ID   TPC1_CANAL              Reviewed;         301 AA.
AC   Q59Q36; A0A1D8PHQ2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Mitochondrial thiamine pyrophosphate carrier 1;
GN   Name=TPC1; OrderedLocusNames=CAALFM_C206520CA;
GN   ORFNames=CaO19.28, CaO19.7699;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Mitochondrial transporter that mediates uptake of thiamine
CC       pyrophosphate (ThPP) into mitochondria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; CP017624; AOW27655.1; -; Genomic_DNA.
DR   RefSeq; XP_711835.1; XM_706743.1.
DR   AlphaFoldDB; Q59Q36; -.
DR   SMR; Q59Q36; -.
DR   STRING; 237561.Q59Q36; -.
DR   GeneID; 3646571; -.
DR   KEGG; cal:CAALFM_C206520CA; -.
DR   CGD; CAL0000175641; orf19.7699.
DR   VEuPathDB; FungiDB:C2_06520C_A; -.
DR   eggNOG; KOG0752; Eukaryota.
DR   HOGENOM; CLU_015166_10_3_1; -.
DR   InParanoid; Q59Q36; -.
DR   OMA; MYVCYGA; -.
DR   OrthoDB; 1454699at2759; -.
DR   BRENDA; 2.7.6.2; 3474.
DR   PRO; PR:Q59Q36; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0015234; F:thiamine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0030974; P:thiamine pyrophosphate transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..301
FT                   /note="Mitochondrial thiamine pyrophosphate carrier 1"
FT                   /id="PRO_0000320460"
FT   TRANSMEM        20..38
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..227
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          15..102
FT                   /note="Solcar 1"
FT   REPEAT          115..200
FT                   /note="Solcar 2"
FT   REPEAT          206..293
FT                   /note="Solcar 3"
SQ   SEQUENCE   301 AA;  33132 MW;  06545080D319BF5C CRC64;
     MSTKREDHLR KGADVTPTEA LVAGSIAGAI SRAFTAPLDT IKIRLQLQPK GFKHRKSVVT
     IVKNLLENEG IIALWKGNVP AEILYILYGG VQFGSYSIIS KSVSKLENNY RINLSSANHS
     LIVGIGSGIV STLVTYPFDL LRTRLIANKN RGLLSMTGTI KDIIKLEGIR GIYAGIRPAM
     LSVSSTTGLM FWSYELAREL SNNYQRVPFI EAICGFIAGA TSKGITFPLD TLRKRCQMCS
     VVHGRPYTAS HIFVTILKNE GVFGLYKGFG ISVLKTAPTS AISLFMYEYS LSFIRKIRVI
     E