ID   TPC1_VANPO              Reviewed;         297 AA.
AC   A7TDX5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Mitochondrial thiamine pyrophosphate carrier 1;
GN   Name=TPC1; ORFNames=Kpol_1018p133;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Mitochondrial transporter that mediates uptake of thiamine
CC       pyrophosphate (ThPP) into mitochondria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; DS480378; EDO19595.1; -; Genomic_DNA.
DR   RefSeq; XP_001647453.1; XM_001647403.1.
DR   AlphaFoldDB; A7TDX5; -.
DR   SMR; A7TDX5; -.
DR   STRING; 436907.A7TDX5; -.
DR   EnsemblFungi; EDO19595; EDO19595; Kpol_1018p133.
DR   GeneID; 5547958; -.
DR   KEGG; vpo:Kpol_1018p133; -.
DR   eggNOG; KOG0752; Eukaryota.
DR   HOGENOM; CLU_015166_10_3_1; -.
DR   InParanoid; A7TDX5; -.
DR   OMA; MYVCYGA; -.
DR   OrthoDB; 1454699at2759; -.
DR   PhylomeDB; A7TDX5; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..297
FT                   /note="Mitochondrial thiamine pyrophosphate carrier 1"
FT                   /id="PRO_0000320475"
FT   TRANSMEM        19..36
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..91
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..128
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..187
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..287
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          13..94
FT                   /note="Solcar 1"
FT   REPEAT          102..195
FT                   /note="Solcar 2"
FT   REPEAT          196..295
FT                   /note="Solcar 3"
SQ   SEQUENCE   297 AA;  32264 MW;  18EA1E9C4C9C6189 CRC64;
     MREEDHLRKG EKSHVFESLV SGAIAGLAAR SAIAPLDTLK LRLQLGTDTL PHTLKSLIRH
     EGLLALWKGN LAGSIMYIIY GSVQFGTYSY TNAALLKVCD VPPTIHSTLA GAITGMASSL
     CSYPFDVLRT RLATTTTTTT TATTGRSGRG LYQHIERIYI REGLGGFFHG VATSMANVTV
     STAAMFGTYE GIRARWPETN AGTAGAISGV ISRTITFPLD TIRRRLQIRT SSELGQMTNN
     GYIGKHMQRS AITLCVQIVR DEGVKVLFRG IGLGLLKSVP NTAINLWVYE NLMRVLT