ID   TPC1_NEUCR              Reviewed;         333 AA.
AC   Q7S2H8;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Mitochondrial thiamine pyrophosphate carrier 1;
GN   Name=tpc-1; ORFNames=NCU07384;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Mitochondrial transporter that mediates uptake of thiamine
CC       pyrophosphate (ThPP) into mitochondria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM002236; EAA29641.1; -; Genomic_DNA.
DR   RefSeq; XP_958877.1; XM_953784.3.
DR   AlphaFoldDB; Q7S2H8; -.
DR   SMR; Q7S2H8; -.
DR   STRING; 5141.EFNCRP00000007314; -.
DR   PRIDE; Q7S2H8; -.
DR   EnsemblFungi; EAA29641; EAA29641; NCU07384.
DR   GeneID; 3875015; -.
DR   KEGG; ncr:NCU07384; -.
DR   VEuPathDB; FungiDB:NCU07384; -.
DR   HOGENOM; CLU_015166_10_3_1; -.
DR   InParanoid; Q7S2H8; -.
DR   OMA; MYVCYGA; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0015234; F:thiamine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0030974; P:thiamine pyrophosphate transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..333
FT                   /note="Mitochondrial thiamine pyrophosphate carrier 1"
FT                   /id="PRO_0000320470"
FT   TRANSMEM        17..35
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..112
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..209
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..238
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..310
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          12..115
FT                   /note="Solcar 1"
FT   REPEAT          129..215
FT                   /note="Solcar 2"
FT   REPEAT          222..318
FT                   /note="Solcar 3"
SQ   SEQUENCE   333 AA;  36097 MW;  91123E0FFB22CED6 CRC64;
     MSGKAERLKD EGSRLQVTAA GATAGLISRF VIAPLDVVKI RLQLQHHSLS DPLLHQRRAE
     IIGGGPVYKG TLPTIRHILR TEGLTGLWKG NIPAELLYVS YAAVQFTTYR SITQFLQAAF
     PKDQNKQLPP SVESFIAGAS AGGVATAVTY PLDLLRTRFA AQGVERVYPS LVQALKTIYA
     SEGVTGYFRG LGPGLAQIIP YMGTFFCVYE TLRPRLSKLE LPYSSGSAVA GVLASVMAKT
     GTFPLDLVRK RIQVQGPTRG MYVHKNIPVY DGGMVKTVAT IVRREGVRGL YRGLTVSLFK
     AAPASAVTMW TYERALKLYI RLGAAGPGRK EGV