TPC_DICDI
ID TPC_DICDI Reviewed; 323 AA.
AC Q54VS7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Probable mitochondrial thiamine pyrophosphate carrier;
DE AltName: Full=Mitochondrial substrate carrier family protein K;
DE AltName: Full=Solute carrier family 25 member 19 homolog;
GN Name=mcfK; Synonyms=slc25a19; ORFNames=DDB_G0280161;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP REVIEW.
RX PubMed=17442478; DOI=10.1016/j.biochi.2007.03.004;
RA Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G.,
RA Klein G.;
RT "Mitochondrial carrier family: repertoire and peculiarities of the cellular
RT slime mould Dictyostelium discoideum.";
RL Biochimie 89:1058-1069(2007).
CC -!- FUNCTION: Mitochondrial transporter mediating uptake of thiamine
CC pyrophosphate (ThPP) into mitochondria. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000035; EAL67307.1; -; Genomic_DNA.
DR RefSeq; XP_641278.1; XM_636186.1.
DR AlphaFoldDB; Q54VS7; -.
DR SMR; Q54VS7; -.
DR PaxDb; Q54VS7; -.
DR EnsemblProtists; EAL67307; EAL67307; DDB_G0280161.
DR GeneID; 8622410; -.
DR KEGG; ddi:DDB_G0280161; -.
DR dictyBase; DDB_G0280161; mcfK.
DR eggNOG; KOG0752; Eukaryota.
DR HOGENOM; CLU_015166_10_3_1; -.
DR InParanoid; Q54VS7; -.
DR OMA; MYVCYGA; -.
DR PhylomeDB; Q54VS7; -.
DR Reactome; R-DDI-196819; Vitamin B1 (thiamin) metabolism.
DR PRO; PR:Q54VS7; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0015234; F:thiamine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0030974; P:thiamine pyrophosphate transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..323
FT /note="Probable mitochondrial thiamine pyrophosphate
FT carrier"
FT /id="PRO_0000328691"
FT TRANSMEM 15..35
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 13..115
FT /note="Solcar 1"
FT REPEAT 136..220
FT /note="Solcar 2"
FT REPEAT 233..318
FT /note="Solcar 3"
SQ SEQUENCE 323 AA; 36272 MW; 73521523B0FA8461 CRC64;
MIITTSNDED KKTNVFVELA AGSFSGALTR FIVAPLDVVK IRLQLQRTQL NNNSNNNNKI
IGKENVNYRG IINTMSKVIR EEGIRSLWKG NFSAELLWVT YAAIQFSTYN EIIGILDPEY
RKHQQRTDKD KPNYKPSSSI TMIGGASAGI LSTIVSYPFD IIRTNIVNNH NKTNFKQTFK
TIIARNGGYS NLFSGINSSL FQIVPQMGFQ FTFYETFKFI SNKYTSSVNN NNNNPLNQFT
CGLLSGAISK FLVLPFDVVK KRLQVNEKVG YGMKSCFRDL YFNEGGVKAF FKGGTPGIVK
AGLAAALSFT FFEQSKRILL NKQ
