TPC1_CHAGB
ID TPC1_CHAGB Reviewed; 325 AA.
AC Q2HFL6;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Mitochondrial thiamine pyrophosphate carrier 1;
GN Name=TPC1; ORFNames=CHGG_00988;
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- FUNCTION: Mitochondrial transporter that mediates uptake of thiamine
CC pyrophosphate (ThPP) into mitochondria. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAQ92753.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CH408029; EAQ92753.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001220209.1; XM_001220208.1.
DR AlphaFoldDB; Q2HFL6; -.
DR SMR; Q2HFL6; -.
DR STRING; 38033.XP_001220209.1; -.
DR EnsemblFungi; EAQ92753; EAQ92753; CHGG_00988.
DR GeneID; 4386398; -.
DR eggNOG; KOG0752; Eukaryota.
DR HOGENOM; CLU_015166_10_3_1; -.
DR InParanoid; Q2HFL6; -.
DR OrthoDB; 1454699at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 2.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..325
FT /note="Mitochondrial thiamine pyrophosphate carrier 1"
FT /id="PRO_0000320462"
FT TRANSMEM 17..35
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..108
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..143
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..200
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..239
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..304
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 12..111
FT /note="Solcar 1"
FT REPEAT 122..209
FT /note="Solcar 2"
FT REPEAT 216..312
FT /note="Solcar 3"
SQ SEQUENCE 325 AA; 35755 MW; 5B63E70CA1E8295A CRC64;
MSLKGDRLKD EGSRLQVTAA GATAGLVARF VIAPLDVVKI RLQLQTHSLS DPLSHRDLHG
GPIYKGTLPT LRHILRSEGI TGLWKGNVPA ELLYVCYSAI QFTTYRTTTL LLHQTLGEGT
LPPSAESFVA GAIGGGTATA ATYPLDPAAH ALRRPGQRSR VCESVARRGP DWVVRRAPVG
FFGVWDRAWA QIIPYMSFFF ATYETLRPHL SELELPFSSS SAVARTMASV MAKSRTFPLD
LVRKRIQVQS PTRGRYVHKN IPEYYGGTVG ALRTILQREG LRGLYRGLTV SLLKAAPASA
VTMWTYERAL KFYSGVGEKG EEQRL
