ID   TP8L2_XENTR             Reviewed;         186 AA.
AC   Q5BKH4;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Tumor necrosis factor alpha-induced protein 8-like protein 2;
DE            Short=TIPE2;
DE            Short=TNF alpha-induced protein 8-like protein 2;
DE            Short=TNFAIP8-like protein 2;
GN   Name=tnfaip8l2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a negative regulator of innate and adaptive immunity
CC       by maintaining immune homeostasis. Negative regulator of Toll-like
CC       receptor and T-cell receptor function. Prevents hyperresponsiveness of
CC       the immune system and maintains immune homeostasis. Inhibits jun/ap1
CC       and NF-kappa-B activation. Promotes Fas-induced apoptosis (By
CC       similarity). {ECO:0000250}.
CC   -!- DOMAIN: The central region was initially thought to constitute a DED
CC       (death effector) domain. However, 3D-structure data reveal a previously
CC       uncharacterized fold that is different from the predicted fold of a DED
CC       (death effector) domain. It consists of a large, hydrophobic central
CC       cavity that is poised for cofactor binding (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC091073; AAH91073.1; -; mRNA.
DR   RefSeq; NP_001025614.1; NM_001030443.1.
DR   RefSeq; XP_012825293.1; XM_012969839.1.
DR   RefSeq; XP_012825294.1; XM_012969840.1.
DR   RefSeq; XP_012825295.1; XM_012969841.1.
DR   RefSeq; XP_012825296.1; XM_012969842.1.
DR   AlphaFoldDB; Q5BKH4; -.
DR   SMR; Q5BKH4; -.
DR   STRING; 8364.ENSXETP00000017843; -.
DR   PaxDb; Q5BKH4; -.
DR   DNASU; 595002; -.
DR   Ensembl; ENSXETT00000017843; ENSXETP00000017843; ENSXETG00000008142.
DR   GeneID; 595002; -.
DR   KEGG; xtr:595002; -.
DR   CTD; 79626; -.
DR   Xenbase; XB-GENE-1005115; tnfaip8l2.
DR   eggNOG; ENOG502QST4; Eukaryota.
DR   HOGENOM; CLU_085918_1_0_1; -.
DR   InParanoid; Q5BKH4; -.
DR   OMA; HDRISHV; -.
DR   OrthoDB; 1284744at2759; -.
DR   PhylomeDB; Q5BKH4; -.
DR   TreeFam; TF323415; -.
DR   Reactome; R-XTR-1483255; PI Metabolism.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000008142; Expressed in liver and 9 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; IBA:GO_Central.
DR   GO; GO:0050868; P:negative regulation of T cell activation; IBA:GO_Central.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   Gene3D; 1.20.1440.160; -; 1.
DR   InterPro; IPR008477; TNFAIP8-like.
DR   InterPro; IPR038355; TNFAIP8_sf.
DR   PANTHER; PTHR12757; PTHR12757; 1.
DR   Pfam; PF05527; DUF758; 1.
PE   2: Evidence at transcript level;
KW   Immunity; Innate immunity; Reference proteome.
FT   CHAIN           1..186
FT                   /note="Tumor necrosis factor alpha-induced protein 8-like
FT                   protein 2"
FT                   /id="PRO_0000285776"
SQ   SEQUENCE   186 AA;  21536 MW;  6EF3D52685126F21 CRC64;
     METFSSKDLA LQAQKKILSR MASKSMVNMF IDETSSEILD ELYRVSKEYT KNKSESQKVI
     KNLIKIAVKI GVLFRHNRFS PEELVLAQDF KSKLHNGAMT AISFYEVEFT FEKDVLPDIL
     MECKNLLLRL VEKHLTPKSH GRIQHVFNHF ADPEMLCQLY DPKGSLWPHL QKICHGLNKL
     IDEGKL