TPC11_DANRE
ID TPC11_DANRE Reviewed; 1132 AA.
AC Q1RLX4; Q6DRL6; Q6PGX1;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Trafficking protein particle complex subunit 11;
DE AltName: Full=Protein foie gras;
GN Name=trappc11; Synonyms=fgr, foigr; ORFNames=zgc:136723, zgc:63684;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Embryo;
RX PubMed=15256591; DOI=10.1073/pnas.0403929101;
RA Amsterdam A., Nissen R.M., Sun Z., Swindell E.C., Farrington S.,
RA Hopkins N.;
RT "Identification of 315 genes essential for early zebrafish development.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:12792-12797(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=SJD;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP DISRUPTION PHENOTYPE.
RX PubMed=16000385; DOI=10.1242/dev.01918;
RA Sadler K.C., Amsterdam A., Soroka C., Boyer J., Hopkins N.;
RT "A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie
RT gras as models of liver disease.";
RL Development 132:3561-3572(2005).
CC -!- FUNCTION: Involved in endoplasmic reticulum to Golgi apparatus
CC trafficking at a very early stage. {ECO:0000250}.
CC -!- SUBUNIT: Component of the multisubunit TRAPP (transport protein
CC particle) complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:Q7Z392}.
CC Golgi apparatus, cis-Golgi network {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q1RLX4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q1RLX4-2; Sequence=VSP_035103;
CC -!- DISRUPTION PHENOTYPE: Pronounced hepatomegaly accompanied by lipid
CC accumulation in the liver. {ECO:0000269|PubMed:16000385}.
CC -!- SIMILARITY: Belongs to the TRAPPC11 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY648743; AAT68061.1; -; mRNA.
DR EMBL; BC056800; AAH56800.1; -; mRNA.
DR EMBL; BC115242; AAI15243.1; -; mRNA.
DR RefSeq; NP_955920.2; NM_199626.2.
DR RefSeq; XP_005157179.1; XM_005157122.3. [Q1RLX4-1]
DR AlphaFoldDB; Q1RLX4; -.
DR SMR; Q1RLX4; -.
DR STRING; 7955.ENSDARP00000054808; -.
DR PaxDb; Q1RLX4; -.
DR PRIDE; Q1RLX4; -.
DR Ensembl; ENSDART00000054809; ENSDARP00000054808; ENSDARG00000004726. [Q1RLX4-1]
DR GeneID; 323003; -.
DR KEGG; dre:323003; -.
DR CTD; 60684; -.
DR ZFIN; ZDB-GENE-030131-1723; trappc11.
DR eggNOG; KOG4386; Eukaryota.
DR GeneTree; ENSGT00390000006550; -.
DR HOGENOM; CLU_003649_0_0_1; -.
DR InParanoid; Q1RLX4; -.
DR OMA; VFEGCLR; -.
DR OrthoDB; 1065648at2759; -.
DR PhylomeDB; Q1RLX4; -.
DR TreeFam; TF314022; -.
DR Reactome; R-DRE-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR PRO; PR:Q1RLX4; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 14.
DR Bgee; ENSDARG00000004726; Expressed in intestine and 28 other tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0007030; P:Golgi organization; IMP:ZFIN.
DR GO; GO:0055088; P:lipid homeostasis; IGI:ZFIN.
DR GO; GO:0001889; P:liver development; IMP:ZFIN.
DR GO; GO:0006487; P:protein N-linked glycosylation; IMP:ZFIN.
DR GO; GO:0009306; P:protein secretion; IMP:ZFIN.
DR GO; GO:1905897; P:regulation of response to endoplasmic reticulum stress; IGI:ZFIN.
DR GO; GO:0060041; P:retina development in camera-type eye; IMP:ZFIN.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR InterPro; IPR021773; TPC11.
DR InterPro; IPR025876; TRAPPC11_C.
DR Pfam; PF11817; Foie-gras_1; 1.
DR Pfam; PF12742; Gryzun-like; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ER-Golgi transport; Golgi apparatus;
KW Reference proteome; Transport.
FT CHAIN 1..1132
FT /note="Trafficking protein particle complex subunit 11"
FT /id="PRO_0000348075"
FT VAR_SEQ 339..938
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_035103"
FT CONFLICT 5
FT /note="R -> Q (in Ref. 1; AAT68061 and 2; AAH56800)"
FT /evidence="ECO:0000305"
FT CONFLICT 1118
FT /note="V -> I (in Ref. 2; AAH56800)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1132 AA; 128647 MW; EBA227724FE58452 CRC64;
MSPARWDLPP ELCCRPMAFV ALTGLDVVYN AIHRAIWDAF CANRRADRVP ISFKVLPGDH
EYPKCRTKRT SYEWYIPKGI LKTGWMNKHL NLVPALVVLF YELDWDDPQW KEKQSECATK
VEIVRTSLQG RNTKVAVVLI QKKTPLPPGE DLVASERASA LCGACDLSGK SLFVLPHTDH
LVGYIIRLEN AFYEHAQTYY YNEIRRVKSH KEFLNKTTHQ LLFVRHQFKM GFFSELKQDT
QNALKYYRTA YSLVHELRAH ETNVLEIKTM AGFINYKICR LCFQHNTPLD AIAQFRKHID
LCKKKIGSAE LAFEHTAWMS KQFQSFGDLF DEAIKLGLTA IQTQNPGFYY QQAAYYAQER
KQQAGQLCSH EPGVGYPAPD PLETTSGALD FYGQRPWRQG HQSIDPPDSE KEKQGILALQ
VKERDVLHSE LIIALLSNAV AQFKKYKCPR MKSHLMVQMG EEYYHAKDYT KALKLLDYVM
CDYRTERWWS LLTSIVCTAL KCSYLMGQVK DYITYSMELV GRASILSEEQ KSRIEKNLIK
VLMNEVPEPE PDCDPVSVKA AQSLWSDRVS LAGNNEFTID VQDYVPFVQC KAKFLSPSFH
IDEPVQLHVY VRADCPHPVR FSKLCVSLSN QEYNQYCLLE DAYKGKDILE PSSQENMCLV
PGKTRKYCFN FVAKTEDVGK KIEITSVGLM LGRETGRYVY LNWRGGWGDA ASSHESLQAS
RSFKRRTRLP EQHVDWDAVS VQSSTMIISR VPKISVQLTH EPPALTNEMF CMTVTIKSEE
DTVGKDIKLT AGLKPGQDAN LTQSTQITLN GSEVCDDSHP ALLPDIPLGD LQPGQKIVKP
LYIRCVSTGS RIFLFHVAYS VSATVEGKDI TCKCHKDETV TVETVVPFEV AMKFVSSKFE
HLERVYVDIP FLLMMDILSA SPWPIELVES EVQLASSMTA IDQPQSQVEG VTLQTSECAS
ECFLLKCPPV QNGTSTVASG HYIISWKRKS TFTETSVVRT VITLPHVMVE NIPLYVHAEV
PSFGRVRESL PVRYHLENRT GLVQDVEISV EPSDAFMFSG LKQVRMRILP GAEQEMLYNF
YPLMAGYQVL PQLNINLLRF PNISSQLLRR FLPSRIFVKP QGRNGDASIE AA
