TPC1_ASPTN
ID TPC1_ASPTN Reviewed; 320 AA.
AC Q0CEN9;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Mitochondrial thiamine pyrophosphate carrier 1;
GN Name=tpc1; ORFNames=ATEG_07845;
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156;
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mitochondrial transporter that mediates uptake of thiamine
CC pyrophosphate (ThPP) into mitochondria. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; CH476604; EAU32107.1; -; Genomic_DNA.
DR RefSeq; XP_001216466.1; XM_001216466.1.
DR AlphaFoldDB; Q0CEN9; -.
DR SMR; Q0CEN9; -.
DR STRING; 341663.Q0CEN9; -.
DR EnsemblFungi; EAU32107; EAU32107; ATEG_07845.
DR GeneID; 4323017; -.
DR VEuPathDB; FungiDB:ATEG_07845; -.
DR eggNOG; KOG0752; Eukaryota.
DR HOGENOM; CLU_015166_10_3_1; -.
DR OMA; MYVCYGA; -.
DR OrthoDB; 1454699at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..320
FT /note="Mitochondrial thiamine pyrophosphate carrier 1"
FT /id="PRO_0000320458"
FT TRANSMEM 17..35
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..107
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..197
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..300
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 12..110
FT /note="Solcar 1"
FT REPEAT 119..205
FT /note="Solcar 2"
FT REPEAT 213..308
FT /note="Solcar 3"
SQ SEQUENCE 320 AA; 34635 MW; 69C5CC3B23B6BD58 CRC64;
MSAGGEHLKD EGTRRQVVLA GGIAGLVSRF CVAPLDVVKI RLQLQIHSLS DPSSHRNVSG
PIYKGTISTM RAIIREEGIT GLWKGNIPAE LMYVCYGGVQ FTTYRTTTQA LAQLPHRLPQ
PVESFVAGAS AGGLATAATY PLDLLRTRFA AQGTERVYTS LLASVRDIAR IEGPAGFFRG
CSAAVGQIVP YMGLFFATYE SLRPSLATVQ DLPFGSGDAL AGMIASVLAK TGVFPLDLVR
KRLQVQGPTR SRYIHRNIPE YRGVFNTLAL ILRTQGVRGL YRGLTVSLFK AAPASAVTMW
TYEETLRALQ AMEVAAQKDE
