TPC13_HUMAN
ID TPC13_HUMAN Reviewed; 417 AA.
AC A5PLN9; Q17RZ9; Q49A23; Q4JHG0; Q6MZG4; Q8TCM2; Q9H8I3;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Trafficking protein particle complex subunit 13;
GN Name=TRAPPC13; Synonyms=C5orf44;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 211-417 (ISOFORM 1).
RC TISSUE=Brain, and Small intestine;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 12-417 (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-417 (ISOFORM 4).
RA Li H., Nong W., Zhou G., Ke R., Shen C., Zhong G., Zheng Z., Liang M.,
RA Wen S., Lin L., Yang S.;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP IDENTIFICATION IN TRAPP COMPLEX.
RX PubMed=21453443; DOI=10.1111/j.1600-0854.2011.01181.x;
RA Choi C., Davey M., Schluter C., Pandher P., Fang Y., Foster L.J.,
RA Conibear E.;
RT "Organization and assembly of the TRAPPII complex.";
RL Traffic 12:715-725(2011).
CC -!- SUBUNIT: Part of the multisubunit TRAPP (transport protein particle)
CC complex. {ECO:0000269|PubMed:21453443}.
CC -!- INTERACTION:
CC A5PLN9; O43617: TRAPPC3; NbExp=2; IntAct=EBI-2857298, EBI-743566;
CC A5PLN9; Q9Y2L5: TRAPPC8; NbExp=2; IntAct=EBI-2857298, EBI-2820056;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=A5PLN9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A5PLN9-2; Sequence=VSP_038356;
CC Name=3;
CC IsoId=A5PLN9-4; Sequence=VSP_038356, VSP_038359;
CC Name=4;
CC IsoId=A5PLN9-5; Sequence=VSP_038359;
CC Name=5;
CC IsoId=A5PLN9-7; Sequence=VSP_038356, VSP_038357, VSP_038358;
CC -!- MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TRAPPC13 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH47475.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC Sequence=BAB14633.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL713699; CAD28498.1; -; mRNA.
DR EMBL; BX641157; CAE46070.1; -; mRNA.
DR EMBL; AK023673; BAB14633.1; ALT_SEQ; mRNA.
DR EMBL; AC008560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471137; EAW51346.1; -; Genomic_DNA.
DR EMBL; BC047475; AAH47475.1; ALT_SEQ; mRNA.
DR EMBL; BC117128; AAI17129.1; -; mRNA.
DR EMBL; BC142994; AAI42995.1; -; mRNA.
DR EMBL; DQ088673; AAY88966.1; -; mRNA.
DR CCDS; CCDS47221.1; -. [A5PLN9-5]
DR CCDS; CCDS47222.1; -. [A5PLN9-1]
DR CCDS; CCDS47223.1; -. [A5PLN9-2]
DR CCDS; CCDS58950.1; -. [A5PLN9-4]
DR RefSeq; NP_001087224.1; NM_001093755.1. [A5PLN9-5]
DR RefSeq; NP_001087225.1; NM_001093756.1. [A5PLN9-2]
DR RefSeq; NP_001230666.1; NM_001243737.1. [A5PLN9-4]
DR RefSeq; NP_079217.2; NM_024941.3. [A5PLN9-1]
DR AlphaFoldDB; A5PLN9; -.
DR BioGRID; 123063; 94.
DR ComplexPortal; CPX-4749; TRAPP II complex, TRAPPC2 variant.
DR ComplexPortal; CPX-6902; TRAPP II complex, TRAPPC2B variant.
DR DIP; DIP-48284N; -.
DR IntAct; A5PLN9; 26.
DR MINT; A5PLN9; -.
DR STRING; 9606.ENSP00000409231; -.
DR GlyGen; A5PLN9; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; A5PLN9; -.
DR PhosphoSitePlus; A5PLN9; -.
DR BioMuta; TRAPPC13; -.
DR EPD; A5PLN9; -.
DR jPOST; A5PLN9; -.
DR MassIVE; A5PLN9; -.
DR MaxQB; A5PLN9; -.
DR PaxDb; A5PLN9; -.
DR PeptideAtlas; A5PLN9; -.
DR PRIDE; A5PLN9; -.
DR ProteomicsDB; 744; -. [A5PLN9-1]
DR ProteomicsDB; 745; -. [A5PLN9-2]
DR ProteomicsDB; 746; -. [A5PLN9-4]
DR ProteomicsDB; 747; -. [A5PLN9-5]
DR ProteomicsDB; 748; -. [A5PLN9-7]
DR Antibodypedia; 43978; 52 antibodies from 18 providers.
DR DNASU; 80006; -.
DR Ensembl; ENST00000231526.8; ENSP00000231526.4; ENSG00000113597.18. [A5PLN9-2]
DR Ensembl; ENST00000399438.8; ENSP00000382367.3; ENSG00000113597.18. [A5PLN9-1]
DR Ensembl; ENST00000438419.6; ENSP00000409231.2; ENSG00000113597.18. [A5PLN9-5]
DR Ensembl; ENST00000505553.5; ENSP00000423405.1; ENSG00000113597.18. [A5PLN9-4]
DR GeneID; 80006; -.
DR KEGG; hsa:80006; -.
DR MANE-Select; ENST00000399438.8; ENSP00000382367.3; NM_024941.4; NP_079217.2.
DR UCSC; uc003jtz.5; human. [A5PLN9-1]
DR CTD; 80006; -.
DR GeneCards; TRAPPC13; -.
DR HGNC; HGNC:25828; TRAPPC13.
DR HPA; ENSG00000113597; Low tissue specificity.
DR neXtProt; NX_A5PLN9; -.
DR OpenTargets; ENSG00000113597; -.
DR PharmGKB; PA162380280; -.
DR VEuPathDB; HostDB:ENSG00000113597; -.
DR eggNOG; KOG2625; Eukaryota.
DR GeneTree; ENSGT00390000015280; -.
DR HOGENOM; CLU_027041_0_0_1; -.
DR InParanoid; A5PLN9; -.
DR OMA; FKFQVVK; -.
DR OrthoDB; 1608721at2759; -.
DR PhylomeDB; A5PLN9; -.
DR TreeFam; TF314898; -.
DR PathwayCommons; A5PLN9; -.
DR Reactome; R-HSA-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR SignaLink; A5PLN9; -.
DR BioGRID-ORCS; 80006; 172 hits in 1087 CRISPR screens.
DR ChiTaRS; TRAPPC13; human.
DR GenomeRNAi; 80006; -.
DR Pharos; A5PLN9; Tdark.
DR PRO; PR:A5PLN9; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; A5PLN9; protein.
DR Bgee; ENSG00000113597; Expressed in buccal mucosa cell and 185 other tissues.
DR ExpressionAtlas; A5PLN9; baseline and differential.
DR Genevisible; A5PLN9; HS.
DR GO; GO:0005737; C:cytoplasm; IC:ComplexPortal.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:1990071; C:TRAPPII protein complex; IC:ComplexPortal.
DR GO; GO:1990072; C:TRAPPIII protein complex; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IC:ComplexPortal.
DR GO; GO:0006901; P:vesicle coating; IC:ComplexPortal.
DR GO; GO:0099022; P:vesicle tethering; IC:ComplexPortal.
DR InterPro; IPR010378; TRAPPC13.
DR PANTHER; PTHR13134; PTHR13134; 1.
DR Pfam; PF06159; DUF974; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..417
FT /note="Trafficking protein particle complex subunit 13"
FT /id="PRO_0000321547"
FT VAR_SEQ 183..188
FT /note="Missing (in isoform 2, isoform 3 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_038356"
FT VAR_SEQ 300..315
FT /note="APGYGDVRLSLEAIPD -> VSLEKTSLGFWCVKDR (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_038357"
FT VAR_SEQ 316..417
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_038358"
FT VAR_SEQ 332
FT /note="C -> CS (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.6"
FT /id="VSP_038359"
FT CONFLICT 177
FT /note="K -> R (in Ref. 6; AAY88966)"
FT /evidence="ECO:0000305"
FT CONFLICT 255
FT /note="L -> P (in Ref. 6; AAY88966)"
FT /evidence="ECO:0000305"
FT CONFLICT 403
FT /note="I -> V (in Ref. 5; AAI42995)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 417 AA; 46524 MW; 7E80D7B11511DC6E CRC64;
MEVNPPKQEH LLALKVMRLT KPTLFTNIPV TCEEKDLPGD LFNQLMRDDP STVNGAEVLM
LGEMLTLPQN FGNIFLGETF SSYISVHNDS NQVVKDILVK ADLQTSSQRL NLSASNAAVA
ELKPDCCIDD VIHHEVKEIG THILVCAVSY TTQAGEKMYF RKFFKFQVLK PLDVKTKFYN
AESDLSSVTD EVFLEAQIQN MTTSPMFMEK VSLEPSIMYN VTELNSVSQA GECVSTFGSR
AYLQPMDTRQ YLYCLKPKNE FAEKAGIIKG VTVIGKLDIV WKTNLGERGR LQTSQLQRMA
PGYGDVRLSL EAIPDTVNLE EPFHITCKIT NCSERTMDLV LEMCNTNSIH WCGISGRQLG
KLHPSSSLCL ALTLLSSVQG LQSISGLRLT DTFLKRTYEY DDIAQVCVVS SAIKVES
