TPD55_HUMAN
ID TPD55_HUMAN Reviewed; 140 AA.
AC Q96J77; Q5TCR3; Q5TCR4; Q5TCR5; Q8N4P5; Q8WWF7; Q96M09;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Tumor protein D55;
DE Short=hD55;
DE AltName: Full=Testis development protein NYD-SP25;
DE AltName: Full=Tumor protein D52-like 3;
GN Name=TPD52L3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH TPD52L2, TISSUE
RP SPECIFICITY, AND VARIANT LEU-118.
RC TISSUE=Testis;
RX PubMed=16631610; DOI=10.1016/j.bbrc.2006.03.208;
RA Cao Q., Chen J., Zhu L., Liu Y., Zhou Z., Sha J., Wang S., Li J.;
RT "A testis-specific and testis developmentally regulated tumor protein D52
RT (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins.";
RL Biochem. Biophys. Res. Commun. 344:798-806(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT LEU-118.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND VARIANT
RP LEU-118.
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Interacts with TPD52L2. {ECO:0000269|PubMed:16631610}.
CC -!- INTERACTION:
CC Q96J77; Q6RW13: AGTRAP; NbExp=3; IntAct=EBI-932162, EBI-741181;
CC Q96J77; Q96DZ9: CMTM5; NbExp=3; IntAct=EBI-932162, EBI-2548702;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96J77-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96J77-2; Sequence=VSP_027114;
CC Name=3;
CC IsoId=Q96J77-3; Sequence=VSP_027113;
CC -!- TISSUE SPECIFICITY: Specifically expressed in testis. Expressed at 5.6-
CC fold higher levels in adult testis than in fetal testis.
CC {ECO:0000269|PubMed:16631610}.
CC -!- SIMILARITY: Belongs to the TPD52 family. {ECO:0000305}.
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DR EMBL; AY032877; AAK66820.1; -; mRNA.
DR EMBL; AK057479; BAB71505.1; -; mRNA.
DR EMBL; AL133480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC017589; AAH17589.1; -; mRNA.
DR EMBL; BC033792; AAH33792.1; -; mRNA.
DR EMBL; BC042113; AAH42113.1; -; mRNA.
DR CCDS; CCDS34984.1; -. [Q96J77-2]
DR CCDS; CCDS34985.1; -. [Q96J77-3]
DR CCDS; CCDS34986.1; -. [Q96J77-1]
DR RefSeq; NP_001001874.1; NM_001001874.2. [Q96J77-2]
DR RefSeq; NP_001001875.1; NM_001001875.3. [Q96J77-3]
DR RefSeq; NP_277051.3; NM_033516.5. [Q96J77-1]
DR RefSeq; XP_016870769.1; XM_017015280.1. [Q96J77-3]
DR AlphaFoldDB; Q96J77; -.
DR SMR; Q96J77; -.
DR BioGRID; 124633; 16.
DR IntAct; Q96J77; 11.
DR STRING; 9606.ENSP00000341677; -.
DR iPTMnet; Q96J77; -.
DR PhosphoSitePlus; Q96J77; -.
DR BioMuta; TPD52L3; -.
DR DMDM; 313104031; -.
DR jPOST; Q96J77; -.
DR MassIVE; Q96J77; -.
DR PaxDb; Q96J77; -.
DR PeptideAtlas; Q96J77; -.
DR PRIDE; Q96J77; -.
DR ProteomicsDB; 76893; -. [Q96J77-1]
DR ProteomicsDB; 76894; -. [Q96J77-2]
DR ProteomicsDB; 76895; -. [Q96J77-3]
DR Antibodypedia; 9681; 292 antibodies from 24 providers.
DR DNASU; 89882; -.
DR Ensembl; ENST00000314556.4; ENSP00000318665.3; ENSG00000170777.11. [Q96J77-2]
DR Ensembl; ENST00000344545.6; ENSP00000341677.5; ENSG00000170777.11. [Q96J77-1]
DR Ensembl; ENST00000381428.1; ENSP00000370836.1; ENSG00000170777.11. [Q96J77-3]
DR GeneID; 89882; -.
DR KEGG; hsa:89882; -.
DR MANE-Select; ENST00000314556.4; ENSP00000318665.3; NM_001001874.3; NP_001001874.2. [Q96J77-2]
DR UCSC; uc003zjv.4; human. [Q96J77-1]
DR CTD; 89882; -.
DR DisGeNET; 89882; -.
DR GeneCards; TPD52L3; -.
DR HGNC; HGNC:23382; TPD52L3.
DR HPA; ENSG00000170777; Tissue enriched (testis).
DR MIM; 617567; gene.
DR neXtProt; NX_Q96J77; -.
DR OpenTargets; ENSG00000170777; -.
DR PharmGKB; PA142670712; -.
DR VEuPathDB; HostDB:ENSG00000170777; -.
DR eggNOG; KOG4010; Eukaryota.
DR GeneTree; ENSGT00940000163110; -.
DR HOGENOM; CLU_080743_1_1_1; -.
DR InParanoid; Q96J77; -.
DR OMA; EGIFNKH; -.
DR OrthoDB; 1225782at2759; -.
DR PhylomeDB; Q96J77; -.
DR TreeFam; TF317562; -.
DR PathwayCommons; Q96J77; -.
DR SignaLink; Q96J77; -.
DR BioGRID-ORCS; 89882; 8 hits in 1067 CRISPR screens.
DR GenomeRNAi; 89882; -.
DR Pharos; Q96J77; Tdark.
DR PRO; PR:Q96J77; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q96J77; protein.
DR Bgee; ENSG00000170777; Expressed in sperm and 45 other tissues.
DR Genevisible; Q96J77; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR InterPro; IPR007327; TPD52.
DR PANTHER; PTHR19307; PTHR19307; 1.
DR Pfam; PF04201; TPD52; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..140
FT /note="Tumor protein D55"
FT /id="PRO_0000295856"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 28..57
FT /evidence="ECO:0000255"
FT VAR_SEQ 124..140
FT /note="LMGTIKSKVSGGKRAWP -> NPKGEGSRI (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027113"
FT VAR_SEQ 125..140
FT /note="MGTIKSKVSGGKRAWP -> IFNKYTLNQGRN (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027114"
FT VARIANT 118
FT /note="F -> L (in dbSNP:rs3847262)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:16631610"
FT /id="VAR_033372"
FT CONFLICT 109
FT /note="L -> P (in Ref. 2; BAB71505)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 140 AA; 15503 MW; 759F26E983B1EFAD CRC64;
MPHARTETSV GTYESHSTSE LEDLTEPEQR ELKTKLTKLE AEIVTLRHVL AAKERRCGEL
KRKLGLTALV GLRQNLSKSW LDVQVSNTYV KQKTSAALST MGTLICRKLG GVKKSATFRS
FEGLMGTIKS KVSGGKRAWP
