TPC10_MOUSE
ID TPC10_MOUSE Reviewed; 1258 AA.
AC Q3TLI0; F8VQF9; Q811H4;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2021, sequence version 3.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Trafficking protein particle complex subunit 10;
DE AltName: Full=Trafficking protein particle complex subunit TMEM1;
DE AltName: Full=Transport protein particle subunit TMEM1;
DE Short=TRAPP subunit TMEM1;
GN Name=Trappc10; Synonyms=Tmem1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-132.
RC TISSUE=Mammary gland;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 404-1258.
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-707, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [7]
RP IDENTIFICATION IN THE TRAPP II COMPLEX.
RX PubMed=19656848; DOI=10.1091/mbc.e09-05-0387;
RA Yamasaki A., Menon S., Yu S., Barrowman J., Meerloo T., Oorschot V.,
RA Klumperman J., Satoh A., Ferro-Novick S.;
RT "mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that
RT binds to COPI-coated vesicles.";
RL Mol. Biol. Cell 20:4205-4215(2009).
CC -!- FUNCTION: Specific subunit of the TRAPP (transport protein particle) II
CC complex, a highly conserved vesicle tethering complex that functions in
CC late Golgi trafficking as a membrane tether.
CC {ECO:0000250|UniProtKB:P48553}.
CC -!- SUBUNIT: Specific component of the multisubunit TRAPP II complex, which
CC includes at least TRAPPC1, TRAPPC2, TRAPPC3, TRAPPC4, TRAPPC5,
CC TRAPPC6A/B, TRAPPC9, TRAPPC10 and TRAPPC14. TRAPPC9, TRAPPC10 and
CC TRAPPC14 are specific subunits of the TRAPP II complex
CC (PubMed:19656848). Interacts with TRAPPC14 (By similarity).
CC {ECO:0000250|UniProtKB:P48553, ECO:0000269|PubMed:19656848}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TRAPPC10 family. {ECO:0000305}.
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DR EMBL; AK166500; BAE38812.1; -; mRNA.
DR EMBL; BC044902; AAH44902.1; -; mRNA.
DR EMBL; AC164573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS35959.1; -.
DR RefSeq; NP_001074524.1; NM_001081055.1.
DR AlphaFoldDB; Q3TLI0; -.
DR ComplexPortal; CPX-4764; TRAPP II complex.
DR IntAct; Q3TLI0; 1.
DR STRING; 10090.ENSMUSP00000000384; -.
DR iPTMnet; Q3TLI0; -.
DR PhosphoSitePlus; Q3TLI0; -.
DR SwissPalm; Q3TLI0; -.
DR EPD; Q3TLI0; -.
DR jPOST; Q3TLI0; -.
DR MaxQB; Q3TLI0; -.
DR PaxDb; Q3TLI0; -.
DR PRIDE; Q3TLI0; -.
DR ProteomicsDB; 260725; -.
DR ProteomicsDB; 361417; -.
DR DNASU; 216131; -.
DR Ensembl; ENSMUST00000000384; ENSMUSP00000000384; ENSMUSG00000000374.
DR GeneID; 216131; -.
DR KEGG; mmu:216131; -.
DR CTD; 7109; -.
DR MGI; MGI:1336209; Trappc10.
DR VEuPathDB; HostDB:ENSMUSG00000000374; -.
DR eggNOG; KOG1931; Eukaryota.
DR GeneTree; ENSGT00390000003873; -.
DR HOGENOM; CLU_006893_0_0_1; -.
DR InParanoid; Q3TLI0; -.
DR OMA; TKVHENP; -.
DR OrthoDB; 537782at2759; -.
DR PhylomeDB; Q3TLI0; -.
DR TreeFam; TF320954; -.
DR Reactome; R-MMU-204005; COPII-mediated vesicle transport.
DR Reactome; R-MMU-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR BioGRID-ORCS; 216131; 3 hits in 70 CRISPR screens.
DR ChiTaRS; Trappc10; mouse.
DR PRO; PR:Q3TLI0; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q3TLI0; protein.
DR Bgee; ENSMUSG00000000374; Expressed in paneth cell and 268 other tissues.
DR GO; GO:0005737; C:cytoplasm; IC:ComplexPortal.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0030008; C:TRAPP complex; ISO:MGI.
DR GO; GO:1990071; C:TRAPPII protein complex; IBA:GO_Central.
DR GO; GO:0034498; P:early endosome to Golgi transport; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IC:ComplexPortal.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006901; P:vesicle coating; IC:ComplexPortal.
DR GO; GO:0099022; P:vesicle tethering; IC:ComplexPortal.
DR InterPro; IPR022233; TRAPP_II_complex_TRAPPC10_C.
DR InterPro; IPR045126; TRAPPC10/Trs130.
DR PANTHER; PTHR13251; PTHR13251; 1.
DR Pfam; PF12584; TRAPPC10; 1.
PE 1: Evidence at protein level;
KW ER-Golgi transport; Golgi apparatus; Phosphoprotein; Reference proteome;
KW Transport.
FT CHAIN 1..1258
FT /note="Trafficking protein particle complex subunit 10"
FT /id="PRO_0000331480"
FT REGION 888..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1201..1222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1201..1219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 707
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355"
FT CONFLICT 583
FT /note="Q -> HS (in Ref. 3; AAH44902)"
FT /evidence="ECO:0000305"
FT CONFLICT 682
FT /note="S -> N (in Ref. 3; AAH44902)"
FT /evidence="ECO:0000305"
FT CONFLICT 1046
FT /note="T -> I (in Ref. 3; AAH44902)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1258 AA; 141493 MW; 42C39F12350B4619 CRC64;
MDAPEEPQPP VVYTMENKPI VTCAGDQNLF TSIYPTLSQQ LPREPMEWRR SYGRAPKMIH
LESNFVQFKE ELLPKEGNKA LLTFPFLHIY WTECCDTEVY KATVKDDLTK WQNVLKAHSS
VDWLIVVVEN DAKKKNKTNI LPRTSIVDKI RNDFCNKQSD RCVVLSDPLK DSSRTQESWN
AFLTKLRTLL LMSFTKNLGK FEDDMRTLRE KRTEPGWSFC EYFMVQEELA FVFEMLQQFE
DALVQYDELD ALFSQYVVNF GAGDGANWLT FFCQPVKSWN GLVLRKPIDM EKRELIQKQE
ATLLDLRSYL FSRQCTLLLF LQRPWEVAQR ALELLHSCVQ ELKLLEVSVP PGALDCWVFL
SCLEVLQRIE GCCDRAQIDS NIAHMVGLWS YAMEKLKSLG YLCGLVSEKG PNSEDLNRTV
DLLAGLGAER PETANTAQSP YKKLQEALSS VEAFEKHYLD LSHATIEMYT SIGRIRSAKL
VGKDLAEFYM RKRSPQKAEM YLQGALKNYL AEGWALPVTH TRKQLAECQK HLGQMENYLQ
TSSLLASDHH LTEEERKYFC QEILSFASQQ EDNPGHKVVL PMQFARLKDL HFDPPNAVVH
AGGVLTVEIT VCSQMPIPVH VDQIAVNVHF SIEKNNYRKT AEWLTKHKTS NGIITFPAEA
SLFPASQNSL PALELSEMLE RSPSDNSLNT TGIICRNVHM LLRRQESGSS LEPPSGLALE
DGAHVLRCSS VTLQPGANKI AFKTQAKEPG TYTLRQLRAS VGPVWFVLAH IHPIVQYDVY
SQEPQLHVEP LADSLLAGIP QKVKFTVTTG HYTVKNGDSL QLSNVEAMLI LCQAENRAVV
YSNSREECST ALLRIQSSDK VTSIGLPTAP AYHVIEFELE VLSLPSAPAS GGDTSVPGTP
ELHRKQKDSQ RAGHCMVTTD HKVSIDCPWS IYSTVIALTF SVPFRTEHSL LSAGTRKYVQ
VCVQNLSELD FELSDSNLED KGHATDLRLA PLNTQSQQLI HSKQSVFFVW ELTWTQEPPP
PLHCQFSVGF SPASEEQLTV SLKPYTYEFQ VENFFTLYSV RAEILPASGA EYCKTGSLCS
LEVSITRLAD LLDVDKDEAL VESEDYFSTK LMYEVVDNSS NWAVCGKSCG VIAMPLAAQA
THRVHMEVMP LFAGYLPLPD VRLFKYLPHH SAHASQLDAD SWIENDSLSV DKHLDDQLDC
SSLRSRGSTH STSSSEHKGL PMPRLQALPA GQVFNSSTGM QVLVIPSQDD HVLEVSVT
