ID   TPC1_YARLI              Reviewed;         336 AA.
AC   Q6C107;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Mitochondrial thiamine pyrophosphate carrier 1;
GN   Name=TPC1; OrderedLocusNames=YALI0F20262g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Mitochondrial transporter that mediates uptake of thiamine
CC       pyrophosphate (ThPP) into mitochondria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382132; CAG78464.1; -; Genomic_DNA.
DR   RefSeq; XP_505655.1; XM_505655.1.
DR   AlphaFoldDB; Q6C107; -.
DR   SMR; Q6C107; -.
DR   STRING; 4952.CAG78464; -.
DR   EnsemblFungi; CAG78464; CAG78464; YALI0_F20262g.
DR   GeneID; 2907794; -.
DR   KEGG; yli:YALI0F20262g; -.
DR   VEuPathDB; FungiDB:YALI0_F20262g; -.
DR   HOGENOM; CLU_015166_10_3_1; -.
DR   InParanoid; Q6C107; -.
DR   OMA; MYVCYGA; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0015234; F:thiamine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0030974; P:thiamine pyrophosphate transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..336
FT                   /note="Mitochondrial thiamine pyrophosphate carrier 1"
FT                   /id="PRO_0000320476"
FT   TRANSMEM        17..37
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..244
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..315
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          11..98
FT                   /note="Solcar 1"
FT   REPEAT          112..202
FT                   /note="Solcar 2"
FT   REPEAT          221..323
FT                   /note="Solcar 3"
SQ   SEQUENCE   336 AA;  37139 MW;  C3A0C3107294294D CRC64;
     MSNHLSSDSD ISSTESMLCG GIAGMVSRFC IAPLDVVKIR LQLQKDGSRY YRGIFQTMQQ
     IVRDEGVTAL WKGNIPAELL YVFYGATQFV TYHHVNQVIN AYNETAEKWK ISSGAQSFIA
     GATAGAGATI ATYPFDLFRT LFAAQGAKNC NVKNYTSLFQ TFKLIYKTEG PLGFFRGVSS
     SIISIAPYMG LFFASYGRVK DSLDAFSNKH HDLLVSYNLP TKGWQEATAG LCAGTASKAL
     VFPLDTIRKR LQTQGRMDVS YKELSGKPGV QRLLDSYNPF VMARRIIVAE GCRGLYKGFL
     VSLIKSAPTS AITMYTFEKS LSILRWWKAQ GKSLEA