ID   TPAN2_PANIM             Reviewed;           4 AA.
AC   P84464;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   23-FEB-2022, entry version 31.
DE   RecName: Full=Tetrapandin-2;
OS   Pandinus imperator (Emperor scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Iurida; Scorpionoidea; Scorpionidae; Pandininae; Pandinus.
OX   NCBI_TaxID=55084;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=14583617; DOI=10.1074/jbc.m308234200;
RA   Shalabi A., Zamudio F., Wu X., Scaloni A., Possani L.D., Villereal M.L.;
RT   "Tetrapandins, a new class of scorpion toxins that specifically inhibit
RT   store-operated calcium entry in human embryonic kidney-293 cells.";
RL   J. Biol. Chem. 279:1040-1049(2004).
CC   -!- FUNCTION: Specific inhibitor of store-operated non-voltage-gated
CC       calcium channels. {ECO:0000269|PubMed:14583617}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14583617}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=546.6; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:14583617};
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Calcium channel impairing toxin; Direct protein sequencing;
KW   Ion channel impairing toxin; Secreted; Toxin.
FT   PEPTIDE         1..4
FT                   /note="Tetrapandin-2"
FT                   /id="PRO_0000044548"
SQ   SEQUENCE   4 AA;  547 MW;  71A3237740000000 CRC64;
     LWKT