TPCD_RANDY
ID TPCD_RANDY Reviewed; 59 AA.
AC B3VZU5;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 23.
DE RecName: Full=Temporin-CDYd {ECO:0000303|PubMed:19539775, ECO:0000312|EMBL:ACF08005.1};
DE Flags: Precursor;
OS Rana dybowskii (Dybovsky's frog) (Korean brown frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana; Rana.
OX NCBI_TaxID=71582;
RN [1] {ECO:0000305, ECO:0000312|EMBL:ACF08005.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Skin {ECO:0000312|EMBL:ACF08005.1};
RX PubMed=19539775; DOI=10.1016/j.cbpb.2009.05.015;
RA Jin L.-L., Li Q., Song S.-S., Feng K., Zhang D.-B., Wang Q.-Y., Chen Y.-H.;
RT "Characterization of antimicrobial peptides isolated from the skin of the
RT Chinese frog, Rana dybowskii.";
RL Comp. Biochem. Physiol. 154B:174-178(2009).
CC -!- FUNCTION: Antimicrobial peptide. {ECO:0000250|UniProtKB:P79874}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P79874}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC {ECO:0000269|PubMed:19539775}.
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Temporin subfamily. {ECO:0000255}.
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DR EMBL; EU827805; ACF08005.1; -; mRNA.
DR AlphaFoldDB; B3VZU5; -.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR Pfam; PF03032; FSAP_sig_propep; 1.
PE 2: Evidence at transcript level;
KW Amphibian defense peptide; Antibiotic; Antimicrobial;
KW Cleavage on pair of basic residues; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255, ECO:0000312|EMBL:ACF08005.1"
FT PROPEP 23..42
FT /evidence="ECO:0000250|UniProtKB:P79874"
FT /id="PRO_0000391434"
FT PEPTIDE 45..59
FT /note="Temporin-CDYd"
FT /evidence="ECO:0000269|PubMed:19539775"
FT /id="PRO_5000381485"
SQ SEQUENCE 59 AA; 6620 MW; F943504C54538FB0 CRC64;
MFTLKKSMLL LLFLGTISLT LCEEERDANE EEENGGEVKE EEKRFIGPLI SALASLFKG