ID   BTUB_VIBVY              Reviewed;         613 AA.
AC   Q7MQ42;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Vitamin B12 transporter BtuB {ECO:0000255|HAMAP-Rule:MF_01531};
DE   AltName: Full=Cobalamin receptor {ECO:0000255|HAMAP-Rule:MF_01531};
DE   AltName: Full=Outer membrane cobalamin translocator {ECO:0000255|HAMAP-Rule:MF_01531};
DE   Flags: Precursor;
GN   Name=btuB {ECO:0000255|HAMAP-Rule:MF_01531}; OrderedLocusNames=VV0166;
OS   Vibrio vulnificus (strain YJ016).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=196600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJ016;
RX   PubMed=14656965; DOI=10.1101/gr.1295503;
RA   Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L.,
RA   Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P.,
RA   Lee C.-T., Hor L.-I., Tsai S.-F.;
RT   "Comparative genome analysis of Vibrio vulnificus, a marine pathogen.";
RL   Genome Res. 13:2577-2587(2003).
CC   -!- FUNCTION: Involved in the active translocation of vitamin B12
CC       (cyanocobalamin) across the outer membrane to the periplasmic space. It
CC       derives its energy for transport by interacting with the trans-
CC       periplasmic membrane protein TonB. {ECO:0000255|HAMAP-Rule:MF_01531}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01531}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01531}.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family. BtuB (TC
CC       1.B.14.3.1) subfamily. {ECO:0000255|HAMAP-Rule:MF_01531}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000037; BAC92930.1; -; Genomic_DNA.
DR   RefSeq; WP_011149173.1; NC_005139.1.
DR   AlphaFoldDB; Q7MQ42; -.
DR   SMR; Q7MQ42; -.
DR   STRING; 672.VV93_v1c01540; -.
DR   EnsemblBacteria; BAC92930; BAC92930; BAC92930.
DR   KEGG; vvy:VV0166; -.
DR   PATRIC; fig|196600.6.peg.209; -.
DR   eggNOG; COG4206; Bacteria.
DR   HOGENOM; CLU_008287_18_5_6; -.
DR   OMA; GHWAVNA; -.
DR   OrthoDB; 71288at2; -.
DR   Proteomes; UP000002675; Chromosome I.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:InterPro.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   HAMAP; MF_01531; BtuB; 1.
DR   InterPro; IPR010101; B12_transptr_BtuB.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR010916; TonB_box_CS.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   PROSITE; PS00430; TONB_DEPENDENT_REC_1; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Reference proteome;
KW   Signal; TonB box; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01531"
FT   CHAIN           23..613
FT                   /note="Vitamin B12 transporter BtuB"
FT                   /id="PRO_0000003494"
FT   MOTIF           29..36
FT                   /note="TonB box"
FT   MOTIF           591..613
FT                   /note="TonB C-terminal box"
SQ   SEQUENCE   613 AA;  66778 MW;  2948328A80941AB8 CRC64;
     MQKSLLAIAM ASLLTPISYL HAQEVQTNDT VVVTANRFEQ VESSVLASIS VVTKAEIEQL
     NVTTALDILK TLPGVEVNSQ GGKGQISSIF LRGTSSKHTL VLVDGVKINS ATAGGASLGL
     IPAFAIEQIE VVRGPRAAIY GSDAIGGVIH IKTIPANRQT KHDANLGYGN DDHSSLAWRS
     SGQLNDSTQA SFVFSDEKSD GYRVNEVAPS GDSHGYQSQT LFGSLRHEID DAWSVQFNGY
     QLSSDVEYAN QFSGVKNESN TDFYSIAGSL NFHKDNYSSQ LMVSRSDNES WDGVASGMVA
     KTALFSSRNS VSWLNHWVVV PALTLAAGVD YDQENARQGG ANATNYSKTE KDNKAAYVTA
     HFSKNIVTAE ASIRSDDDSA FGKHNTWNLG LGIAPSDYVE FIASTGTGFK APTFNDLYWP
     SSGNPNLKPE TSKSSEVGIR SYLPFVQIDI SAYRNEIEDM IDWAPTGPGG AWTPSNIDNA
     KIEGIEIEAL FETGVIEHRV SAEWKDPRDK SDDSFLIRRA RENFSWVSTY SADRFGFSAV
     ANYVGDRKDS TGKTMDAYTL LDISANYKMT EALTLGARVG NLFDKEYQTA HSSGGKYYVG
     EGRNWFATVN YRF