TP8L2_RAT
ID TP8L2_RAT Reviewed; 184 AA.
AC Q6AYJ8;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Tumor necrosis factor alpha-induced protein 8-like protein 2;
DE Short=TIPE2;
DE Short=TNF alpha-induced protein 8-like protein 2;
DE Short=TNFAIP8-like protein 2;
GN Name=Tnfaip8l2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Acts as a negative regulator of innate and adaptive immunity
CC by maintaining immune homeostasis. Negative regulator of Toll-like
CC receptor and T-cell receptor function. Prevents hyperresponsiveness of
CC the immune system and maintains immune homeostasis. Inhibits JUN/AP1
CC and NF-kappa-B activation. Promotes Fas-induced apoptosis (By
CC similarity). {ECO:0000250}.
CC -!- DOMAIN: The central region was initially thought to constitute a DED
CC (death effector) domain. However, 3D-structure data reveal a previously
CC uncharacterized fold that is different from the predicted fold of a DED
CC (death effector) domain. It consists of a large, hydrophobic central
CC cavity that is poised for cofactor binding (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
CC {ECO:0000305}.
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DR EMBL; BC079019; AAH79019.1; -; mRNA.
DR RefSeq; NP_001014061.1; NM_001014039.1.
DR AlphaFoldDB; Q6AYJ8; -.
DR SMR; Q6AYJ8; -.
DR STRING; 10116.ENSRNOP00000028642; -.
DR PhosphoSitePlus; Q6AYJ8; -.
DR PaxDb; Q6AYJ8; -.
DR Ensembl; ENSRNOT00000028642; ENSRNOP00000028642; ENSRNOG00000021100.
DR Ensembl; ENSRNOT00000116833; ENSRNOP00000094344; ENSRNOG00000021100.
DR GeneID; 310663; -.
DR KEGG; rno:310663; -.
DR UCSC; RGD:1310519; rat.
DR CTD; 79626; -.
DR RGD; 1310519; Tnfaip8l2.
DR eggNOG; ENOG502QST4; Eukaryota.
DR GeneTree; ENSGT00390000003488; -.
DR HOGENOM; CLU_085918_1_0_1; -.
DR InParanoid; Q6AYJ8; -.
DR OMA; IRRVFDH; -.
DR OrthoDB; 1284744at2759; -.
DR PhylomeDB; Q6AYJ8; -.
DR TreeFam; TF323415; -.
DR Reactome; R-RNO-1483255; PI Metabolism.
DR PRO; PR:Q6AYJ8; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000021100; Expressed in spleen and 19 other tissues.
DR Genevisible; Q6AYJ8; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0050728; P:negative regulation of inflammatory response; ISO:RGD.
DR GO; GO:0050868; P:negative regulation of T cell activation; ISO:RGD.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0042110; P:T cell activation; IEA:Ensembl.
DR Gene3D; 1.20.1440.160; -; 1.
DR InterPro; IPR008477; TNFAIP8-like.
DR InterPro; IPR038355; TNFAIP8_sf.
DR PANTHER; PTHR12757; PTHR12757; 1.
DR Pfam; PF05527; DUF758; 1.
PE 2: Evidence at transcript level;
KW Immunity; Innate immunity; Reference proteome.
FT CHAIN 1..184
FT /note="Tumor necrosis factor alpha-induced protein 8-like
FT protein 2"
FT /id="PRO_0000285773"
SQ SEQUENCE 184 AA; 20751 MW; 0BA259B65B54D2BE CRC64;
MESFSSKSLA LQAEKKLLSK MAGRSVAHLF IDETSSEVLD ELYRVSKEYT HSRSKAQRVI
KDLIKVAVKV AVLHRSGCFS PGELALATRF RQKLRQGAMT ALSFGEVDFT FEAAVLAGLL
IECREILLEL VEHHLTPKSH DRIRHVFDHY SDPDLLTALY GPDFTQHLDK ICDGLRKLLD
EGKL
