TPC10_DROME
ID TPC10_DROME Reviewed; 1145 AA.
AC Q9VFB7; Q540Y2;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Trafficking protein particle complex subunit 10;
DE AltName: Full=Shal Interactor of Di-Leucine Motif;
DE AltName: Full=Trafficking protein particle complex subunit TMEM1;
DE AltName: Full=Transport protein particle subunit TMEM1;
DE Short=TRAPP subunit TMEM1;
GN Name=SIDL; ORFNames=CG6623;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP FUNCTION, INTERACTION WITH SHAL, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP AND DEVELOPMENTAL STAGE.
RX PubMed=20550966; DOI=10.1016/j.mcn.2010.06.001;
RA Diao F., Chaufty J., Waro G., Tsunoda S.;
RT "SIDL interacts with the dendritic targeting motif of Shal (K(v)4) K+
RT channels in Drosophila.";
RL Mol. Cell. Neurosci. 45:75-83(2010).
CC -!- FUNCTION: May play a role in vesicular transport from endoplasmic
CC reticulum to Golgi (By similarity). Has a role in one of the several
CC mechanisms underlying dendritic localization of Shal channels.
CC {ECO:0000250, ECO:0000269|PubMed:20550966}.
CC -!- SUBUNIT: Part of the multisubunit TRAPP (transport protein particle)
CC complex (By similarity). Interacts with Shal (via C-terminal dendritic
CC targeting motif). {ECO:0000250, ECO:0000269|PubMed:20550966}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}.
CC Cell projection, dendrite {ECO:0000269|PubMed:20550966}. Perikaryon
CC {ECO:0000269|PubMed:20550966}.
CC -!- TISSUE SPECIFICITY: Co-expressed with Shal in the nervous system.
CC {ECO:0000269|PubMed:20550966}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout development from 5 hours
CC after egg laying though to adults. {ECO:0000269|PubMed:20550966}.
CC -!- SIMILARITY: Belongs to the TMEM1 family. {ECO:0000305}.
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DR EMBL; AE014297; AAF55143.1; -; Genomic_DNA.
DR EMBL; AY118591; AAM49960.1; -; mRNA.
DR RefSeq; NP_650431.1; NM_142174.3.
DR AlphaFoldDB; Q9VFB7; -.
DR BioGRID; 66897; 10.
DR IntAct; Q9VFB7; 9.
DR STRING; 7227.FBpp0082592; -.
DR PaxDb; Q9VFB7; -.
DR PRIDE; Q9VFB7; -.
DR DNASU; 41833; -.
DR EnsemblMetazoa; FBtr0083138; FBpp0082592; FBgn0038303.
DR GeneID; 41833; -.
DR KEGG; dme:Dmel_CG6623; -.
DR UCSC; CG6623-RA; d. melanogaster.
DR CTD; 41833; -.
DR FlyBase; FBgn0038303; SIDL.
DR VEuPathDB; VectorBase:FBgn0038303; -.
DR eggNOG; KOG1931; Eukaryota.
DR GeneTree; ENSGT00390000003873; -.
DR HOGENOM; CLU_006893_0_0_1; -.
DR InParanoid; Q9VFB7; -.
DR OMA; TKVHENP; -.
DR OrthoDB; 537782at2759; -.
DR PhylomeDB; Q9VFB7; -.
DR Reactome; R-DME-204005; COPII-mediated vesicle transport.
DR Reactome; R-DME-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR SignaLink; Q9VFB7; -.
DR BioGRID-ORCS; 41833; 0 hits in 1 CRISPR screen.
DR ChiTaRS; SIDL; fly.
DR GenomeRNAi; 41833; -.
DR PRO; PR:Q9VFB7; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0038303; Expressed in embryonic/larval hemocyte (Drosophila) and 25 other tissues.
DR Genevisible; Q9VFB7; DM.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IDA:FlyBase.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0030008; C:TRAPP complex; ISS:FlyBase.
DR GO; GO:1990071; C:TRAPPII protein complex; IDA:FlyBase.
DR GO; GO:0034498; P:early endosome to Golgi transport; IBA:GO_Central.
DR GO; GO:0048193; P:Golgi vesicle transport; IC:FlyBase.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; ISS:FlyBase.
DR GO; GO:0043087; P:regulation of GTPase activity; ISS:FlyBase.
DR InterPro; IPR022233; TRAPP_II_complex_TRAPPC10_C.
DR InterPro; IPR045126; TRAPPC10/Trs130.
DR PANTHER; PTHR13251; PTHR13251; 1.
DR Pfam; PF12584; TRAPPC10; 1.
PE 1: Evidence at protein level;
KW Cell projection; ER-Golgi transport; Golgi apparatus; Reference proteome;
KW Transport.
FT CHAIN 1..1145
FT /note="Trafficking protein particle complex subunit 10"
FT /id="PRO_0000193510"
SQ SEQUENCE 1145 AA; 130804 MW; A55691F51C770E14 CRC64;
MQIKPIITYS GSCPLFRSLE SQILNAIPLD TCEWRRTFQR PTKHVRLEAQ AQQFNVAALE
KYKQGDWSIL EHPILHIFVT ECNDVDTYKA TIREAIDIWL KTLTSYGVSD WMILLVETLD
MRKTKNFMPR TTVLDKIRLD FGTKNDDRCI SVLNPAKFEQ KSTESFRCLV QRIRFLMLTS
YNRNIVKYEE LIRSKREKRN IEGWDFRQYF FMQEDLALIF EKLELPTEAL IQYDELDAMF
SQFITHTGLN EKQQWLNHFR KPLDAFHGIC LTRADKFEMR NKIRDEGVSL LEFRNYLFER
QAYLLLTCND IPEIAKRLLN FLFSTLREVE LIKLECQEGA LCCWEFVCAL EVLQLCEQAM
EPNELTCFQH CAPIWNLAKD KLYELGKLCG LLPGCTPTSE QLHIVVQLSS GIGDAPSEQH
QFLQATPQLR DRSPNRKPKK SGAEQLKEAL GSNQAFQKLY LELAELAIST YKHVTRLRSA
RLVGLDLGNF YCALNEPHKA VGFFTDLLRE LKAENWHMLS SQTLLELANC YRKMGDSLAY
TKTCSSISCC AELETLVRTF YFDEFLKSLK TLKTTLSAQP SIENANYCVL EDHFRILDIE
VVNQKPIIQD DYILVQLKVE SLYPRGVVAE NVKLCYELEA SSLELAMENV SLTASPSTVK
AKDTSSRLKV SLQLVYKQDN RLHSAAVACD LPKSKQPVRR TSSTKRKLSP SVQADFTNFV
QAENIALQPG VNLIEMKAKA TRVGCWQFKQ LCISMSSLEF LSEQLPFMPA TFEISTKPAS
ATLEFKTLIA GIVQPISLNV SGGSFIFPPD AKITLRCSKN LRIRQARNTD DEAAYNDDQS
FESTLQVPLV QFKSFEERRI PLEVLTDMPG RKVSKHHEHH IALNCPWSRT ELPIAVDFQP
AMEATCRLHT CGTQKFLQVI MKGMEAHLLL QHAQVKCDVP GVQLLDLNPE SQQPIEIYKS
LTVTYLYEIQ VEPLKTEHEL PVVKVHFVIK YASLSQPDVW RTYGCAFDLV DYTTLFKLQA
QLEPNELCRL RTVCNMNLKI TKVHENPYTD LMYEVLNDQN LWAVCGRSAG VVSMKDVDSH
SISLDVMPLS TGFLPMPSIR LSKYTAGGKS KTDGHSKVHP FPPGQVYNST KSMQIHVIAS
VAGDQ
