ID   TPC1_PHANO              Reviewed;         321 AA.
AC   Q0UUH1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 3.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Mitochondrial thiamine pyrophosphate carrier 1;
GN   Name=TPC1; ORFNames=SNOG_04593;
OS   Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume
OS   blotch fungus) (Parastagonospora nodorum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Phaeosphaeriaceae;
OC   Parastagonospora.
OX   NCBI_TaxID=321614;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173;
RX   PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA   Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L.,
RA   Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E.,
RA   Torriani S.F.F., McDonald B.A., Oliver R.P.;
RT   "Dothideomycete-plant interactions illuminated by genome sequencing and EST
RT   analysis of the wheat pathogen Stagonospora nodorum.";
RL   Plant Cell 19:3347-3368(2007).
CC   -!- FUNCTION: Mitochondrial transporter that mediates uptake of thiamine
CC       pyrophosphate (ThPP) into mitochondria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAT88353.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH445330; EAT88353.2; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001795006.1; XM_001794954.1.
DR   AlphaFoldDB; Q0UUH1; -.
DR   SMR; Q0UUH1; -.
DR   STRING; 13684.SNOT_04593; -.
DR   GeneID; 5971874; -.
DR   KEGG; pno:SNOG_04593; -.
DR   eggNOG; KOG0752; Eukaryota.
DR   InParanoid; Q0UUH1; -.
DR   OMA; MYVCYGA; -.
DR   OrthoDB; 1454699at2759; -.
DR   Proteomes; UP000001055; Unassembled WGS sequence.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0015234; F:thiamine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0030974; P:thiamine pyrophosphate transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..321
FT                   /note="Mitochondrial thiamine pyrophosphate carrier 1"
FT                   /id="PRO_0000320471"
FT   TRANSMEM        17..38
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..107
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..199
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..231
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..303
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          12..110
FT                   /note="Solcar 1"
FT   REPEAT          121..207
FT                   /note="Solcar 2"
FT   REPEAT          216..311
FT                   /note="Solcar 3"
SQ   SEQUENCE   321 AA;  34541 MW;  45D0473DE1921E92 CRC64;
     MSEGVAQLKH EGSRQQVVVA GAAAGLVSRF VIAPLDVIKI RLQLQIHSLS EPTSYRGLNG
     PVYKGTLGTL KQILRDEGVT GLWKGNIPAE LLYLTYGSVQ FSAYTNISQM LDTIPAPYTL
     PSSANSFISG AGAGAAATTV TYPLDLLRTR FAAQGKDRVY TSIVASLKSI AQHEGPTGFF
     RGLGAGVSQI VPYMGLFFAS YESLKPVMAD SPLPLPLGSS DAVAGVVASV VSKTAVYPLD
     TTRKRLQVQG PNRARYVHRN IPTYSGVLMT LQHIWKHEGR RGMYRGLTVS LLKAAPASAV
     TMWTYERAMG IMVAFEKDGM E