TPC11_MOUSE
ID TPC11_MOUSE Reviewed; 1133 AA.
AC B2RXC1; B9EJS1; Q52KP8; Q8BXY8;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Trafficking protein particle complex subunit 11;
GN Name=Trappc11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in endoplasmic reticulum to Golgi apparatus
CC trafficking at a very early stage. {ECO:0000250}.
CC -!- SUBUNIT: Component of the multisubunit TRAPP (transport protein
CC particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3,
CC TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and
CC TRAPPC12. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:Q7Z392}.
CC Golgi apparatus, cis-Golgi network {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=B2RXC1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=B2RXC1-2; Sequence=VSP_035100, VSP_035101, VSP_035102;
CC -!- SIMILARITY: Belongs to the TRAPPC11 family. {ECO:0000305}.
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DR EMBL; AK042816; BAC31370.1; -; mRNA.
DR EMBL; BC094246; AAH94246.1; -; mRNA.
DR EMBL; BC147504; AAI47505.1; -; mRNA.
DR EMBL; BC151159; AAI51160.1; -; mRNA.
DR CCDS; CCDS22296.1; -. [B2RXC1-1]
DR RefSeq; NP_796214.2; NM_177240.3. [B2RXC1-1]
DR AlphaFoldDB; B2RXC1; -.
DR SMR; B2RXC1; -.
DR BioGRID; 236237; 14.
DR ComplexPortal; CPX-4766; TRAPP III complex.
DR IntAct; B2RXC1; 13.
DR STRING; 10090.ENSMUSP00000047562; -.
DR iPTMnet; B2RXC1; -.
DR PhosphoSitePlus; B2RXC1; -.
DR SwissPalm; B2RXC1; -.
DR EPD; B2RXC1; -.
DR jPOST; B2RXC1; -.
DR MaxQB; B2RXC1; -.
DR PaxDb; B2RXC1; -.
DR PeptideAtlas; B2RXC1; -.
DR PRIDE; B2RXC1; -.
DR ProteomicsDB; 260654; -. [B2RXC1-1]
DR ProteomicsDB; 260655; -. [B2RXC1-2]
DR Antibodypedia; 55746; 43 antibodies from 9 providers.
DR DNASU; 320714; -.
DR Ensembl; ENSMUST00000039061; ENSMUSP00000047562; ENSMUSG00000038102. [B2RXC1-1]
DR Ensembl; ENSMUST00000120987; ENSMUSP00000113779; ENSMUSG00000038102. [B2RXC1-2]
DR GeneID; 320714; -.
DR KEGG; mmu:320714; -.
DR UCSC; uc009lra.1; mouse. [B2RXC1-1]
DR UCSC; uc009lrb.1; mouse. [B2RXC1-2]
DR CTD; 60684; -.
DR MGI; MGI:2444585; Trappc11.
DR VEuPathDB; HostDB:ENSMUSG00000038102; -.
DR eggNOG; KOG4386; Eukaryota.
DR GeneTree; ENSGT00390000006550; -.
DR HOGENOM; CLU_003649_0_0_1; -.
DR InParanoid; B2RXC1; -.
DR OMA; VFEGCLR; -.
DR OrthoDB; 1065648at2759; -.
DR PhylomeDB; B2RXC1; -.
DR TreeFam; TF314022; -.
DR Reactome; R-MMU-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR BioGRID-ORCS; 320714; 28 hits in 74 CRISPR screens.
DR ChiTaRS; Trappc11; mouse.
DR PRO; PR:B2RXC1; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; B2RXC1; protein.
DR Bgee; ENSMUSG00000038102; Expressed in manus and 220 other tissues.
DR Genevisible; B2RXC1; MM.
DR GO; GO:0005737; C:cytoplasm; IC:ComplexPortal.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0030008; C:TRAPP complex; ISO:MGI.
DR GO; GO:1990072; C:TRAPPIII protein complex; IC:ComplexPortal.
DR GO; GO:0045054; P:constitutive secretory pathway; ISO:MGI.
DR GO; GO:0048208; P:COPII vesicle coating; IC:ComplexPortal.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISO:MGI.
DR GO; GO:0007030; P:Golgi organization; ISO:MGI.
DR GO; GO:0061635; P:regulation of protein complex stability; ISO:MGI.
DR GO; GO:0099022; P:vesicle tethering; IC:ComplexPortal.
DR InterPro; IPR021773; TPC11.
DR InterPro; IPR025876; TRAPPC11_C.
DR Pfam; PF11817; Foie-gras_1; 1.
DR Pfam; PF12742; Gryzun-like; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; ER-Golgi transport; Golgi apparatus;
KW Reference proteome; Transport.
FT CHAIN 1..1133
FT /note="Trafficking protein particle complex subunit 11"
FT /id="PRO_0000348073"
FT MOD_RES 245
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z392"
FT VAR_SEQ 1..656
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_035100"
FT VAR_SEQ 797..832
FT /note="QDANLTQKTHVTLHGAELCDESYPALLTDIPVGDLH -> EHPLYKFLLGVR
FT WTRSHVLWWLKRQCGLFALLKFAM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_035101"
FT VAR_SEQ 833..1133
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_035102"
SQ SEQUENCE 1133 AA; 128396 MW; 2CF6277990E165CF CRC64;
MSPTQWDFPV ELCCRPMAFV TLTGLDVVYN AVHRAVWDAF CANRRADRVP ISFKVLPGDH
EYPKCRSKRT SYEWYIPKGV LKTGWMNKHL NLVPALVVVF YELDWDEPQW KEKQSECATR
VEIVRQSLQG RNTKVAVVLI QKKTPLPPGE DVIASERAAA LCNVCELSGK SLFVLPHTDH
LVGYIIRLEN AFYEHAQTYY YTEIRRVKSH KEFLNKTTHQ LLFVRHQFKI AFFSELKQDT
QNALKNYRIA YNLVHELRAH ETNILEIKTM AGFINYKICR LCFQHNTPLD AIAQFRKHID
LCKKKIGSAE LAFEHAAWMA KQFQAFGDLF DEAIKLGLTA IQTQNPGFYY QQAAYYAQER
KQHAKALCNH DAAVMYPNPD PLETQSGVLD FYGQRPWRQG ILSFDLSDPE KEKAGILAIQ
LKERSVVHSE IIIALLSNAV AQFKKYKCPR MKSHLMVQMG EEYYYAKDYT KALKLLDYVM
CDYRSEAWWT LLTSILTTAL KCSYLMAQLK DYITYSLELL GRASTLKDEQ KSRIEKNLMN
VLMNESPDPE PDCDVLAVKT AQKLWADRVS LAGSNVFQIG VQDFVPFVQC KAKFHAPSFH
VDVPVEFDVF LKADCPHPIR FSKLCVSFNN QVYNQFCVLE EASKASEVLE NLTQGKMCLV
PGKTRKLSFK FVAKTEDVGK KIEITSVDLF LGSESGRCVV LSWQGGGGDA ASSQEALQAA
RSFKRRPKLA EDEIHWDSVI IQASTMIISR VPNISVHLRH EPPALMNEMY CLVVTVQSHE
KSPIRDVKLT AGLKPGQDAN LTQKTHVTLH GAELCDESYP ALLTDIPVGD LHPGEQLEKT
VYVRCGTVGS RMFLVYVSYL INTTVEGKEI ICKCHKDDTV TIETVFPFDV AVRFVSTKFE
HLERVYADIP FLLMTDVLSA SPWALTIVSS ELQLAPSMTA MDHLESQIDK VVLQTGESAS
ECFCLRCPSA GNIEGGVATG HYIISWKRAS VVESIPAVST VITLPHVIAE NIPLHVNADL
PSFGRVRESL PVRYHLQNKT DLVQDVEISV EPSDAFMFSG LKQIRLRILP GTKQEMLYNF
YPLMAGYQQL PSLNINLLRF PNFTNQLLRR FIPTSIFVKP QGRLLEDTSI AAA
