ID   TPBGL_HUMAN             Reviewed;         382 AA.
AC   P0DKB5;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Trophoblast glycoprotein-like;
DE   Flags: Precursor;
GN   Name=TPBGL;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
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DR   EMBL; AP001972; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS60895.1; -.
DR   RefSeq; NP_001182457.1; NM_001195528.1.
DR   AlphaFoldDB; P0DKB5; -.
DR   SMR; P0DKB5; -.
DR   IntAct; P0DKB5; 1.
DR   STRING; 9606.ENSP00000474988; -.
DR   GlyGen; P0DKB5; 1 site.
DR   PhosphoSitePlus; P0DKB5; -.
DR   BioMuta; TPBGL; -.
DR   DMDM; 408407564; -.
DR   MassIVE; P0DKB5; -.
DR   PeptideAtlas; P0DKB5; -.
DR   PRIDE; P0DKB5; -.
DR   DNASU; 100507050; -.
DR   Ensembl; ENST00000562197.3; ENSP00000474988.1; ENSG00000261594.4.
DR   GeneID; 100507050; -.
DR   KEGG; hsa:100507050; -.
DR   MANE-Select; ENST00000562197.3; ENSP00000474988.1; NM_001195528.2; NP_001182457.1.
DR   UCSC; uc021qnk.2; human.
DR   CTD; 100507050; -.
DR   GeneCards; TPBGL; -.
DR   HGNC; HGNC:44159; TPBGL.
DR   HPA; ENSG00000261594; Group enriched (brain, testis).
DR   neXtProt; NX_P0DKB5; -.
DR   OpenTargets; ENSG00000261594; -.
DR   VEuPathDB; HostDB:ENSG00000261594; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000163536; -.
DR   HOGENOM; CLU_064866_0_0_1; -.
DR   InParanoid; P0DKB5; -.
DR   OMA; APCPFQC; -.
DR   OrthoDB; 785938at2759; -.
DR   PhylomeDB; P0DKB5; -.
DR   PathwayCommons; P0DKB5; -.
DR   SignaLink; P0DKB5; -.
DR   BioGRID-ORCS; 100507050; 23 hits in 1044 CRISPR screens.
DR   GenomeRNAi; 100507050; -.
DR   Pharos; P0DKB5; Tdark.
DR   PRO; PR:P0DKB5; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; P0DKB5; protein.
DR   Bgee; ENSG00000261594; Expressed in dorsal root ganglion and 113 other tissues.
DR   Genevisible; P0DKB5; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00369; LRR_TYP; 3.
DR   SMART; SM00082; LRRCT; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Leucine-rich repeat; Membrane;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..382
FT                   /note="Trophoblast glycoprotein-like"
FT                   /id="PRO_0000419456"
FT   TOPO_DOM        27..307
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        329..382
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REPEAT          57..80
FT                   /note="LRR 1"
FT   REPEAT          93..116
FT                   /note="LRR 2"
FT   REPEAT          117..140
FT                   /note="LRR 3"
FT   REPEAT          171..194
FT                   /note="LRR 4"
FT   REPEAT          196..217
FT                   /note="LRR 5"
FT   REGION          358..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        27..33
FT                   /evidence="ECO:0000250"
FT   DISULFID        31..43
FT                   /evidence="ECO:0000250"
FT   DISULFID        238..264
FT                   /evidence="ECO:0000250"
FT   DISULFID        240..285
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   382 AA;  40400 MW;  405A0F61DC8C751F CRC64;
     MAPRAGQPGL QGLLLVAAAL SQPAAPCPFQ CYCFGGPKLL LRCASGAELR QPPRDVPPDA
     RNLTIVGANL TVLRAAAFAG GDGDGDQAAG VRLPLLSALR LTHNHIEVVE DGAFDGLPSL
     AALDLSHNPL RALGGGAFRG LPALRSLQLN HALVRGGPAL LAALDAALAP LAELRLLGLA
     GNALSRLPPA ALRLARLEQL DVRLNALAGL DPDELRALER DGGLPGPRLL LADNPLRCGC
     AARPLLAWLR NATERVPDSR RLRCAAPRAL LDRPLLDLDG ARLRCADSGA DARGEEAEAA
     GPELEASYVF FGLVLALIGL IFLMVLYLNR RGIQRWMRNL REACRDQMEG YHYRYEQDAD
     PRRAPAPAAP AGSRATSPGS GL