TPC6B_BOVIN
ID TPC6B_BOVIN Reviewed; 158 AA.
AC Q32L78;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Trafficking protein particle complex subunit 6B {ECO:0000250|UniProtKB:Q86SZ2};
DE Short=TRAPP complex subunit 6B;
GN Name=TRAPPC6B {ECO:0000250|UniProtKB:Q86SZ2};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of a transport protein particle (TRAPP) complex
CC that may function in specific stages of inter-organelle traffic (By
CC similarity). Specifically involved in the early development of neural
CC circuitry, likely by controlling the frequency and amplitude of
CC intracellular calcium transients implicated in the regulation of neuron
CC differentiation and survival (By similarity).
CC {ECO:0000250|UniProtKB:Q86SZ2}.
CC -!- SUBUNIT: Homodimer (By similarity). Part of a TRAPP complex.
CC Heterodimer with TRAPPC3 (By similarity). The heterodimer TRAPPC6B-
CC TRAPPC3 interacts with TRAPPC1 likely providing a core for TRAPP
CC complex formation (By similarity). {ECO:0000250|UniProtKB:Q86SZ2}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}.
CC Endoplasmic reticulum {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TRAPP small subunits family. BET3 subfamily.
CC {ECO:0000305}.
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DR EMBL; BC109723; AAI09724.1; -; mRNA.
DR RefSeq; NP_001033223.1; NM_001038134.1.
DR AlphaFoldDB; Q32L78; -.
DR SMR; Q32L78; -.
DR STRING; 9913.ENSBTAP00000019999; -.
DR PaxDb; Q32L78; -.
DR PRIDE; Q32L78; -.
DR Ensembl; ENSBTAT00000019999; ENSBTAP00000019999; ENSBTAG00000015023.
DR GeneID; 521470; -.
DR KEGG; bta:521470; -.
DR CTD; 122553; -.
DR VEuPathDB; HostDB:ENSBTAG00000015023; -.
DR VGNC; VGNC:36293; TRAPPC6B.
DR eggNOG; KOG3316; Eukaryota.
DR GeneTree; ENSGT00390000012948; -.
DR HOGENOM; CLU_076409_3_1_1; -.
DR InParanoid; Q32L78; -.
DR OMA; RTNHHGV; -.
DR OrthoDB; 1566836at2759; -.
DR TreeFam; TF313010; -.
DR Reactome; R-BTA-204005; COPII-mediated vesicle transport.
DR Reactome; R-BTA-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR Proteomes; UP000009136; Chromosome 21.
DR Bgee; ENSBTAG00000015023; Expressed in occipital lobe and 105 other tissues.
DR GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0030008; C:TRAPP complex; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0043087; P:regulation of GTPase activity; IEA:InterPro.
DR CDD; cd14944; TRAPPC6A_Trs33; 1.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR007194; TRAPP_component.
DR InterPro; IPR037992; TRAPPC6/Trs33.
DR PANTHER; PTHR12817; PTHR12817; 1.
DR Pfam; PF04051; TRAPP; 1.
DR SUPFAM; SSF111126; SSF111126; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Golgi apparatus; Neurogenesis; Reference proteome.
FT CHAIN 1..158
FT /note="Trafficking protein particle complex subunit 6B"
FT /id="PRO_0000244540"
SQ SEQUENCE 158 AA; 17983 MW; 5A8B0474548C304B CRC64;
MADEALFLLL HNEMVSGVYK SAEQGEVENG RCITKLENMG FRVGQGLIER FTKDTARFKD
ELDIMKFICK DFWTTVFKKQ IDNLRTNHQG IYVLQDNKFR LLTQMSAGKQ YLEHASKYLA
FTCGLIRGGL SNLGIKSIVT AEVSSMPACK FQVMIQKL
