ID   TPC1_MAGO7              Reviewed;         327 AA.
AC   A4RF23; G4NBT1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Mitochondrial thiamine pyrophosphate carrier 1;
GN   Name=TPC1; ORFNames=MGG_00489;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- FUNCTION: Mitochondrial transporter that mediates uptake of thiamine
CC       pyrophosphate (ThPP) into mitochondria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; CM001235; EHA48989.1; -; Genomic_DNA.
DR   RefSeq; XP_003718573.1; XM_003718525.1.
DR   AlphaFoldDB; A4RF23; -.
DR   SMR; A4RF23; -.
DR   STRING; 318829.MGG_00489T0; -.
DR   EnsemblFungi; MGG_00489T0; MGG_00489T0; MGG_00489.
DR   GeneID; 2674933; -.
DR   KEGG; mgr:MGG_00489; -.
DR   VEuPathDB; FungiDB:MGG_00489; -.
DR   eggNOG; KOG0752; Eukaryota.
DR   HOGENOM; CLU_015166_10_3_1; -.
DR   InParanoid; A4RF23; -.
DR   OMA; MYVCYGA; -.
DR   OrthoDB; 1454699at2759; -.
DR   Proteomes; UP000009058; Chromosome 5.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..327
FT                   /note="Mitochondrial thiamine pyrophosphate carrier 1"
FT                   /id="PRO_0000320468"
FT   TRANSMEM        16..36
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..111
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..245
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..309
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          13..114
FT                   /note="Solcar 1"
FT   REPEAT          126..214
FT                   /note="Solcar 2"
FT   REPEAT          222..317
FT                   /note="Solcar 3"
SQ   SEQUENCE   327 AA;  35767 MW;  2D7D30EF50922214 CRC64;
     MSAANTERLK DEGSKLQVVV AGATAGMIAR FVIAPLDVVK IRLQLQTHSL SDPLSQRAEL
     LRGGPVYKGT LSTMRHIARQ EGITGLWKGN VPAELLYITY SAVQFATYRS AAQLLHRVAG
     EDRQLPAAAE SFVAGAAAGV TSTTVTYPLD LLRTRFAAQG SGDDRVYQSL RRAVADIWRD
     EGYRGFFRGI GPAVGQTFPF MGIFFAAYES LRAPLADLKL PFWGGQLALA SMTASTLAKT
     AVFPLDLVRR RIQVQGPTRS KYVHKNIPEY KGTFSTISTI ARTEGFRGLY RGLTVSLIKS
     APASAVTMWT YERVLRALIT FQSGRQD