TPC_PONAB
ID TPC_PONAB Reviewed; 320 AA.
AC Q5NVC1;
DT 24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Mitochondrial thiamine pyrophosphate carrier;
DE AltName: Full=Solute carrier family 25 member 19;
GN Name=SLC25A19;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mitochondrial transporter mediating uptake of thiamine
CC pyrophosphate (ThPP) into mitochondria. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- MISCELLANEOUS: The transmembrane helices are not perpendicular to the
CC plane of the membrane, but cross the membrane at an angle. Odd-numbered
CC transmembrane helices exhibit a sharp kink, due to the presence of a
CC conserved proline residue (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; CR926117; CAI29742.1; -; mRNA.
DR RefSeq; NP_001127123.1; NM_001133651.1.
DR AlphaFoldDB; Q5NVC1; -.
DR SMR; Q5NVC1; -.
DR Ensembl; ENSPPYT00000035360; ENSPPYP00000038003; ENSPPYG00000008625.
DR GeneID; 100174169; -.
DR KEGG; pon:100174169; -.
DR CTD; 60386; -.
DR GeneTree; ENSGT00550000074902; -.
DR InParanoid; Q5NVC1; -.
DR OrthoDB; 1454699at2759; -.
DR Proteomes; UP000001595; Chromosome 17.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..320
FT /note="Mitochondrial thiamine pyrophosphate carrier"
FT /id="PRO_0000090614"
FT TRANSMEM 19..39
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 13..106
FT /note="Solcar 1"
FT REPEAT 116..202
FT /note="Solcar 2"
FT REPEAT 214..309
FT /note="Solcar 3"
FT MOTIF 241..246
FT /note="Substrate recognition"
FT /evidence="ECO:0000250"
FT MOD_RES 51
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9HC21"
SQ SEQUENCE 320 AA; 35598 MW; 0339B2642E11B6ED CRC64;
MVGYDPKPDG RNNTKFQVAV AGSVSGLVTR ALISPFDVIK IRFQLQHERL SRSDPNAKYH
GILQASRQIL QEEGPTAFWK GHIPAQILSI GYGAVQFLSF EMLTELVHRG SVYDAREFSV
HFVCGGLAAC MATLTVHPVD VLRTRFAAQG EPKVYNTLCH AVGTMYRSEG PQVFYKGLAP
TLIAIFPYAG LQFSCYSSLK HLYKWAIPAE GKKNENLQNL LCGSGAGVIS KTLTYPLDLF
KKRLQVGGFE HARAAFGQVR RYKGLMDCAK QVLQKEGALG FFKGLSPSLL KAALSTGFMF
FWYEFFCNVF HCMNRTASQR
