            Short=TNF alpha-induced protein 8-like protein 2;
DE            Short=TNFAIP8-like protein 2;
GN   Name=TNFAIP8L2;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Antonellis A., Ayele K., Benjamin B., Blakesley R.W., Boakye A.,
RA   Bouffard G.G., Brinkley C., Brooks S., Chu G., Coleman H., Engle J.,
RA   Gestole M., Greene A., Guan X., Gupta J., Haghighi P., Han J., Hansen N.,
RA   Ho S.-L., Hu P., Hunter G., Hurle B., Idol J.R., Kwong P., Laric P.,
RA   Larson S., Lee-Lin S.-Q., Legaspi R., Madden M., Maduro Q.L., Maduro V.B.,
RA   Margulies E.H., Masiello C., Maskeri B., McDowell J., Mojidi H.A.,
RA   Mullikin J.C., Oestreicher J.S., Park M., Portnoy M.E., Prasad A., Puri O.,
RA   Reddix-Dugue N., Schandler K., Schueler M.G., Sison C., Stantripop S.,
RA   Stephen E., Taye A., Thomas J.W., Thomas P.J., Tsipouri V., Ung L.,
RA   Vogt J.L., Wetherby K.D., Young A., Green E.D.;
RT   "NISC comparative sequencing initiative.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a negative regulator of innate and adaptive immunity
CC       by maintaining immune homeostasis. Negative regulator of Toll-like
CC       receptor and T-cell receptor function. Prevents hyperresponsiveness of
CC       the immune system and maintains immune homeostasis. Inhibits JUN/AP1
CC       and NF-kappa-B activation. Promotes Fas-induced apoptosis (By
CC       similarity). {ECO:0000250}.
CC   -!- DOMAIN: The central region was initially thought to constitute a DED
CC       (death effector) domain. However, 3D-structure data reveal a previously
CC       uncharacterized fold that is different from the predicted fold of a DED
CC       (death effector) domain. It consists of a large, hydrophobic central
CC       cavity that is poised for cofactor binding (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DP001034; ACJ74009.1; -; Genomic_DNA.
DR   RefSeq; NP_001164767.1; NM_001171296.1.
DR   RefSeq; XP_008262236.1; XM_008264014.2.
DR   RefSeq; XP_008262237.1; XM_008264015.2.
DR   RefSeq; XP_017200998.1; XM_017345509.1.
DR   AlphaFoldDB; B7NZC7; -.
DR   SMR; B7NZC7; -.
DR   STRING; 9986.ENSOCUP00000004072; -.
DR   Ensembl; ENSOCUT00000004713; ENSOCUP00000004072; ENSOCUG00000004719.
DR   GeneID; 100328663; -.
DR   KEGG; ocu:100328663; -.
DR   CTD; 79626; -.
DR   eggNOG; ENOG502QST4; Eukaryota.
DR   GeneTree; ENSGT00390000003488; -.
DR   HOGENOM; CLU_085918_1_0_1; -.
DR   InParanoid; B7NZC7; -.
DR   OMA; IRRVFDH; -.
DR   OrthoDB; 1284744at2759; -.
DR   TreeFam; TF323415; -.
DR   Proteomes; UP000001811; Chromosome 13.
DR   Bgee; ENSOCUG00000004719; Expressed in blood and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:0050868; P:negative regulation of T cell activation; IEA:Ensembl.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   GO; GO:0042110; P:T cell activation; IEA:Ensembl.
DR   Gene3D; 1.20.1440.160; -; 1.
DR   InterPro; IPR008477; TNFAIP8-like.
DR   InterPro; IPR038355; TNFAIP8_sf.
DR   PANTHER; PTHR12757; PTHR12757; 1.
DR   Pfam; PF05527; DUF758; 1.
PE   3: Inferred from homology;
KW   Immunity; Innate immunity; Reference proteome.
FT   CHAIN           1..184
FT                   /note="Tumor necrosis factor alpha-induced protein 8-like
FT                   protein 2"
FT                   /id="PRO_0000369395"
SQ   SEQUENCE   184 AA;  20522 MW;  64AD6FD07794CC30 CRC64;
     MESFSSKSLA LQAEKKLLSK MVGRSAAHLF IDETSSEVLD ELYRVSKEYT HSRPQAQRVI
     KDLIKVAVKV AVLHRSGCFG PSELALATRF RQKLRQGAMT ALSFGEVDFT FEAAVLAGLL
     TECRDVLLEL VENHLTPKSH GRIRHVFDHF SDPGLLTALY GPDFTQHLGK ICDGLRKLLE
     EGKL