ID   TPD_RANTE               Reviewed;          13 AA.
AC   P56919;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Temporin-1Td {ECO:0000250|UniProtKB:P56917};
DE            Short=TD {ECO:0000250|UniProtKB:P56917};
DE   AltName: Full=Temporin-D {ECO:0000303|PubMed:9022710};
OS   Rana temporaria (European common frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana; Rana.
OX   NCBI_TaxID=8407;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT LEU-13, SYNTHESIS, AND SUBCELLULAR LOCATION.
RC   TISSUE=Skin secretion;
RX   PubMed=9022710; DOI=10.1111/j.1432-1033.1996.0788r.x;
RA   Simmaco M., Mignogna G., Canofeni S., Miele R., Mangoni M.L., Barra D.;
RT   "Temporins, antimicrobial peptides from the European red frog Rana
RT   temporaria.";
RL   Eur. J. Biochem. 242:788-792(1996).
RN   [2]
RP   FUNCTION.
RX   PubMed=10691983; DOI=10.1046/j.1432-1327.2000.01143.x;
RA   Mangoni M.L., Rinaldi A.C., Di Giulio A., Mignogna G., Bozzi A., Barra D.,
RA   Simmaco M.;
RT   "Structure-function relationships of temporins, small antimicrobial
RT   peptides from amphibian skin.";
RL   Eur. J. Biochem. 267:1447-1454(2000).
CC   -!- FUNCTION: Has no antibacterial activity (PubMed:10691983). Has
CC       hemolytic activity (PubMed:10691983). {ECO:0000269|PubMed:10691983}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9022710}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000305|PubMed:9022710}.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Temporin subfamily. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=00858";
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial; Cytolysis;
KW   Direct protein sequencing; Hemolysis; Immunity; Innate immunity; Secreted.
FT   PEPTIDE         1..13
FT                   /note="Temporin-1Td"
FT                   /evidence="ECO:0000269|PubMed:9022710"
FT                   /id="PRO_0000043581"
FT   MOD_RES         13
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:9022710"
SQ   SEQUENCE   13 AA;  1379 MW;  3EF35DFA655B2448 CRC64;
     LLPIVGNLLN SLL