TPC_MOUSE
ID TPC_MOUSE Reviewed; 318 AA.
AC Q9DAM5; A2A9V6; Q3T9C4;
DT 11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Mitochondrial thiamine pyrophosphate carrier;
DE AltName: Full=Solute carrier family 25 member 19;
GN Name=Slc25a19;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Spleen, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, and Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Mitochondrial transporter mediating uptake of thiamine
CC pyrophosphate (ThPP) into mitochondria. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- MISCELLANEOUS: The transmembrane helices are not perpendicular to the
CC plane of the membrane, but cross the membrane at an angle. Odd-numbered
CC transmembrane helices exhibit a sharp kink, due to the presence of a
CC conserved proline residue (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AK005710; BAB24199.1; -; mRNA.
DR EMBL; AK172622; BAE43100.1; -; mRNA.
DR EMBL; AL645470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC018167; AAH18167.1; -; mRNA.
DR CCDS; CCDS25644.1; -.
DR RefSeq; NP_001239313.1; NM_001252384.1.
DR RefSeq; NP_001239324.1; NM_001252395.1.
DR RefSeq; NP_080347.1; NM_026071.3.
DR RefSeq; XP_006534042.1; XM_006533979.3.
DR RefSeq; XP_017170203.1; XM_017314714.1.
DR AlphaFoldDB; Q9DAM5; -.
DR SMR; Q9DAM5; -.
DR BioGRID; 212072; 1.
DR STRING; 10090.ENSMUSP00000021089; -.
DR PhosphoSitePlus; Q9DAM5; -.
DR EPD; Q9DAM5; -.
DR MaxQB; Q9DAM5; -.
DR PaxDb; Q9DAM5; -.
DR PRIDE; Q9DAM5; -.
DR ProteomicsDB; 258828; -.
DR Antibodypedia; 46024; 104 antibodies from 18 providers.
DR DNASU; 67283; -.
DR Ensembl; ENSMUST00000021089; ENSMUSP00000021089; ENSMUSG00000020744.
DR Ensembl; ENSMUST00000178003; ENSMUSP00000137534; ENSMUSG00000020744.
DR GeneID; 67283; -.
DR KEGG; mmu:67283; -.
DR UCSC; uc007mig.2; mouse.
DR CTD; 60386; -.
DR MGI; MGI:1914533; Slc25a19.
DR VEuPathDB; HostDB:ENSMUSG00000020744; -.
DR eggNOG; KOG0752; Eukaryota.
DR GeneTree; ENSGT00550000074902; -.
DR HOGENOM; CLU_015166_10_3_1; -.
DR InParanoid; Q9DAM5; -.
DR OMA; MYVCYGA; -.
DR OrthoDB; 1454699at2759; -.
DR PhylomeDB; Q9DAM5; -.
DR TreeFam; TF313047; -.
DR Reactome; R-MMU-196819; Vitamin B1 (thiamin) metabolism.
DR BioGRID-ORCS; 67283; 18 hits in 73 CRISPR screens.
DR ChiTaRS; Slc25a19; mouse.
DR PRO; PR:Q9DAM5; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9DAM5; protein.
DR Bgee; ENSMUSG00000020744; Expressed in retinal neural layer and 227 other tissues.
DR ExpressionAtlas; Q9DAM5; baseline and differential.
DR Genevisible; Q9DAM5; MM.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0015234; F:thiamine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0030974; P:thiamine pyrophosphate transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..318
FT /note="Mitochondrial thiamine pyrophosphate carrier"
FT /id="PRO_0000090613"
FT TRANSMEM 19..39
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 13..106
FT /note="Solcar 1"
FT REPEAT 116..202
FT /note="Solcar 2"
FT REPEAT 214..309
FT /note="Solcar 3"
FT MOTIF 241..246
FT /note="Substrate recognition"
FT /evidence="ECO:0000250"
SQ SEQUENCE 318 AA; 35618 MW; 006DC5B11FA12A5B CRC64;
MVGYDAKADV RSNSKLEVAV AGSVSGFVTR ALISPLDVIK IRFQLQIERL CPSDPNAKYH
GIFQAAKQIL QEEGPRAFWK GHVPAQILSI GYGAVQFLAF EELTELLYQA NLYQTHQFSA
HFVCGGLSAG TATLTVHPVD VLRTRLAAQG EPKIYNNLRE AIRTMYKTEG PFVFYKGLTP
TVIAIFPYAG LQFSCYRSLK RAYDWLIPPD GKQTGNLKNL LCGCGSGVIS KTFTYPLDLI
KKRLQVGGFE HARSAFGQVR SYRGLLDLTQ QVLQEEGTRG FFKGLSPSLM KAALSTGFMF
FWYELFCNLF HCIRREDR
