TPC1_PICST
ID TPC1_PICST Reviewed; 305 AA.
AC A3LVX1;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Mitochondrial thiamine pyrophosphate carrier 1;
GN Name=TPC1; ORFNames=PICST_60941;
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- FUNCTION: Mitochondrial transporter that mediates uptake of thiamine
CC pyrophosphate (ThPP) into mitochondria. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; CP000499; ABN67190.2; -; Genomic_DNA.
DR RefSeq; XP_001385219.2; XM_001385182.1.
DR AlphaFoldDB; A3LVX1; -.
DR SMR; A3LVX1; -.
DR STRING; 4924.XP_001385219.2; -.
DR PRIDE; A3LVX1; -.
DR EnsemblFungi; ABN67190; ABN67190; PICST_60941.
DR GeneID; 4839711; -.
DR KEGG; pic:PICST_60941; -.
DR eggNOG; KOG0752; Eukaryota.
DR HOGENOM; CLU_015166_10_3_1; -.
DR InParanoid; A3LVX1; -.
DR OMA; MYVCYGA; -.
DR OrthoDB; 1454699at2759; -.
DR Proteomes; UP000002258; Chromosome 5.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..305
FT /note="Mitochondrial thiamine pyrophosphate carrier 1"
FT /id="PRO_0000320473"
FT TRANSMEM 16..32
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..100
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..193
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..229
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..287
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 16..103
FT /note="Solcar 1"
FT REPEAT 116..201
FT /note="Solcar 2"
FT REPEAT 206..295
FT /note="Solcar 3"
SQ SEQUENCE 305 AA; 33169 MW; D2525F9341FDCB6D CRC64;
MESRKREDHL RKGSEVSPYE SLLAGSISGA VARAVTAPLD TIKIRLQLQR SAFRSRVSVT
TVVKDLLKNE GAIALWKGNV PAEILYVLYG AAQFTTYSSI SRWLSHLSDT SGFNLPSSAH
SLVSGTGAGV VSTLVTYPFD LLRTRLAANS EKKLLSMSGT AREIISSEGF TGLFAGIKPA
MLSISTTTGL MFWSYELVRE TLGDRDIPFK EGICGFIAGA TSKGITFPLD TIRKRTQMYK
ILYNSAKRVG AFRLLADIVA NEGVLGLYKG FGISVLKTSP TSAVSLFVYE YSLAAIQRIN
RKTLD
