TPC3L_HUMAN
ID TPC3L_HUMAN Reviewed; 181 AA.
AC Q5T215; Q5T213; Q5T214;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Trafficking protein particle complex subunit 3-like protein;
DE Short=TRAPPC3-like protein;
DE AltName: Full=BET3-like protein;
GN Name=TRAPPC3L; Synonyms=BET3L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION IN TRAPP COMPLEX.
RX PubMed=21525244; DOI=10.1091/mbc.e10-11-0873;
RA Scrivens P.J., Noueihed B., Shahrzad N., Hul S., Brunet S., Sacher M.;
RT "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early
RT stage in ER-to-Golgi trafficking.";
RL Mol. Biol. Cell 22:2083-2093(2011).
CC -!- FUNCTION: May play a role in vesicular transport from endoplasmic
CC reticulum to Golgi. {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Component of the multisubunit TRAPP (transport
CC protein particle) complex, which includes at least TRAPPC2, TRAPPC2L,
CC TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10,
CC TRAPPC11 and TRAPPC12. {ECO:0000269|PubMed:21525244}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}.
CC Endoplasmic reticulum {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5T215-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5T215-2; Sequence=VSP_028222;
CC -!- SIMILARITY: Belongs to the TRAPP small subunits family. BET3 subfamily.
CC {ECO:0000305}.
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DR EMBL; AL445224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL121953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471051; EAW48227.1; -; Genomic_DNA.
DR EMBL; BC127757; AAI27758.1; -; mRNA.
DR EMBL; BC127758; AAI27759.1; -; mRNA.
DR CCDS; CCDS47468.1; -. [Q5T215-1]
DR RefSeq; NP_001132916.1; NM_001139444.2. [Q5T215-1]
DR AlphaFoldDB; Q5T215; -.
DR SMR; Q5T215; -.
DR BioGRID; 128706; 12.
DR CORUM; Q5T215; -.
DR IntAct; Q5T215; 1.
DR STRING; 9606.ENSP00000357591; -.
DR iPTMnet; Q5T215; -.
DR PhosphoSitePlus; Q5T215; -.
DR BioMuta; TRAPPC3L; -.
DR DMDM; 74744542; -.
DR jPOST; Q5T215; -.
DR MassIVE; Q5T215; -.
DR PaxDb; Q5T215; -.
DR PeptideAtlas; Q5T215; -.
DR PRIDE; Q5T215; -.
DR ProteomicsDB; 64304; -. [Q5T215-1]
DR DNASU; 100128327; -.
DR Ensembl; ENST00000356128.4; ENSP00000348445.4; ENSG00000173626.10. [Q5T215-2]
DR Ensembl; ENST00000368602.4; ENSP00000357591.3; ENSG00000173626.10. [Q5T215-1]
DR GeneID; 100128327; -.
DR KEGG; hsa:100128327; -.
DR MANE-Select; ENST00000368602.4; ENSP00000357591.3; NM_001139444.3; NP_001132916.1.
DR UCSC; uc003pwx.4; human. [Q5T215-1]
DR CTD; 100128327; -.
DR GeneCards; TRAPPC3L; -.
DR HGNC; HGNC:21090; TRAPPC3L.
DR HPA; ENSG00000173626; Tissue enhanced (brain).
DR MIM; 614137; gene.
DR neXtProt; NX_Q5T215; -.
DR OpenTargets; ENSG00000173626; -.
DR PharmGKB; PA134866254; -.
DR VEuPathDB; HostDB:ENSG00000173626; -.
DR eggNOG; KOG3330; Eukaryota.
DR GeneTree; ENSGT00390000003880; -.
DR HOGENOM; CLU_087110_2_0_1; -.
DR InParanoid; Q5T215; -.
DR OMA; HKINRDL; -.
DR OrthoDB; 1334804at2759; -.
DR PhylomeDB; Q5T215; -.
DR TreeFam; TF300091; -.
DR PathwayCommons; Q5T215; -.
DR SignaLink; Q5T215; -.
DR BioGRID-ORCS; 100128327; 17 hits in 1029 CRISPR screens.
DR ChiTaRS; TRAPPC3L; human.
DR GenomeRNAi; 100128327; -.
DR Pharos; Q5T215; Tdark.
DR PRO; PR:Q5T215; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5T215; protein.
DR Bgee; ENSG00000173626; Expressed in buccal mucosa cell and 108 other tissues.
DR ExpressionAtlas; Q5T215; baseline and differential.
DR Genevisible; Q5T215; HS.
DR GO; GO:0033106; C:cis-Golgi network membrane; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0030008; C:TRAPP complex; IDA:UniProtKB.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR CDD; cd14942; TRAPPC3_bet3; 1.
DR InterPro; IPR016721; Bet3.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR007194; TRAPP_component.
DR PANTHER; PTHR13048; PTHR13048; 1.
DR Pfam; PF04051; TRAPP; 1.
DR PIRSF; PIRSF018293; TRAPP_I_complex_Bet3; 1.
DR SUPFAM; SSF111126; SSF111126; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Endoplasmic reticulum; ER-Golgi transport;
KW Golgi apparatus; Lipoprotein; Palmitate; Reference proteome; Transport.
FT CHAIN 1..181
FT /note="Trafficking protein particle complex subunit 3-like
FT protein"
FT /id="PRO_0000305083"
FT LIPID 68
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..84
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028222"
SQ SEQUENCE 181 AA; 20566 MW; 3C2604CDF74B9CAE CRC64;
MSRPAHRRPE YHKINKDLFV LTYGALVAQL CKDYEKDEDV NQYLDKMGYG IGTRLVEDFL
ARSCVGRCHS YSEIIDIIAQ VAFKMYLGIT PSVTCNNSSK NEFSLILEKN PLVEFVEELP
AGRSSLCYCN LLCGIIRGAL EMVHLAADVT FLQDRLKGDS VTEIGITFLK KRDEKKYRGK
K
