ID   BTUCA_HALSA             Reviewed;         369 AA.
AC   Q9HQ19;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Cobalamin import system permease protein BtuC;
GN   Name=btuC; Synonyms=hemU; OrderedLocusNames=VNG_1370G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN   [2]
RP   FUNCTION IN CORRINOID UTILIZATION.
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=16109931; DOI=10.1128/jb.187.17.5901-5909.2005;
RA   Woodson J.D., Reynolds A.A., Escalante-Semerena J.C.;
RT   "ABC transporter for corrinoids in Halobacterium sp. strain NRC-1.";
RL   J. Bacteriol. 187:5901-5909(2005).
CC   -!- FUNCTION: Required for corrinoid utilization. Probably part of the ABC
CC       transporter complex BtuCDF involved in cobalamin (vitamin B12) import.
CC       Probably involved in the translocation of the substrate across the
CC       membrane. {ECO:0000269|PubMed:16109931}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (BtuD),
CC       two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. FecCD subfamily. {ECO:0000305}.
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DR   EMBL; AE004437; AAG19698.1; -; Genomic_DNA.
DR   PIR; F84291; F84291.
DR   RefSeq; WP_010902994.1; NC_002607.1.
DR   AlphaFoldDB; Q9HQ19; -.
DR   SMR; Q9HQ19; -.
DR   STRING; 64091.VNG_1370G; -.
DR   TCDB; 3.A.1.14.9; the atp-binding cassette (abc) superfamily.
DR   PaxDb; Q9HQ19; -.
DR   EnsemblBacteria; AAG19698; AAG19698; VNG_1370G.
DR   GeneID; 5953598; -.
DR   GeneID; 62886839; -.
DR   KEGG; hal:VNG_1370G; -.
DR   PATRIC; fig|64091.14.peg.1046; -.
DR   HOGENOM; CLU_013016_0_1_2; -.
DR   InParanoid; Q9HQ19; -.
DR   OMA; MQGVFGN; -.
DR   OrthoDB; 36067at2157; -.
DR   PhylomeDB; Q9HQ19; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   Gene3D; 1.10.3470.10; -; 1.
DR   InterPro; IPR037294; ABC_BtuC-like.
DR   InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR   PANTHER; PTHR30472; PTHR30472; 1.
DR   Pfam; PF01032; FecCD; 1.
DR   SUPFAM; SSF81345; SSF81345; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..369
FT                   /note="Cobalamin import system permease protein BtuC"
FT                   /id="PRO_0000408967"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   369 AA;  37452 MW;  8704C7D1145A9191 CRC64;
     MREASARAVA WSAAAGVLLV AVLLVSATIG PEPITLRTVA MAALTELAVP VGASVTMHTH
     AVPVVSGGLP WPALTIAYAA PLQFGVPETA QVIVGTIRLP RIVLGATVGA SLAISGAVLQ
     GFFRNPMADP SIVGVSSGAA VGAVAAITLP SVVVIGVQPA AFAGALIAAF TVYAIATKNG
     HTPTATLLLS GVAVQTLLGA VTSFLVVNSG REIRPAMYWL MGTLHGSRWH DVEAALPVVV
     VGSAVLLAYA REMNVLLAGE EDAHTLGVDV DRTKRLLLAV ASVVTAAAVS FAGAIGFVGL
     IVPHAVRLVV GPDHRVLLPV SALTGGAFLV AADTVARATA TEPPVGIITA LIGAPFFLYL
     LRDREVRAL