TPCR1_PONAB
ID TPCR1_PONAB Reviewed; 1165 AA.
AC Q5R5Y0;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Tectonin beta-propeller repeat-containing protein 1;
GN Name=TECPR1;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Tethering factor involved in autophagy. Involved in
CC autophagosome maturation by promoting the autophagosome fusion with
CC lysosomes: acts by associating with both the ATG5-ATG12 conjugate and
CC phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of
CC autophagosomes. Also involved in selective autophagy against bacterial
CC pathogens, by being required for phagophore/preautophagosomal structure
CC biogenesis and maturation (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ATG5; the interaction is direct. Interacts with
CC WIPI2. Interacts with the ATG5-ATG12 conjugate, the interaction is
CC however mutually exclusive with ATG16, since it does not interact with
CC ATG12-ATG5-ATG16 complex.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane
CC {ECO:0000250}. Lysosome membrane {ECO:0000250}. Note=Localizes to
CC Lysosome membranes, and binds PtdIns(3)P at the surface of
CC autophagosome. Localizes to autolysosomes, a vesicle formed by the
CC fusion between autophagosomes and lysosomes (By similarity).
CC {ECO:0000250}.
CC -!- DOMAIN: The PH domain mediates the binding to phosphatidylinositol-3-
CC phosphate (PtdIns(3)P). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TECPR1 family. {ECO:0000305}.
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DR EMBL; CR860721; CAH92836.1; -; mRNA.
DR RefSeq; NP_001126656.1; NM_001133184.1.
DR AlphaFoldDB; Q5R5Y0; -.
DR SMR; Q5R5Y0; -.
DR STRING; 9601.ENSPPYP00000019454; -.
DR GeneID; 100173656; -.
DR KEGG; pon:100173656; -.
DR CTD; 25851; -.
DR eggNOG; KOG3669; Eukaryota.
DR InParanoid; Q5R5Y0; -.
DR OrthoDB; 119234at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0000421; C:autophagosome membrane; ISS:UniProtKB.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB.
DR GO; GO:0097352; P:autophagosome maturation; ISS:UniProtKB.
DR GO; GO:0006914; P:autophagy; ISS:UniProtKB.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR006624; Beta-propeller_rpt_TECPR.
DR InterPro; IPR010482; Peroxin.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR InterPro; IPR011993; PH-like_dom_sf.
DR Pfam; PF06462; Hyd_WA; 2.
DR Pfam; PF06398; Pex24p; 2.
DR Pfam; PF19193; Tectonin; 2.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM00706; TECPR; 11.
PE 2: Evidence at transcript level;
KW Autophagy; Cytoplasmic vesicle; Lipid-binding; Lysosome; Membrane;
KW Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..1165
FT /note="Tectonin beta-propeller repeat-containing protein 1"
FT /id="PRO_0000337062"
FT REPEAT 209..240
FT /note="TECPR 1"
FT REPEAT 254..285
FT /note="TECPR 2"
FT REPEAT 301..332
FT /note="TECPR 3"
FT REPEAT 344..376
FT /note="TECPR 4"
FT DOMAIN 611..717
FT /note="PH"
FT REPEAT 729..756
FT /note="TECPR 5"
FT REPEAT 953..984
FT /note="TECPR 6"
FT REPEAT 998..1029
FT /note="TECPR 7"
FT REPEAT 1044..1075
FT /note="TECPR 8"
FT REPEAT 1087..1127
FT /note="TECPR 9"
FT REGION 404..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1140..1165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1140..1154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 938
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z6L1"
FT MOD_RES 949
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z6L1"
SQ SEQUENCE 1165 AA; 129774 MW; 661B00101888DF09 CRC64;
MPNSVLWAVD LFGRVYTLST AGQYWELCKD SQLEFKRVSA TTQCCWGIAC DNQVYVYVCA
SDVPIRRREE AYENQRWNPV GGFCEKLLLS DRWAWSDVSG LQHRPLDGVA LPSPHWEWES
DWYVDENFGG EPTEKGGWTY AIDFPATYTK EKKWNSCVRR RKWIRYRRYK SRDIWAKIPS
KDDPKELPDP FNDLSVGGWE IAEEPVGRLS VWAVSLQGKV WYREDVSHSN PEGSSWSLLD
TPGEVVQISC GPHDLLWATL WEGQALVREG INRSNPKGSS WSIVEPPGSD NGIMHVSVGV
SVVWAVTKDW KVWFRRGINS HNPCGTSWIE MVGEMTMVNV GMNDQVWGIG CEDRAVYFRQ
GVTPSELSGK TWKAIVAARE CDRSHSGSSS SLLSAGCFFG DEVRGSGESA PSDTDASSEV
ERPGPGQTLP AEPLDDSKNA MENSASGPGA GRTTEDTVED ACPAEGSREA RPNTHPGPAT
TPAELPWTNI DLKEPKKVPS HSAAGFPETT SLSSLGLFPL GLEEPYGVDD HPLRAWVSGG
GCMVEACAVP RWFTVQAGLS SSVHMLSLSI TPAQTAAWRK QIFQQLTERT KRELENFRHY
EQAVEQSVWV KTGALQWWCD WKPHKWVDVR VALEQFTGHD GARDSILFIY YVVHEEKKYI
HIFLNEVVAL VPVLNETKHS FALYTPERTR QRWPVRLAAA TEQDMNDWLA LLSLSCCESR
KVQGRPSPQA IWSITCKGDI FVSEPSPDLE AHEHPLPCDQ MFWRQMGGHL RMVEANSRGV
VWGIGYDHTA WVYTGGYGGG CFQGLASSTS NIYMQSDVKC VHIYENQRWN PVTGYTSRGL
PTDRYMWSDA SGLQECTKAG TKPPSLQWAW VSDWFVDFSV PGGTDQEGWQ YASDFPASYH
GSKTMKDFVR RRCRARKCKL VTSGPWLEVP PIALRDVSII PESPGAEGSG HSIALWAVSD
KGDVLCRLGV SELNPAGSSW LHVGTDQPFT SISIGACYQV WAVARDGSTF YRGSVYPSQP
AGDCWYHIPS PPRQRLKQVS VGQTSVYALD ENGNLWYRQG ITPSYPQGSS WEHVSNNVCR
VSVGPLDQVW VIADKVQGSH SLSRGTVCHR TGVQPHEPKG HGWDYGIGGG WDHISVRANA
TRAPRSSSQE QEPSAPPEAH DPVCC
