TPC3L_MOUSE
ID TPC3L_MOUSE Reviewed; 181 AA.
AC Q4KL14;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Trafficking protein particle complex subunit 3-like protein;
DE Short=TRAPPC3-like protein;
DE AltName: Full=BET3-like protein;
GN Name=Trappc3l; Synonyms=Bet3l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Oocyte;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in vesicular transport from endoplasmic
CC reticulum to Golgi. {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Component of the multisubunit TRAPP (transport
CC protein particle) complex, which includes at least TRAPPC2, TRAPPC2L,
CC TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10,
CC TRAPPC11 and TRAPPC12 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}.
CC Endoplasmic reticulum {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TRAPP small subunits family. BET3 subfamily.
CC {ECO:0000305}.
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DR EMBL; BC099502; AAH99502.1; -; mRNA.
DR CCDS; CCDS48535.1; -.
DR RefSeq; NP_001156409.1; NM_001162937.1.
DR AlphaFoldDB; Q4KL14; -.
DR SMR; Q4KL14; -.
DR STRING; 10090.ENSMUSP00000093432; -.
DR PhosphoSitePlus; Q4KL14; -.
DR PaxDb; Q4KL14; -.
DR PRIDE; Q4KL14; -.
DR Ensembl; ENSMUST00000095758; ENSMUSP00000093432; ENSMUSG00000071340.
DR GeneID; 692132; -.
DR KEGG; mmu:692132; -.
DR UCSC; uc007euo.1; mouse.
DR CTD; 100128327; -.
DR MGI; MGI:3642034; Trappc3l.
DR VEuPathDB; HostDB:ENSMUSG00000071340; -.
DR eggNOG; KOG3330; Eukaryota.
DR GeneTree; ENSGT00390000003880; -.
DR HOGENOM; CLU_087110_0_1_1; -.
DR InParanoid; Q4KL14; -.
DR OMA; HKINRDL; -.
DR PhylomeDB; Q4KL14; -.
DR TreeFam; TF300091; -.
DR BioGRID-ORCS; 692132; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Trappc3l; mouse.
DR PRO; PR:Q4KL14; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q4KL14; protein.
DR Bgee; ENSMUSG00000071340; Expressed in primary oocyte and 6 other tissues.
DR ExpressionAtlas; Q4KL14; baseline and differential.
DR GO; GO:0033106; C:cis-Golgi network membrane; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0030008; C:TRAPP complex; ISO:MGI.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR CDD; cd14942; TRAPPC3_bet3; 1.
DR InterPro; IPR016721; Bet3.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR007194; TRAPP_component.
DR PANTHER; PTHR13048; PTHR13048; 1.
DR Pfam; PF04051; TRAPP; 1.
DR PIRSF; PIRSF018293; TRAPP_I_complex_Bet3; 1.
DR SUPFAM; SSF111126; SSF111126; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Lipoprotein;
KW Palmitate; Reference proteome; Transport.
FT CHAIN 1..181
FT /note="Trafficking protein particle complex subunit 3-like
FT protein"
FT /id="PRO_0000305084"
FT LIPID 68
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 181 AA; 20763 MW; 90F8EC31E26D9E00 CRC64;
MSRPAHKRPE YHKINKDLFV LTYGALVAQL CKDYEKDEDV NKYLDKMGYN IGTRLVEDFL
ARSCVRRCHS YSEIINIIAQ VAFKMYLGIT PSVTCHNSSR NEFSLILHKN PLAEFVEELP
AGRSALCYCN LLCGIIRGAL EMVHLAANVT FLQDRLKGDS VTEIGITFLK KLDEKKYRRK
K
