ID   TPC6B_MOUSE             Reviewed;         158 AA.
AC   Q9D289;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Trafficking protein particle complex subunit 6B {ECO:0000250|UniProtKB:Q86SZ2};
DE            Short=TRAPP complex subunit 6B;
GN   Name=Trappc6b {ECO:0000250|UniProtKB:Q86SZ2, ECO:0000312|MGI:MGI:1925482};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Lung, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=16828797; DOI=10.1016/j.jmb.2006.06.012;
RA   Kummel D., Muller J.J., Roske Y., Henke N., Heinemann U.;
RT   "Structure of the Bet3-Tpc6B core of TRAPP: two Tpc6 paralogs form trimeric
RT   complexes with Bet3 and Mum2.";
RL   J. Mol. Biol. 361:22-32(2006).
CC   -!- FUNCTION: Component of a transport protein particle (TRAPP) complex
CC       that may function in specific stages of inter-organelle traffic (By
CC       similarity). Specifically involved in the early development of neural
CC       circuitry, likely by controlling the frequency and amplitude of
CC       intracellular calcium transients implicated in the regulation of neuron
CC       differentiation and survival (By similarity).
CC       {ECO:0000250|UniProtKB:Q86SZ2}.
CC   -!- SUBUNIT: Homodimer (By similarity). Part of a TRAPP complex.
CC       Heterodimer with TRAPPC3 (By similarity). The heterodimer TRAPPC6B-
CC       TRAPPC3 interacts with TRAPPC1 likely providing a core for TRAPP
CC       complex formation (By similarity). {ECO:0000250|UniProtKB:Q86SZ2}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}.
CC       Endoplasmic reticulum {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Widely expressed. Expressed in lung, heart, liver,
CC       spleen, brain and kidney. {ECO:0000269|PubMed:16828797}.
CC   -!- SIMILARITY: Belongs to the TRAPP small subunits family. BET3 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AK020026; BAB31972.1; -; mRNA.
DR   EMBL; AK089083; BAC40741.1; -; mRNA.
DR   EMBL; BC031464; AAH31464.1; -; mRNA.
DR   CCDS; CCDS25932.1; -.
DR   RefSeq; NP_001293146.1; NM_001306217.1.
DR   RefSeq; NP_001293147.1; NM_001306218.1.
DR   RefSeq; NP_084333.1; NM_030057.3.
DR   AlphaFoldDB; Q9D289; -.
DR   SMR; Q9D289; -.
DR   BioGRID; 219264; 5.
DR   ComplexPortal; CPX-4764; TRAPP II complex.
DR   IntAct; Q9D289; 2.
DR   STRING; 10090.ENSMUSP00000021380; -.
DR   iPTMnet; Q9D289; -.
DR   PhosphoSitePlus; Q9D289; -.
DR   EPD; Q9D289; -.
DR   MaxQB; Q9D289; -.
DR   PaxDb; Q9D289; -.
DR   PeptideAtlas; Q9D289; -.
DR   PRIDE; Q9D289; -.
DR   ProteomicsDB; 259164; -.
DR   Antibodypedia; 23365; 70 antibodies from 18 providers.
DR   DNASU; 78232; -.
DR   Ensembl; ENSMUST00000021380; ENSMUSP00000021380; ENSMUSG00000020993.
DR   GeneID; 78232; -.
DR   KEGG; mmu:78232; -.
DR   UCSC; uc007npy.1; mouse.
DR   CTD; 122553; -.
DR   MGI; MGI:1925482; Trappc6b.
DR   VEuPathDB; HostDB:ENSMUSG00000020993; -.
DR   eggNOG; KOG3316; Eukaryota.
DR   GeneTree; ENSGT00390000012948; -.
DR   HOGENOM; CLU_076409_3_1_1; -.
DR   InParanoid; Q9D289; -.
DR   OMA; RTNHHGV; -.
DR   OrthoDB; 1566836at2759; -.
DR   PhylomeDB; Q9D289; -.
DR   TreeFam; TF313010; -.
DR   Reactome; R-MMU-204005; COPII-mediated vesicle transport.
DR   Reactome; R-MMU-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   BioGRID-ORCS; 78232; 2 hits in 73 CRISPR screens.
DR   ChiTaRS; Trappc6b; mouse.
DR   PRO; PR:Q9D289; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; Q9D289; protein.
DR   Bgee; ENSMUSG00000020993; Expressed in retinal neural layer and 81 other tissues.
DR   ExpressionAtlas; Q9D289; baseline and differential.
DR   Genevisible; Q9D289; MM.
DR   GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IC:ComplexPortal.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR   GO; GO:0030008; C:TRAPP complex; IBA:GO_Central.
DR   GO; GO:1990071; C:TRAPPII protein complex; IC:ComplexPortal.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0043087; P:regulation of GTPase activity; IEA:InterPro.
DR   GO; GO:0006901; P:vesicle coating; IC:ComplexPortal.
DR   GO; GO:0099022; P:vesicle tethering; IC:ComplexPortal.
DR   CDD; cd14944; TRAPPC6A_Trs33; 1.
DR   InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR   InterPro; IPR007194; TRAPP_component.
DR   InterPro; IPR037992; TRAPPC6/Trs33.
DR   PANTHER; PTHR12817; PTHR12817; 1.
DR   Pfam; PF04051; TRAPP; 1.
DR   SUPFAM; SSF111126; SSF111126; 1.
PE   1: Evidence at protein level;
KW   Endoplasmic reticulum; Golgi apparatus; Neurogenesis; Reference proteome.
FT   CHAIN           1..158
FT                   /note="Trafficking protein particle complex subunit 6B"
FT                   /id="PRO_0000211588"
SQ   SEQUENCE   158 AA;  17936 MW;  DA7A047BC4807B9B CRC64;
     MADEALFLLL HNEMVSGVYK SAEQGEVENG RCVTKLESMG FRVGQGLIER FTKDTARFKD
     ELDIMKFICK DFWTTVFKKQ IDNLRTNHQG IYVLQDNKFR LLIQLSAGKQ YLEHASKYLA
     FTCGLIRGGL SNLGIKSIVT AEVSSMPACK FQVMIQKL