ID   TPC1_CANGA              Reviewed;         307 AA.
AC   Q6FTE5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Mitochondrial thiamine pyrophosphate carrier 1;
GN   Name=TPC1; OrderedLocusNames=CAGL0G03135g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Mitochondrial transporter that mediates uptake of thiamine
CC       pyrophosphate (ThPP) into mitochondria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; CR380953; CAG59426.1; -; Genomic_DNA.
DR   RefSeq; XP_446499.1; XM_446499.1.
DR   AlphaFoldDB; Q6FTE5; -.
DR   SMR; Q6FTE5; -.
DR   STRING; 5478.XP_446499.1; -.
DR   EnsemblFungi; CAG59426; CAG59426; CAGL0G03135g.
DR   GeneID; 2888325; -.
DR   KEGG; cgr:CAGL0G03135g; -.
DR   CGD; CAL0130807; CAGL0G03135g.
DR   VEuPathDB; FungiDB:CAGL0G03135g; -.
DR   eggNOG; KOG0752; Eukaryota.
DR   HOGENOM; CLU_015166_10_3_1; -.
DR   InParanoid; Q6FTE5; -.
DR   Proteomes; UP000002428; Chromosome G.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IEA:EnsemblFungi.
DR   GO; GO:0090422; F:thiamine pyrophosphate transmembrane transporter activity; IEA:EnsemblFungi.
DR   GO; GO:1990545; P:mitochondrial thiamine pyrophosphate transmembrane transport; IEA:EnsemblFungi.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..307
FT                   /note="Mitochondrial thiamine pyrophosphate carrier 1"
FT                   /id="PRO_0000320461"
FT   TRANSMEM        19..36
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..126
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..184
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..226
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..297
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          13..95
FT                   /note="Solcar 1"
FT   REPEAT          105..190
FT                   /note="Solcar 2"
FT   REPEAT          203..305
FT                   /note="Solcar 3"
SQ   SEQUENCE   307 AA;  34241 MW;  D18B483DAAAB715C CRC64;
     MNKKDHLRKD EEVSTTNSLV AGSLSGLFAR TCIAPLDTVK IKLQVTPHNK NANVLINILK
     REGIRGFWKG NVPGSIMYII YGGAQFGSYT YIGSFLRGGL DLNISPQLYS CLVGSLAGMT
     SSLASYPFDV LRTRFAANSQ GQLIKLRDEI MAIWSHEGLM GFFSGCGSSM INIGLNTAIM
     FGVYESIKIF TEERSKLSDR RDPFTLLNEL AGPISGFTSK LATFPLDTVR RRIQIRNSPN
     EERHDREFTK DIYKSYKNRR FLGVGISMVQ QEGPLSLYRG VTMSLIKSVP STAISLWSYE
     LFMNKLG