ID   TPC_BOVIN               Reviewed;         318 AA.
AC   Q29RM1;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Mitochondrial thiamine pyrophosphate carrier;
DE   AltName: Full=Solute carrier family 25 member 19;
GN   Name=SLC25A19; Synonyms=DNC;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial transporter mediating uptake of thiamine
CC       pyrophosphate (ThPP) into mitochondria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- MISCELLANEOUS: The transmembrane helices are not perpendicular to the
CC       plane of the membrane, but cross the membrane at an angle. Odd-numbered
CC       transmembrane helices exhibit a sharp kink, due to the presence of a
CC       conserved proline residue (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC114115; AAI14116.1; -; mRNA.
DR   RefSeq; NP_001039352.1; NM_001045887.1.
DR   RefSeq; XP_005221206.1; XM_005221149.3.
DR   RefSeq; XP_010814811.1; XM_010816509.2.
DR   RefSeq; XP_015314442.1; XM_015458956.1.
DR   RefSeq; XP_015314443.1; XM_015458957.1.
DR   AlphaFoldDB; Q29RM1; -.
DR   SMR; Q29RM1; -.
DR   STRING; 9913.ENSBTAP00000000237; -.
DR   PaxDb; Q29RM1; -.
DR   PRIDE; Q29RM1; -.
DR   Ensembl; ENSBTAT00000000237; ENSBTAP00000000237; ENSBTAG00000000202.
DR   GeneID; 504418; -.
DR   KEGG; bta:504418; -.
DR   CTD; 60386; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000202; -.
DR   VGNC; VGNC:34747; SLC25A19.
DR   eggNOG; KOG0752; Eukaryota.
DR   GeneTree; ENSGT00550000074902; -.
DR   HOGENOM; CLU_015166_10_3_1; -.
DR   InParanoid; Q29RM1; -.
DR   OMA; MYVCYGA; -.
DR   OrthoDB; 1454699at2759; -.
DR   TreeFam; TF313047; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000000202; Expressed in monocyte and 105 other tissues.
DR   ExpressionAtlas; Q29RM1; baseline and differential.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0015234; F:thiamine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0030974; P:thiamine pyrophosphate transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..318
FT                   /note="Mitochondrial thiamine pyrophosphate carrier"
FT                   /id="PRO_0000263627"
FT   TRANSMEM        19..39
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          13..106
FT                   /note="Solcar 1"
FT   REPEAT          116..202
FT                   /note="Solcar 2"
FT   REPEAT          214..309
FT                   /note="Solcar 3"
FT   MOTIF           241..246
FT                   /note="Substrate recognition"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         51
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HC21"
SQ   SEQUENCE   318 AA;  35112 MW;  A9E4A57A27361586 CRC64;
     MVGYDPKADD RDISNVEVAV AGSVSGLVTR VLISPLDVIK IRFQLQIERL SRSDPNAKYH
     GILQAGRQIL QEEGPTAFWK GHIPAQLLSI GYGAVQFLSF EALTELVHRA SVRDARDFSV
     HFLCGGLSAC VATLAVHPVD VLRTRFAAQG EPRVYKTLRD AVVTMYRTEG PLVFYKGLNP
     TLIAIFPYAG FQFSIYSSLK RAYEWALPAE GKKNGNFKNL LCGSGAGVIS KTLTYPLDLF
     KKRLQVGGFE QARASFGQVR SYKGLLDCAG QVLREEGAQG CFKGLSPSLL KAALSTGLVF
     FWYELFCNFF HHMRKADS