ID   TPC_MACFA               Reviewed;         320 AA.
AC   Q5IS35;
DT   24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Mitochondrial thiamine pyrophosphate carrier;
DE   AltName: Full=Solute carrier family 25 member 19;
GN   Name=SLC25A19;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15620360; DOI=10.1016/j.cell.2004.11.040;
RA   Dorus S., Vallender E.J., Evans P.D., Anderson J.R., Gilbert S.L.,
RA   Mahowald M., Wyckoff G.J., Malcom C.M., Lahn B.T.;
RT   "Accelerated evolution of nervous system genes in the origin of Homo
RT   sapiens.";
RL   Cell 119:1027-1040(2004).
CC   -!- FUNCTION: Mitochondrial transporter mediating uptake of thiamine
CC       pyrophosphate (ThPP) into mitochondria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- MISCELLANEOUS: The transmembrane helices are not perpendicular to the
CC       plane of the membrane, but cross the membrane at an angle. Odd-numbered
CC       transmembrane helices exhibit a sharp kink, due to the presence of a
CC       conserved proline residue (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; AY665293; AAV74331.1; -; mRNA.
DR   RefSeq; NP_001306520.1; NM_001319591.1.
DR   RefSeq; XP_005584981.2; XM_005584924.2.
DR   RefSeq; XP_005584982.2; XM_005584925.2.
DR   RefSeq; XP_005584983.2; XM_005584926.2.
DR   RefSeq; XP_015294319.1; XM_015438833.1.
DR   RefSeq; XP_015294320.1; XM_015438834.1.
DR   AlphaFoldDB; Q5IS35; -.
DR   SMR; Q5IS35; -.
DR   STRING; 9541.XP_005584981.1; -.
DR   PRIDE; Q5IS35; -.
DR   GeneID; 102117428; -.
DR   CTD; 60386; -.
DR   eggNOG; KOG0752; Eukaryota.
DR   OrthoDB; 1454699at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..320
FT                   /note="Mitochondrial thiamine pyrophosphate carrier"
FT                   /id="PRO_0000090612"
FT   TRANSMEM        19..39
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          13..106
FT                   /note="Solcar 1"
FT   REPEAT          116..202
FT                   /note="Solcar 2"
FT   REPEAT          214..309
FT                   /note="Solcar 3"
FT   MOTIF           241..246
FT                   /note="Substrate recognition"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         51
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HC21"
SQ   SEQUENCE   320 AA;  35724 MW;  88CFEE49D1B0A3C0 CRC64;
     MVGYDPKPDG RNNTKLQVAV AGSVSGLVTR ALISPFDVIK IRFQLQHERL SRRDPNAKYH
     GIFQASRQIL QEEGLTAFWK GHIPAQILSI GYGAVQFLSF EMLTELVHRG SVYDAREFSV
     HFVCGGLAAC TATLTVHPVD VLRTRFAAQG EPKVYNTLRH AVGTMYRSEG PQVFYKGLAP
     TLIAIFPYAG LQFSCYSSLK HLYKWAMPAE GKKNENLQNL LCGSGAGVIS KTLTYPLDLF
     KKRLQVGGFE HARAAFGQVR RYKGLMDCAK QVLQKEGALG FFKGLSPSLL KAALSTGFMF
     FWYEFFCNVF HCMNRTASQR