ID   TP8L2_XENLA             Reviewed;         186 AA.
AC   Q6P7I6;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Tumor necrosis factor alpha-induced protein 8-like protein 2;
DE            Short=TIPE2;
DE            Short=TNF alpha-induced protein 8-like protein 2;
DE            Short=TNFAIP8-like protein 2;
GN   Name=tnfaip8l2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a negative regulator of innate and adaptive immunity
CC       by maintaining immune homeostasis. Negative regulator of Toll-like
CC       receptor and T-cell receptor function. Prevents hyperresponsiveness of
CC       the immune system and maintains immune homeostasis. Inhibits jun/ap1
CC       and NF-kappa-B activation. Promotes Fas-induced apoptosis (By
CC       similarity). {ECO:0000250}.
CC   -!- DOMAIN: The central region was initially thought to constitute a DED
CC       (death effector) domain. However, 3D-structure data reveal a previously
CC       uncharacterized fold that is different from the predicted fold of a DED
CC       (death effector) domain. It consists of a large, hydrophobic central
CC       cavity that is poised for cofactor binding (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC061657; AAH61657.1; -; mRNA.
DR   RefSeq; NP_001083608.1; NM_001090139.1.
DR   RefSeq; XP_018084258.1; XM_018228769.1.
DR   AlphaFoldDB; Q6P7I6; -.
DR   SMR; Q6P7I6; -.
DR   DNASU; 399018; -.
DR   GeneID; 399018; -.
DR   KEGG; xla:399018; -.
DR   CTD; 399018; -.
DR   Xenbase; XB-GENE-1005120; tnfaip8l2.L.
DR   OMA; IRRVFDH; -.
DR   OrthoDB; 1284744at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 399018; Expressed in spleen and 19 other tissues.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   Gene3D; 1.20.1440.160; -; 1.
DR   InterPro; IPR008477; TNFAIP8-like.
DR   InterPro; IPR038355; TNFAIP8_sf.
DR   PANTHER; PTHR12757; PTHR12757; 1.
DR   Pfam; PF05527; DUF758; 1.
PE   2: Evidence at transcript level;
KW   Immunity; Innate immunity; Reference proteome.
FT   CHAIN           1..186
FT                   /note="Tumor necrosis factor alpha-induced protein 8-like
FT                   protein 2"
FT                   /id="PRO_0000285775"
SQ   SEQUENCE   186 AA;  21656 MW;  19AEA8998F2E04C1 CRC64;
     METFSSKDLA LQAQKKILSR MASKSMVNMF IDETSSEILD ELYRVSKEYT KNKTESQKVI
     KNLIKIAVKI GVLFRHNRFS PEELVLAKDF KNRLHNGAMT AISFYEVEFT FEKDVLPEIL
     MECKNLVLRL VEKHLTPKSH GRIQHVFNHF ADPEMLSQLY DTKSSLRPHL QKICNGLNKL
     IEEEKL