TP8L3_DANRE
ID TP8L3_DANRE Reviewed; 202 AA.
AC Q7T3D0;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Tumor necrosis factor alpha-induced protein 8-like protein 3;
DE Short=TNF alpha-induced protein 8-like protein 3;
DE Short=TNFAIP8-like protein 3;
GN Name=tnfaip8l3; ORFNames=si:ch211-12a1.1, zgc:63960;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May act as a lipid transfer protein.
CC {ECO:0000250|UniProtKB:Q3TBL6}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3TBL6}. Cell
CC membrane {ECO:0000250|UniProtKB:Q3TBL6}.
CC -!- SIMILARITY: Belongs to the TNFAIP8 family. {ECO:0000305}.
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DR EMBL; BX908722; CAK04220.1; -; Genomic_DNA.
DR EMBL; BX927313; CAK04220.1; JOINED; Genomic_DNA.
DR EMBL; BX927313; CAM56316.1; -; Genomic_DNA.
DR EMBL; BX908722; CAM56316.1; JOINED; Genomic_DNA.
DR EMBL; BC053167; AAH53167.1; -; mRNA.
DR RefSeq; NP_956645.1; NM_200351.1.
DR AlphaFoldDB; Q7T3D0; -.
DR SMR; Q7T3D0; -.
DR STRING; 7955.ENSDARP00000112471; -.
DR PaxDb; Q7T3D0; -.
DR PRIDE; Q7T3D0; -.
DR DNASU; 393322; -.
DR Ensembl; ENSDART00000125116; ENSDARP00000112471; ENSDARG00000088709.
DR GeneID; 393322; -.
DR KEGG; dre:393322; -.
DR CTD; 388121; -.
DR ZFIN; ZDB-GENE-040426-1313; tnfaip8l3.
DR eggNOG; ENOG502QRE6; Eukaryota.
DR GeneTree; ENSGT00390000003488; -.
DR HOGENOM; CLU_085918_1_0_1; -.
DR InParanoid; Q7T3D0; -.
DR OMA; RMCEGIN; -.
DR OrthoDB; 1284744at2759; -.
DR PhylomeDB; Q7T3D0; -.
DR TreeFam; TF323415; -.
DR Reactome; R-DRE-1483255; PI Metabolism.
DR PRO; PR:Q7T3D0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 18.
DR Bgee; ENSDARG00000088709; Expressed in head kidney and 21 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR Gene3D; 1.20.1440.160; -; 1.
DR InterPro; IPR008477; TNFAIP8-like.
DR InterPro; IPR038355; TNFAIP8_sf.
DR PANTHER; PTHR12757; PTHR12757; 1.
DR Pfam; PF05527; DUF758; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cytoplasm; Lipid transport; Membrane; Reference proteome;
KW Transport.
FT CHAIN 1..202
FT /note="Tumor necrosis factor alpha-induced protein 8-like
FT protein 3"
FT /id="PRO_0000331426"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 202 AA; 23200 MW; C18FEB0342213D5F CRC64;
MDSDSGEQSE GELSPGHESF NSKSLALQAQ KKILSKMATM AVANLLTDDT SSEILDELYK
ASREYTKSKK EAHKIIKDVI KIALKIGILY RNHQFSPEEM ETVERFKKKM NQAAMTVVSF
YEVEYTFDRG ILSELLLECR DLLHELVEHH LTMRSHGRID HVFNHFADVD FLTELYGPSE
DYRLNLRKIC DGINKLLDEG TL
