TPC13_MOUSE
ID TPC13_MOUSE Reviewed; 417 AA.
AC Q3TIR1; Q3TQS3; Q3UE00; Q8BN93; Q8VDJ6; Q9CWW3; Q9CXV2;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Trafficking protein particle complex subunit 13;
GN Name=Trappc13;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J, and DBA/2J; TISSUE=Bone marrow, Egg, Eye, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Part of the multisubunit TRAPP (transport protein particle)
CC complex. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q3TIR1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3TIR1-2; Sequence=VSP_031800;
CC Name=3;
CC IsoId=Q3TIR1-3; Sequence=VSP_031799, VSP_031800;
CC -!- SIMILARITY: Belongs to the TRAPPC13 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB26869.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB29083.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC39168.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK010346; BAB26869.2; ALT_INIT; mRNA.
DR EMBL; AK013956; BAB29083.2; ALT_INIT; mRNA.
DR EMBL; AK084373; BAC39168.1; ALT_INIT; mRNA.
DR EMBL; AK149832; BAE29111.1; -; mRNA.
DR EMBL; AK163342; BAE37309.1; -; mRNA.
DR EMBL; AK167749; BAE39785.1; -; mRNA.
DR EMBL; BC021756; AAH21756.3; -; mRNA.
DR CCDS; CCDS49351.1; -. [Q3TIR1-3]
DR CCDS; CCDS49352.1; -. [Q3TIR1-1]
DR CCDS; CCDS49353.1; -. [Q3TIR1-2]
DR RefSeq; NP_001087228.1; NM_001093759.1. [Q3TIR1-1]
DR RefSeq; NP_001087229.1; NM_001093760.1. [Q3TIR1-3]
DR RefSeq; NP_080155.3; NM_025879.2. [Q3TIR1-2]
DR AlphaFoldDB; Q3TIR1; -.
DR ComplexPortal; CPX-4764; TRAPP II complex.
DR STRING; 10090.ENSMUSP00000022224; -.
DR iPTMnet; Q3TIR1; -.
DR PhosphoSitePlus; Q3TIR1; -.
DR EPD; Q3TIR1; -.
DR MaxQB; Q3TIR1; -.
DR PaxDb; Q3TIR1; -.
DR PRIDE; Q3TIR1; -.
DR ProteomicsDB; 258822; -. [Q3TIR1-1]
DR ProteomicsDB; 258823; -. [Q3TIR1-2]
DR ProteomicsDB; 258824; -. [Q3TIR1-3]
DR Antibodypedia; 43978; 52 antibodies from 18 providers.
DR DNASU; 66975; -.
DR Ensembl; ENSMUST00000022224; ENSMUSP00000022224; ENSMUSG00000021711. [Q3TIR1-2]
DR Ensembl; ENSMUST00000141557; ENSMUSP00000118316; ENSMUSG00000021711. [Q3TIR1-1]
DR Ensembl; ENSMUST00000144060; ENSMUSP00000114406; ENSMUSG00000021711. [Q3TIR1-3]
DR GeneID; 66975; -.
DR KEGG; mmu:66975; -.
DR UCSC; uc007rst.1; mouse. [Q3TIR1-1]
DR UCSC; uc007rsu.1; mouse. [Q3TIR1-2]
DR UCSC; uc007rsv.1; mouse. [Q3TIR1-3]
DR CTD; 80006; -.
DR MGI; MGI:1914225; Trappc13.
DR VEuPathDB; HostDB:ENSMUSG00000021711; -.
DR eggNOG; KOG2625; Eukaryota.
DR GeneTree; ENSGT00390000015280; -.
DR HOGENOM; CLU_027041_0_0_1; -.
DR InParanoid; Q3TIR1; -.
DR OMA; FKFQVVK; -.
DR OrthoDB; 1608721at2759; -.
DR PhylomeDB; Q3TIR1; -.
DR TreeFam; TF314898; -.
DR Reactome; R-MMU-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR BioGRID-ORCS; 66975; 8 hits in 71 CRISPR screens.
DR ChiTaRS; Trappc13; mouse.
DR PRO; PR:Q3TIR1; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q3TIR1; protein.
DR Bgee; ENSMUSG00000021711; Expressed in substantia nigra and 240 other tissues.
DR ExpressionAtlas; Q3TIR1; baseline and differential.
DR Genevisible; Q3TIR1; MM.
DR GO; GO:0005737; C:cytoplasm; IC:ComplexPortal.
DR GO; GO:1990071; C:TRAPPII protein complex; IC:ComplexPortal.
DR GO; GO:1990072; C:TRAPPIII protein complex; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IC:ComplexPortal.
DR GO; GO:0006901; P:vesicle coating; IC:ComplexPortal.
DR GO; GO:0099022; P:vesicle tethering; IC:ComplexPortal.
DR InterPro; IPR010378; TRAPPC13.
DR PANTHER; PTHR13134; PTHR13134; 1.
DR Pfam; PF06159; DUF974; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..417
FT /note="Trafficking protein particle complex subunit 13"
FT /id="PRO_0000321548"
FT VAR_SEQ 183..188
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031799"
FT VAR_SEQ 332
FT /note="C -> CS (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_031800"
FT CONFLICT 34
FT /note="E -> K (in Ref. 1; BAE29111)"
FT /evidence="ECO:0000305"
FT CONFLICT 291
FT /note="L -> V (in Ref. 1; BAB29083)"
FT /evidence="ECO:0000305"
FT CONFLICT 294
FT /note="S -> N (in Ref. 1; BAB29083)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 417 AA; 46477 MW; 6F3AD94C7494A174 CRC64;
MEVNPPKQEH LLALKVMRLT KPTLFTNIPV TCEEKDLPGD LFNQLMKDDP STVNGAEILM
LGEMLTLPQN FGNIFLGETF SSYISVHNDS NQVVKDILVK ADLQTSSQRL NLSASNAAVA
ELKPDCCIDD VIHHEVKEIG THILVCAVSY TTQGGEKMYF RKFFKFQVLK PLDVKTKFYN
AESDLSSVTD EVFLEAQIQN ITTSPMFMEK VSLEPSIMYN VTELNSVTQA GECISTFGSR
GYLQPMDTRQ YLYCLKPKKE FAEKAGIIKG VTVIGKLDIV WKTNLGERGR LQTSQLQRMA
PGYGDVRLSL EAIPDTVNLE EPFHITCKIT NCSERMMDLV LEMCNTNSIH WCGISGRQLG
KLHPSSSLCL ALTLLSSVQG LQSVSGLRLT DTFLKRTYEY DDIAQVCVVS AAVEVEA
