ID   TP8L2_SALSA             Reviewed;         186 AA.
AC   B5X737;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 29.
DE   RecName: Full=Tumor necrosis factor alpha-induced protein 8-like protein 2;
DE            Short=TIPE2;
DE            Short=TNF alpha-induced protein 8-like protein 2;
DE            Short=TNFAIP8-like protein 2;
GN   Name=tnfaip8l2;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA   Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA   Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA   Koop B.F.;
RT   "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT   evolutionary pressures on a post-tetraploidization genome.";
RL   BMC Genomics 11:279-279(2010).
CC   -!- FUNCTION: Acts as a negative regulator of innate and adaptive immunity
CC       by maintaining immune homeostasis. Negative regulator of Toll-like
CC       receptor and T-cell receptor function. Prevents hyperresponsiveness of
CC       the immune system and maintains immune homeostasis. Inhibits jun/ap1
CC       and NF-kappa-B activation. Promotes Fas-induced apoptosis (By
CC       similarity). {ECO:0000250}.
CC   -!- DOMAIN: The central region was initially thought to constitute a DED
CC       (death effector) domain. However, 3D-structure data reveal a previously
CC       uncharacterized fold that is different from the predicted fold of a DED
CC       (death effector) domain. It consists of a large, hydrophobic central
CC       cavity that is poised for cofactor binding (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BT046856; ACI66657.1; -; mRNA.
DR   RefSeq; NP_001134219.1; NM_001140747.1.
DR   RefSeq; XP_013996982.1; XM_014141507.1.
DR   AlphaFoldDB; B5X737; -.
DR   SMR; B5X737; -.
DR   GeneID; 100195718; -.
DR   KEGG; sasa:100195718; -.
DR   CTD; 100195718; -.
DR   OrthoDB; 1284744at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa14.
DR   Bgee; ENSSSAG00000068313; Expressed in head kidney and 13 other tissues.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   Gene3D; 1.20.1440.160; -; 1.
DR   InterPro; IPR008477; TNFAIP8-like.
DR   InterPro; IPR038355; TNFAIP8_sf.
DR   PANTHER; PTHR12757; PTHR12757; 1.
DR   Pfam; PF05527; DUF758; 1.
PE   2: Evidence at transcript level;
KW   Immunity; Innate immunity; Reference proteome.
FT   CHAIN           1..186
FT                   /note="Tumor necrosis factor alpha-induced protein 8-like
FT                   protein 2"
FT                   /id="PRO_0000369398"
SQ   SEQUENCE   186 AA;  21299 MW;  1E94F52F67C628CE CRC64;
     MESFSSKDMA MKAQKKILSH MASKSMVQML IDDTSSEILD ELYRISKEHS GNRTEAQKVV
     KDLVKVVVKV GVLFRHNRFS KEELSLAQDF KKKLHQGVMT AISFQEVEFT FDKAVMTELL
     TDCRDILLKL VEKHLTLKSF GRIRHVFNHY SDPDLLTNLY TPGGPLWPNL TKICNGLNKL
     VEEGKL