ID   TPC1_COCIM              Reviewed;         319 AA.
AC   Q1E7P0; J3KJF0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Mitochondrial thiamine pyrophosphate carrier 1;
GN   Name=TPC1; ORFNames=CIMG_01423;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Mitochondrial transporter that mediates uptake of thiamine
CC       pyrophosphate (ThPP) into mitochondria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; GG704911; EAS36069.3; -; Genomic_DNA.
DR   RefSeq; XP_001247652.1; XM_001247651.2.
DR   AlphaFoldDB; Q1E7P0; -.
DR   SMR; Q1E7P0; -.
DR   STRING; 246410.Q1E7P0; -.
DR   PRIDE; Q1E7P0; -.
DR   EnsemblFungi; EAS36069; EAS36069; CIMG_01423.
DR   GeneID; 4567960; -.
DR   KEGG; cim:CIMG_01423; -.
DR   VEuPathDB; FungiDB:CIMG_01423; -.
DR   InParanoid; Q1E7P0; -.
DR   OMA; MYVCYGA; -.
DR   OrthoDB; 1454699at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..319
FT                   /note="Mitochondrial thiamine pyrophosphate carrier 1"
FT                   /id="PRO_0000320463"
FT   TRANSMEM        17..35
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..107
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..201
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..237
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        284..301
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          12..110
FT                   /note="Solcar 1"
FT   REPEAT          121..207
FT                   /note="Solcar 2"
FT   REPEAT          214..309
FT                   /note="Solcar 3"
SQ   SEQUENCE   319 AA;  34867 MW;  BFE85CAD05A0DCB0 CRC64;
     MSAGGEHLKD EGQRYQVVAA GAIAGMVSRF CVAPLDVVKI RLQLQIHSLS DPLSHKNIRG
     PVYKGTISTL KAIFREEGIT GLWKGNIPAE LLYIFYGAIQ FTTYRTVTQS LHTLPPPYRL
     PQPAESFVSG ATAGGIGTFT TYPFDLLRTR FAAQGNDKIY PSLLTAIRSI HAHEGSRGFF
     RGVSAAVAQI VPYMGLFFAT YESVRVPISS LHLPFGSGDA TAGVIASVIA KTGVFPLDLV
     RKRLQVQGPT RSRYIHQNIP EYNGVLSTMK MVLRDGGVRG LYRGLTVSLI KAAPASAVTM
     WTYERVLKIL KEINQEAIQ