ID   BTUB_VIBVU              Reviewed;         606 AA.
AC   Q8DD41;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Vitamin B12 transporter BtuB {ECO:0000255|HAMAP-Rule:MF_01531};
DE   AltName: Full=Cobalamin receptor {ECO:0000255|HAMAP-Rule:MF_01531};
DE   AltName: Full=Outer membrane cobalamin translocator {ECO:0000255|HAMAP-Rule:MF_01531};
DE   Flags: Precursor;
GN   Name=btuB {ECO:0000255|HAMAP-Rule:MF_01531}; OrderedLocusNames=VV1_1173;
OS   Vibrio vulnificus (strain CMCP6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=216895;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CMCP6;
RA   Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.;
RT   "Complete genome sequence of Vibrio vulnificus CMCP6.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the active translocation of vitamin B12
CC       (cyanocobalamin) across the outer membrane to the periplasmic space. It
CC       derives its energy for transport by interacting with the trans-
CC       periplasmic membrane protein TonB. {ECO:0000255|HAMAP-Rule:MF_01531}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01531}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01531}.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family. BtuB (TC
CC       1.B.14.3.1) subfamily. {ECO:0000255|HAMAP-Rule:MF_01531}.
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DR   EMBL; AE016795; AAO09644.1; -; Genomic_DNA.
DR   RefSeq; WP_011079183.1; NC_004459.3.
DR   AlphaFoldDB; Q8DD41; -.
DR   SMR; Q8DD41; -.
DR   EnsemblBacteria; AAO09644; AAO09644; VV1_1173.
DR   KEGG; vvu:VV1_1173; -.
DR   HOGENOM; CLU_008287_18_0_6; -.
DR   OMA; SYELQWR; -.
DR   Proteomes; UP000002275; Chromosome 1.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:InterPro.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   HAMAP; MF_01531; BtuB; 1.
DR   InterPro; IPR010101; B12_transptr_BtuB.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR010916; TonB_box_CS.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010917; TonB_rcpt_CS.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   PROSITE; PS00430; TONB_DEPENDENT_REC_1; 1.
DR   PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Signal; TonB box;
KW   Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01531"
FT   CHAIN           23..606
FT                   /note="Vitamin B12 transporter BtuB"
FT                   /id="PRO_0000003493"
FT   MOTIF           29..36
FT                   /note="TonB box"
FT   MOTIF           589..606
FT                   /note="TonB C-terminal box"
SQ   SEQUENCE   606 AA;  66694 MW;  4945F57C1980474B CRC64;
     MQKSLLAIAM ASLLTPVSYL HAQEVQTNDT VVVTANRFEQ PLAEVIASTT VISKQEIEET
     QAKSLLDVLK RVPGIEVSQS GGRGHSASVF IRGFNSNQVL FLVDGVRINS AAGGISFNHI
     PVGIIERVEV IKGPGGALYG SDAIAGVINV ITTSSESSEG SVVSLGAGSD AQKEANFSTT
     RAFANGGVLK LAGGFEETEG FDIKDPETGL NYGYESQNLF ASYSQAFNDE FSGSASVRWY
     DSLTEYDSGG KNYGYSENLS ITADVQYSGS RLSSTLRANQ QAIENLDYSQ AEGKDNAGTV
     KKIALTNLQF LNQYLISEGI TIGAGADWRK EKLDDDALSY GYPDKLAGES RSTTGVYLST
     DLQLGDLQVT GSVRNDKHDT YDNYRTWSLG TRYQITESHS VRATFGTSFK APSYSDLTNN
     PDLKPEEAMS REIGYTGEFA LFTVDVAAYD NDVDNLIIWY EGSPWWYPEN VDATLKGLEI
     TGYFNTWFVH HTVVAEFKDH QDSGGNKLAK RADENYKWLM DASYENFDVN LTYTYTGERL
     GNPKEVSDPK NELPSVSLWD ASVGYWISPD LVVRARVDNL TNEKYQTTLS YNAPERRYFA
     NLTYQF