ID   TPC1_ASPOR              Reviewed;         318 AA.
AC   Q2UCW8;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Mitochondrial thiamine pyrophosphate carrier 1;
GN   Name=tpc1; ORFNames=AO090012000416;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Mitochondrial transporter that mediates uptake of thiamine
CC       pyrophosphate (ThPP) into mitochondria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; AP007161; BAE60597.1; -; Genomic_DNA.
DR   RefSeq; XP_001727436.1; XM_001727384.2.
DR   AlphaFoldDB; Q2UCW8; -.
DR   SMR; Q2UCW8; -.
DR   STRING; 510516.Q2UCW8; -.
DR   EnsemblFungi; BAE60597; BAE60597; AO090012000416.
DR   GeneID; 5987910; -.
DR   KEGG; aor:AO090012000416; -.
DR   VEuPathDB; FungiDB:AO090012000416; -.
DR   HOGENOM; CLU_015166_10_3_1; -.
DR   OMA; MYVCYGA; -.
DR   Proteomes; UP000006564; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..318
FT                   /note="Mitochondrial thiamine pyrophosphate carrier 1"
FT                   /id="PRO_0000320457"
FT   TRANSMEM        12..28
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..107
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..141
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..197
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..237
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        284..301
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          12..110
FT                   /note="Solcar 1"
FT   REPEAT          120..206
FT                   /note="Solcar 2"
FT   REPEAT          214..309
FT                   /note="Solcar 3"
SQ   SEQUENCE   318 AA;  34540 MW;  B0063F809A9861DB CRC64;
     MSAGGEHLKD EGTRRQVVLA GGIAGLVSRF CVAPLDVVKI RLQLQIHSLS DPTSHQNIKG
     PVYKGTLPTI RSIVREEGIT GLWKGNIPAE LMYVCYGAIQ FAAYRTTTQA LSQLDPYRLP
     PPAESFVAGA TAGGLATAST YPLDLLRTRF AAQGTERVYT SLYASVRDIA QNEGPKGFFR
     GCSAAVGQIV PYMGLFFATY ESLRPVMSGL HDLPFGSGDA AAGVVASVLA KTGVFPLDLV
     RKRLQVQGPT RSKYVHRNIP EYQGVYNTMA MIVRTQGMRG LYRGLTVSLF KAAPASAVTM
     WTYEKSLHYL RELEVASE