TPD1_ARATH
ID TPD1_ARATH Reviewed; 176 AA.
AC Q6TLJ2;
DT 04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Protein TAPETUM DETERMINANT 1 {ECO:0000303|PubMed:14615601};
DE Flags: Precursor;
GN Name=TPD1 {ECO:0000303|PubMed:14615601};
GN OrderedLocusNames=At4g24972 {ECO:0000312|Araport:AT4G24972};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=14615601; DOI=10.1105/tpc.016618;
RA Yang S.L., Xie L.F., Mao H.Z., Puah C.S., Yang W.C., Jiang L.,
RA Sundaresan V., Ye D.;
RT "Tapetum determinant1 is required for cell specialization in the
RT Arabidopsis anther.";
RL Plant Cell 15:2792-2804(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP FUNCTION.
RX PubMed=16055681; DOI=10.1104/pp.105.063529;
RA Yang S.L., Jiang L., Puah C.S., Xie L.F., Zhang X.Q., Chen L.Q., Yang W.C.,
RA Ye D.;
RT "Overexpression of TAPETUM DETERMINANT1 alters the cell fates in the
RT Arabidopsis carpel and tapetum via genetic interaction with excess
RT microsporocytes1/extra sporogenous cells.";
RL Plant Physiol. 139:186-191(2005).
RN [5]
RP FUNCTION, AND INTERACTION WITH EMS1.
RX PubMed=18250314; DOI=10.1073/pnas.0708795105;
RA Jia G., Liu X., Owen H.A., Zhao D.;
RT "Signaling of cell fate determination by the TPD1 small protein and EMS1
RT receptor kinase.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:2220-2225(2008).
RN [6]
RP DISRUPTION PHENOTYPE.
RX PubMed=23893118; DOI=10.1007/s00299-013-1487-1;
RA Matsuo Y., Arimura S., Tsutsumi N.;
RT "Distribution of cellulosic wall in the anthers of Arabidopsis during
RT microsporogenesis.";
RL Plant Cell Rep. 32:1743-1750(2013).
CC -!- FUNCTION: Involved in cell specification during anther and pollen
CC development. Required for the differentiation, specialization and
CC persistence of tapetal cells in the anthers (PubMed:14615601,
CC PubMed:16055681). May serve as an extracellular ligand for the EMS1
CC receptor kinase to signal cell fate determination during plant sexual
CC reproduction (PubMed:18250314). {ECO:0000269|PubMed:14615601,
CC ECO:0000269|PubMed:16055681, ECO:0000269|PubMed:18250314}.
CC -!- SUBUNIT: Interacts with EMS1. {ECO:0000269|PubMed:18250314}.
CC -!- INTERACTION:
CC Q6TLJ2; Q9LYN8: EMS1; NbExp=4; IntAct=EBI-1640767, EBI-1640748;
CC -!- TISSUE SPECIFICITY: Expressed in leaves, young seedlings, inflorescence
CC meristems, floral meristems, carpel primordia and ovule primordia.
CC {ECO:0000269|PubMed:14615601}.
CC -!- DEVELOPMENTAL STAGE: Expressed in flower buds at development stage 2 in
CC archesporial cells, in primary sporogenous cells and primary parietal
CC cells at stage 3, and in secondary parietal cells at early stage 4. In
CC microsporocytes, expression increases at stage 5 and at late stage 5,
CC expressed predominantly in both tapetum and microsporocytes. Expression
CC in tapetum and microsporocytes is reduced greatly at stage 6 and then
CC declined gradually to be not detectable at stage 10.
CC {ECO:0000269|PubMed:14615601}.
CC -!- DISRUPTION PHENOTYPE: Male-sterile phenotype due to the absence of
CC tapetum. Presence of extra microsporocytes in the developing anthers
CC (PubMed:14615601). No effect on cell wall degradation during
CC microsporocyte formation (PubMed:23893118).
CC {ECO:0000269|PubMed:14615601, ECO:0000269|PubMed:23893118}.
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DR EMBL; AY394846; AAR25553.1; -; mRNA.
DR EMBL; AL049657; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002687; AEE84984.1; -; Genomic_DNA.
DR RefSeq; NP_974612.1; NM_202883.3.
DR AlphaFoldDB; Q6TLJ2; -.
DR DIP; DIP-29700N; -.
DR IntAct; Q6TLJ2; 1.
DR STRING; 3702.AT4G24972.1; -.
DR iPTMnet; Q6TLJ2; -.
DR PaxDb; Q6TLJ2; -.
DR PRIDE; Q6TLJ2; -.
DR EnsemblPlants; AT4G24972.1; AT4G24972.1; AT4G24972.
DR GeneID; 2745725; -.
DR Gramene; AT4G24972.1; AT4G24972.1; AT4G24972.
DR KEGG; ath:AT4G24972; -.
DR Araport; AT4G24972; -.
DR TAIR; locus:1006230300; AT4G24972.
DR eggNOG; ENOG502S0K4; Eukaryota.
DR HOGENOM; CLU_102808_0_0_1; -.
DR InParanoid; Q6TLJ2; -.
DR OMA; EIMNICV; -.
DR OrthoDB; 1541320at2759; -.
DR PhylomeDB; Q6TLJ2; -.
DR PRO; PR:Q6TLJ2; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q6TLJ2; baseline and differential.
DR GO; GO:0048653; P:anther development; IDA:TAIR.
DR GO; GO:0001709; P:cell fate determination; IMP:TAIR.
DR InterPro; IPR040361; TPD1.
DR PANTHER; PTHR33184; PTHR33184; 1.
PE 1: Evidence at protein level;
KW Differentiation; Reference proteome; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..176
FT /note="Protein TAPETUM DETERMINANT 1"
FT /evidence="ECO:0000255"
FT /id="PRO_0000432093"
SQ SEQUENCE 176 AA; 19457 MW; EB5CAD7F74EFCBE1 CRC64;
MNRRRLLVSA TLLSYLLYGM ALVSVEASGG EKLRDNLDLT KTTTSSPSIS HRKMLLLSPG
TGKTERSVEP ERIGEKCKST DIVVNQAVTE PMPNGIPGYM VEITNQCMSG CIISRIHINC
GWFSSAKLIN PRVFKRIHYD DCLVNNGKPL PFGSTLSFHY ANTFPYHLSV AFVTCA
