BTUB_VIBC3
ID BTUB_VIBC3 Reviewed; 611 AA.
AC A5F4P6; C3M1T5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Vitamin B12 transporter BtuB {ECO:0000255|HAMAP-Rule:MF_01531};
DE AltName: Full=Cobalamin receptor {ECO:0000255|HAMAP-Rule:MF_01531};
DE AltName: Full=Outer membrane cobalamin translocator {ECO:0000255|HAMAP-Rule:MF_01531};
DE Flags: Precursor;
GN Name=btuB {ECO:0000255|HAMAP-Rule:MF_01531};
GN OrderedLocusNames=VC0395_A2342, VC395_0005;
OS Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS O395).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=345073;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA Heidelberg J.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA Wang W., Wang J., Qian W., Li D., Wang L.;
RT "A recalibrated molecular clock and independent origins for the cholera
RT pandemic clones.";
RL PLoS ONE 3:E4053-E4053(2008).
CC -!- FUNCTION: Involved in the active translocation of vitamin B12
CC (cyanocobalamin) across the outer membrane to the periplasmic space. It
CC derives its energy for transport by interacting with the trans-
CC periplasmic membrane protein TonB. {ECO:0000255|HAMAP-Rule:MF_01531}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC Rule:MF_01531}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01531}.
CC -!- SIMILARITY: Belongs to the TonB-dependent receptor family. BtuB (TC
CC 1.B.14.3.1) subfamily. {ECO:0000255|HAMAP-Rule:MF_01531}.
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DR EMBL; CP000627; ABQ21265.1; -; Genomic_DNA.
DR EMBL; CP001235; ACP08034.1; -; Genomic_DNA.
DR RefSeq; WP_001172310.1; NZ_JAACZH010000037.1.
DR AlphaFoldDB; A5F4P6; -.
DR SMR; A5F4P6; -.
DR STRING; 345073.VC395_0005; -.
DR EnsemblBacteria; ABQ21265; ABQ21265; VC0395_A2342.
DR GeneID; 57741351; -.
DR KEGG; vco:VC0395_A2342; -.
DR KEGG; vcr:VC395_0005; -.
DR PATRIC; fig|345073.21.peg.4; -.
DR eggNOG; COG4206; Bacteria.
DR HOGENOM; CLU_008287_18_5_6; -.
DR OMA; SYELQWR; -.
DR Proteomes; UP000000249; Chromosome 2.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:InterPro.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR Gene3D; 2.170.130.10; -; 1.
DR Gene3D; 2.40.170.20; -; 1.
DR HAMAP; MF_01531; BtuB; 1.
DR InterPro; IPR010101; B12_transptr_BtuB.
DR InterPro; IPR039426; BtuB-like.
DR InterPro; IPR012910; Plug_dom.
DR InterPro; IPR037066; Plug_dom_sf.
DR InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR InterPro; IPR010916; TonB_box_CS.
DR InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR InterPro; IPR010917; TonB_rcpt_CS.
DR PANTHER; PTHR30069; PTHR30069; 1.
DR Pfam; PF07715; Plug; 1.
DR Pfam; PF00593; TonB_dep_Rec; 1.
DR TIGRFAMs; TIGR01779; TonB-B12; 1.
DR PROSITE; PS00430; TONB_DEPENDENT_REC_1; 1.
DR PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Ion transport; Membrane; Porin; Signal; TonB box;
KW Transmembrane; Transmembrane beta strand; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01531"
FT CHAIN 23..611
FT /note="Vitamin B12 transporter BtuB"
FT /id="PRO_1000073547"
FT MOTIF 29..36
FT /note="TonB box"
FT MOTIF 594..611
FT /note="TonB C-terminal box"
SQ SEQUENCE 611 AA; 68610 MW; 0C6D9A9A6A2063BE CRC64;
MQKSALAIAL ASLLTPISYL HANEAQPQET VVVTANRFEQ KASSTLADVE IITRQDIEQT
QAKTLPELLR RLTGVQITQN GGRGQLASLF VRGTSSDQVL VLVDGIRFAR AAKGAVDFNQ
IPLTYVDRIE YVRGARASLY GSEAIGGVIN IITKARSQQQ GTTVSAGLGS LDYQELSIAS
GVAIGEKGQM NVALGTESDK GYNVRPVPGV NDGDRHGFRS DNALLGYVHQ FDESWSLFAN
ARAYENIYQY DNSYGTRDYK EAEKDDLSFT IGTQYQSERW VSELQLTTQK QKSWDYTQSK
GKYSDTSDNL EQRNIQWINR YLVNDVWTFA GGVDWRDESY IDKTADKEFD RSNTAAFAVV
AAEWQQWLLE ASLRFDDNQE YGSQTTHNIA LGYQFIPEFG VKASYGSAFK APNLYQQYDP
SYGNVNLQPE DADSAELSFY GLFSGIKWSI TGYDYKINNL IDYNSTTKNY QNVIGESNIK
GVEFTAEFAT GIVQHQLSVD LKDADDSKGK TLQRRAEHMY KWNALVAFEQ VDWSIGYQYV
GKRPDLDYNT YPTQNITLDA YSLVDTSVSY YVTDSTTISA RIDNLLDKEY ETANGYPAAE
RAYYLNIGYQ F
