TPC10_DICDI
ID TPC10_DICDI Reviewed; 1442 AA.
AC Q556Z3; Q86AI7;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Trafficking protein particle complex subunit 10;
DE AltName: Full=Trafficking protein particle complex subunit TMEM1;
DE AltName: Full=Transport protein particle subunit TMEM1;
DE Short=TRAPP subunit TMEM1;
GN Name=trapcc10-1; Synonyms=tmem1-1; ORFNames=DDB_G0273209;
GN and
GN Name=trapcc10-2; Synonyms=tmem1-2; ORFNames=DDB_G0273719;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May play a role in vesicular transport from endoplasmic
CC reticulum to Golgi. {ECO:0000250}.
CC -!- SUBUNIT: Part of the multisubunit TRAPP (transport protein particle)
CC complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TMEM1 family. {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AAFI02000011; EAL70550.1; -; Genomic_DNA.
DR EMBL; AAFI02000009; EAL70822.1; -; Genomic_DNA.
DR RefSeq; XP_644476.1; XM_639384.1.
DR RefSeq; XP_644774.1; XM_639682.1.
DR AlphaFoldDB; Q556Z3; -.
DR STRING; 44689.DDB0231693; -.
DR PaxDb; Q556Z3; -.
DR EnsemblProtists; EAL70550; EAL70550; DDB_G0273719.
DR EnsemblProtists; EAL70822; EAL70822; DDB_G0273209.
DR GeneID; 8618876; -.
DR GeneID; 8619100; -.
DR KEGG; ddi:DDB_G0273209; -.
DR KEGG; ddi:DDB_G0273719; -.
DR dictyBase; DDB_G0273209; trappc10-1.
DR dictyBase; DDB_G0273719; trappc10-2.
DR eggNOG; KOG1931; Eukaryota.
DR HOGENOM; CLU_006790_0_0_1; -.
DR InParanoid; Q556Z3; -.
DR OMA; DAEFWDD; -.
DR Reactome; R-DDI-204005; COPII-mediated vesicle transport.
DR Reactome; R-DDI-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR PRO; PR:Q556Z3; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:1990071; C:TRAPPII protein complex; IBA:GO_Central.
DR GO; GO:0034498; P:early endosome to Golgi transport; IBA:GO_Central.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR InterPro; IPR022233; TRAPP_II_complex_TRAPPC10_C.
DR InterPro; IPR045126; TRAPPC10/Trs130.
DR PANTHER; PTHR13251; PTHR13251; 1.
DR Pfam; PF12584; TRAPPC10; 1.
PE 3: Inferred from homology;
KW ER-Golgi transport; Golgi apparatus; Reference proteome; Transport.
FT CHAIN 1..1442
FT /note="Trafficking protein particle complex subunit 10"
FT /id="PRO_0000331481"
FT REGION 1..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1208..1238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1316..1335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1422..1442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1442 AA; 162300 MW; 525FD0B8F4A96FA1 CRC64;
MSNVSPNSMN LNGSTSSTAS VNDSGGGGGG GNVTSPTLSS SSASSISNSN SSSSNNLKPS
TQPLSSSSTL NTPTQFSLQH SSSSSSLNNT NIDIIEHITI SYQDESSIWK YIEAELPNHL
PLKNISWKTK TGHTKVVEKM PIEILQYNDE RVKAHYDNQN LYKKPYLYLY LVHCDDPDTY
KNVVRAKIKQ WVTQMTERQQ EWLIVYVSLG PKRFSELTSK LTRTVFDRIK NDFNVKRDRC
CQLRFLDTNN TSSGNNKDKD NDNGGGSSGT GLSTSTKQQD DLWDDFLIKM KEGIISSAEQ
YLTTYEDEIR KMDAKRTTPG WSYQNFFFIK EGLALIYERA QLYEDALMQY FELEVLFGDP
NNRSQFDQIT DEVLQPNSIH CNGNILDTSF KNYRKLIYEN KISLFDFKVY LFARQSKLLF
LLQKPIEAAT KSISFITSMS MIIKQYPNSF APMFKESWIF STSMELIKAC QDSFDKIVNG
AQQQQQQQQQ QLQLQQQLQQ QQQQQTINGS AQKVVKSISS TTPISKLFGA FGPFGSSSSN
TPSSTSATTA ANGKNTPMPS NSGIASLSAG GSTIIAGLSG SQSLNNLQSA QLSGALNTQH
YIRTPSLNLT SDLSERLTEK QDRESLDFLV GDLLFSSAQR LEELAIIIGY LPVDDYNSEM
FFQNVEEVIF KSVENKKIEV DSMTAFSYQP LQVSLQSSKQ FTQLYFELLG QIEKLYIQSN
RMRSISRLTF AIANLNFKLK EFQIAENLFK SISNLYSREH WSYIEYAVKT RLSYCQKQLG
HLVDYVTTCV GLLAPGLLTN RFEKDHYLSE IIQISRKPEL NIVQPMIPLF KCKVTFKETV
YRYFETIKIN VRIKSNLISP IRFNNGAVSF VKSGFGDKLV FQLNDFLVEP GVNNFQFTAV
GTTKATFVKD SIWLKIDNLS FGYSLRNADT AIGGGGGGTN TTTTTLPGEI KVIDSESQIT
LESFANSPLL FYSIQYVGIK LHTHSDTIEA GVLTFTSPTG ATIIPTSSVI IIQSDDKTCE
TSSRTINLIN DKLPLSQIGY NQTLEFYLPL MAVNTDTCTH QIRIELQHQK QTKEKFSSSL
VSSILFINPL TIDESVINVN NRLFLKTIIQ CNSPNMIQFN SYSLEGCDSE YQSPEQQQLQ
QQLQQQQQLS LSSSSSSISS ISSKSSQQPN LYYLVKDHNH SLAPNLNLYP GQLVSLIFEI
KKYENESLSS STSPSSATDS SNSNGNNNNN NNNNNHSKND LKLKIKYTSK MPQQDLDRPL
IRECKSLWRD QNEFSWPIKI ELPTYLYQID LSIQSRAYVG TIVLFEIEIT NLKQQQQQQK
ESNNDNGNEK QQKQQQLQYH IVADSQIWMI SGKSKHTFSF NSDTVGEKLK FSCGLIPISS
GSLPIPKVTL VGINNSNISY PKTKNEKIFV YPSPQIYSCH QLQDNNNNNN NSINSQTSTN
KT
